FlyBase Allele Report: Dmel\Haspin[128]

General Information

Symbol

Dmel\Haspin¹²⁸

Species

D. melanogaster

Name

FlyBase ID

FBal0363215

Feature type

allele

Associated gene

Dmel\Haspin

Associated Insertion(s)

P{?'Mae-UAS.6.11}Haspin¹²⁸

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Fresán et al., 2020)

Progenitor genotype

P{Mae-UAS.6.11}Haspin⁸⁶

(Fresán et al., 2020)

Associated Insertion(s)

P{?'Mae-UAS.6.11}Haspin¹²⁸

Cytology

Description

Imprecise excision of the P{Mae-UAS.6.11}Haspin⁸⁶ insertion, resulting in deletion of part of the inserted P{Mae-UAS.6.11} element and of the first and second exons and part of the second exon of Haspin.

(Fresán et al., 2020)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:4,014,146..4,019,810 [+]

Comment:

(Espinas, 2020.12.10)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle | larval stage

(Fresán et al., 2020)

female semi-fertile

(Fresán et al., 2020)

fertile

(Wang et al., 2021)

male semi-fertile

(Fresán et al., 2020)

short lived

(Fresán et al., 2020)

suppressor of variegation | dominant

(Fresán et al., 2020)

viable

(Wang et al., 2021, Fresán et al., 2020)

Phenotype Manifest In

embryonic/larval salivary gland | larval stage

(Fresán et al., 2020)

larval brain | larval stage

(Fresán et al., 2020)

nucleus | larval stage

(Fresán et al., 2020)

Detailed Description

Statement

Reference

In Haspin¹²⁸ larval brains, the inter-kinetochore distance on chromosome spreads is further apart compared to controls.

Haspin¹²⁸ larval salivary glands exhibit a decrease in the size of nuclei.

(Fresán et al., 2020)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Haspin¹²⁸, Pc³ has homeotic phenotype, enhanceable by vtd^ex3

(Fresán et al., 2020)

Haspin¹²⁸, Pc³ has homeotic phenotype, enhanceable by pds5^e6

(Fresán et al., 2020)

Enhancer of

Statement

Reference

Haspin¹²⁸/Haspin¹²⁸ is an enhancer of homeotic phenotype of Pc¹⁵

(Fresán et al., 2020)

Haspin¹²⁸/Haspin¹²⁸ is an enhancer of homeotic phenotype of Pc¹

(Fresán et al., 2020)

Haspin¹²⁸/Haspin¹²⁸ is an enhancer of homeotic phenotype of Pc³

(Fresán et al., 2020)

Other

Statement

Reference

Haspin¹²⁸, Pc¹⁵ has homeotic phenotype

(Fresán et al., 2020)

Phenotype Manifest In

Suppressor of

Statement

Reference

Haspin¹²⁸ is a suppressor | partially of wing phenotype of sd^Fab-X

(Fresán et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Pc¹⁵/+ Haspin¹²⁸/+ adults exhibit an appearance of sex combs on the third pairs of legs of male flies and a defective wing development indicative of a wing to haltere transformation.

(Fresán et al., 2020)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Haspin¹²⁸ is rescued by Haspin^UAS.Tag:HA/Scer\GAL4^69B

(Fresán et al., 2020)

Not rescued by

Haspin¹²⁸ is not rescued by Haspin^{H420A.UAS.Tag:HA}/Scer\GAL4^69B

(Fresán et al., 2020)

Haspin¹²⁸ is not rescued by Haspin^{K282M.UAS.Tag:HA}/Scer\GAL4^69B

(Fresán et al., 2020)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Haspin¹²⁸

(Wang et al., 2021, Espinas, 2020.12.10)

haspin¹²⁸

(Fresán et al., 2020)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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