FB2021_02, released April 13, 2021

Allele: Dmel\GABA-B-R3attP

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General Information
Symbol
Dmel\GABA-B-R3attP
Species
D. melanogaster
Name
FlyBase ID
FBal0355404
Feature type
allele
Associated gene
Dmel\GABA-B-R3
Associated Insertion(s)
TI{TI}GABA-B-R3attP
Carried in Construct
Key Links
Genomic Maps
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Rao and Deng, 2019.10.23)
gene targeting by homologous recombination
(Rao and Deng, 2019.10.23)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
complex_substitution
2L:756,572..760,894
Reported_genomic_loc:

2L_r6:756572..760894

Comment:

A attP-Disc\RFP3xP3.cUa-loxP cassette replaces the deleted genomic sequence.

Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Cytology
      Nature of the lesion
      Statement
      Reference

      An attP-Disc\RFP3xP3.cUa-loxP cassette replaces part of GABA-B-R3.

      (Rao and Deng, 2019.10.23)
      Insertion components
      TI{TI}GABA-B-R3attP
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      GABA-B-R3attP adults exhibit a significant decrease in both day and night time sleep duration when compared to controls.

      (Deng et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      GABA-B-R3-attP
      (Rao and Deng, 2019.10.23)
      GABA-B-R3attP
      ISODRZ3-CG3022-1
      (Rao and Deng, 2019.10.23)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)