FB2021_01, released Feb 18, 2021

Allele: Dmel\taudsRNA.UAS

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General Information
Symbol
Dmel\taudsRNA.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0356103
Feature type
allele
Associated gene
Dmel\tau
Associated Insertion(s)
Carried in Construct
P{UAS-tau.RNAi}
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
in vitro construct - regulatory fusion
(Papanikolopoulou et al., 2019)
in vitro construct - RNAi
(Papanikolopoulou et al., 2019)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Carried in construct
      P{UAS-tau.RNAi}
      Cytology
      Nature of the lesion
      Statement
      Reference

      UASt regulatory sequences drive expression of RNAi against tau (target region was a 632bp from all tau isoforms).

      (Papanikolopoulou et al., 2019)
      Allele components
      Product class / Tool use(s)
      Regulatory region(s)
      UASt
      Encoded product / tool
      tau
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of taudsRNA.UAS under the control of Scer\GAL4elav-C155, Scer\GAL4NP0863, Scer\GAL4GMR13F02, Scer\GAL4Mef2.247, Scer\GAL4c305a or Scer\GAL4c739, in combination with a Gal80[ts] transgene to restrict expression to the adult stage, significantly increases aversive olfactory 24 h memory following spaced training, compared to controls; in the case of Scer\GAL4GMR13F02 and Scer\GAL4c739, there is no effect on 3 min memory, compared to controls; in the case of Scer\GAL4c739, there is no effect on the odor preference switch when conditioned odors are reversed (reversal learning), compared to controls; expression under the control of Scer\GAL4elav-C155, Scer\GAL4NP0863, Scer\GAL4GMR13F02, Scer\GAL4Mef2.247, Scer\GAL4c305a, but not Scer\GAL4c739, in combination with a Gal80[ts] transgene to restrict expression to the adult stage, results in a significant failure to habituate to electric shocks, compared to controls.

      (Papanikolopoulou et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      taudsRNA.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)