An insertion-deletion (indel) mutation consisting of a deletion of thirteen nucleotides (from base pair 104 to 118) combined with an insertion of three nucleotides, resulting in a frameshift at the amino acid position 36 and a premature stop codon after amino acid 107. If the resulting mRNA would produce only a truncated protein lacking the full methyltransferase domain.
Three lesions, two deletions and an insertion, were detected in Mettl5[fs]. The combination of these lesions results in a frameshift after codon 35 (Ile) followed by 73 codons translated out of frame and a premature stop.
Three lesions, two deletions and an insertion, were detected in Mettl5[fs]. The combination of these lesions results in a frameshift after codon 35 (Ile) followed by 73 codons translated out of frame and a premature stop.
CTG
Three lesions, two deletions and an insertion, were detected in Mettl5[fs]. The combination of these lesions results in a frameshift after codon 35 (Ile) followed by 73 codons translated out of frame and a premature stop.
Mettl5fs/Mettl5fs or Mettl5fs/Df(3L)ED4786 adults are severely disoriented as they changed their walking directions more often than controls.
