FlyBase Allele Report: Dmel\emei[1]

General Information

Symbol

Dmel\emei¹

Species

D. melanogaster

Name

FlyBase ID

FBal0362620

Feature type

allele

Associated gene

Dmel\emei

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Ma et al., 2020)

Progenitor genotype

Cytology

Description

Amino acid replacement: Q109term.

(Ma et al., 2020)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:11,110,351..11,110,351 [+]

Nucleotide change:

C11110351T

Amino acid change:

Q109term | emei-PA

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Ma et al., 2020)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates cancer

modeled by Ras85D^V12.UAS

(Ma et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

eye disc

(Ma et al., 2020)

Detailed Description

Statement

Reference

emei¹ homozygous mutant eye discs display abnormal morphology (e.g. altered shape and tissue folding).

(Ma et al., 2020)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has some die during larval stage | somatic clone phenotype, suppressible by bsk^DN.UAS.cUa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has increased occurrence of cell division | somatic clone | larval stage phenotype, suppressible by bsk^DN.UAS.cUa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has increased occurrence of cell division | somatic clone | larval stage phenotype, suppressible by Stim^RNAi.cEa.UAS, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has neoplasia | somatic clone | larval stage phenotype, suppressible | partially by POSH^GD11467, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has neoplasia | somatic clone | larval stage phenotype, suppressible | partially by SERCA^UAS.cFa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has some die during larval stage | somatic clone phenotype, suppressible by emei^UAS.cMa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has some die during larval stage | somatic clone phenotype, suppressible by wts^UAS.cYa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has neoplasia | somatic clone | larval stage phenotype, suppressible by wts^UAS.cYa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Enhancer of

Statement

Reference

emei¹/emei¹ is an enhancer of neoplasia | larval stage | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

emei¹/emei¹ is an enhancer of increased occurrence of cell division | larval stage | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

NOT Enhancer of

Statement

Reference

emei^UAS.cMa, emei¹, emei¹, Scer\GAL4^Act5C.PI is a non-enhancer of increased occurrence of cell division | larval stage | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

NOT Suppressor of

Statement

Reference

emei^UAS.cMa, emei¹, emei¹, Scer\GAL4^Act5C.PI is a non-suppressor of increased occurrence of cell division | somatic clone | larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Other

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has neoplasia | somatic clone | larval stage phenotype

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has some die during larval stage | somatic clone phenotype

(Ma et al., 2020)

Phenotype Manifest In

Suppressed by

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has eye disc | somatic clone phenotype, suppressible by wts^UAS.cYa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has eye disc | somatic clone phenotype, suppressible by bsk^DN.UAS.cUa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has eye disc | somatic clone phenotype, suppressible by Stim^RNAi.cEa.UAS, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has eye disc | somatic clone phenotype, suppressible | partially by POSH^GD11467, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has eye disc | somatic clone phenotype, suppressible | partially by SERCA^UAS.cFa, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Enhancer of

Statement

Reference

emei¹/emei¹ is an enhancer of eye disc | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

NOT Enhancer of

Statement

Reference

emei^UAS.cMa, emei¹, emei¹, Scer\GAL4^Act5C.PI is a non-enhancer of eye disc | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

NOT Suppressor of

Statement

Reference

emei^UAS.cMa, emei¹, emei¹, Scer\GAL4^Act5C.PI is a non-suppressor of eye disc | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PI

(Ma et al., 2020)

Other

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has wing disc phenotype

(Ma et al., 2020)

Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, emei¹ has larval ventral nerve cord | larval stage phenotype

(Ma et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Ras85D^V12.UAS under the control of Scer\GAL4^Act5C.PI and emei¹ homozygosity synergize to induce tumor formation in wing disc clones.

Tumors derived from clones that both express Ras85D^V12.UAS under the control of Scer\GAL4^Act5C.PI and are emei¹ homozygous display invasive behavior into the ventral nerve cord.

(Ma et al., 2020)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

emei³

(Ma et al., 2020)

emei²

(Ma et al., 2020)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

emei¹

(Ma et al., 2020)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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