FlyBase Allele Report: Hsap\CFTR[WT.UAS.Tag:HA]

FB2025_01 , released February 20, 2025

FB2025_01 , released February 20, 2025

Allele: Hsap\CFTR^{WT.UAS.Tag:HA}

General Information

Symbol

Hsap\CFTR^{WT.UAS.Tag:HA}

Species

H. sapiens

Name

FlyBase ID

FBal0362143

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

P{UAS-hCFTR.WT.HA}

Key Links

Transgenic product class

(Kim et al., 2020)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Kim et al., 2020)

Mutagen

in vitro construct

(Kim et al., 2020)

Progenitor genotype

Carried in construct

P{UAS-hCFTR.WT.HA}

Cytology

Description

UAS and a core promoter regulates expression of wild type Hsap\CFTR tagged with Tag:HA.

(Kim et al., 2020)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Tagged with

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates cystic fibrosis

modeled by Cftr^NIG.5789R

(Kim et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Hsap\CFTR^{WT.UAS.Tag:HA}, Scer\GAL4^Act5C.PP is a suppressor of increased cell size | adult stage phenotype of Cftr^NIG.5789R, Scer\GAL4^Act5C.PP

(Kim et al., 2020)

Hsap\CFTR^{WT.UAS.Tag:HA}, Scer\GAL4^Myo31DF.PU is a suppressor of abnormal immune response | adult stage phenotype of Cftr^NIG.5789R, Scer\GAL4^Myo31DF.PU

(Kim et al., 2020)

Hsap\CFTR^{WT.UAS.Tag:HA}, Scer\GAL4^Myo31DF.PU is a suppressor of short lived | conditional phenotype of Cftr^NIG.5789R, Scer\GAL4^Myo31DF.PU

(Kim et al., 2020)

Hsap\CFTR^{WT.UAS.Tag:HA}, Scer\GAL4^Myo31DF.PU is a suppressor | partially of increased occurrence of cell division | adult stage phenotype of Cftr^NIG.5789R, Scer\GAL4^Myo31DF.PU

(Kim et al., 2020)

Phenotype Manifest In

Suppressor of

Statement

Reference

Hsap\CFTR^{WT.UAS.Tag:HA}, Scer\GAL4^Act5C.PP is a suppressor of enterocyte of anterior adult midgut epithelium | somatic clone | adult stage phenotype of Cftr^NIG.5789R, Scer\GAL4^Act5C.PP

(Kim et al., 2020)

Hsap\CFTR^{WT.UAS.Tag:HA}, Scer\GAL4^Myo31DF.PU is a suppressor of adult peritrophic membrane phenotype of Cftr^NIG.5789R, Scer\GAL4^Myo31DF.PU

(Kim et al., 2020)

Hsap\CFTR^{WT.UAS.Tag:HA}, Scer\GAL4^Myo31DF.PU is a suppressor | partially of adult midgut epithelium phenotype of Cftr^NIG.5789R, Scer\GAL4^Myo31DF.PU

(Kim et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Hsap\CFTR^{WT.UAS.Tag:HA}

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections