FB2025_02 , released April 17, 2025
Allele: Dmel\arrm7.UAS.Tag:HA
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General Information
Symbol
Dmel\arrm7.UAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0365348
Feature type
allele
Associated gene
Dmel\arr
Associated Insertion(s)
Carried in Construct
P{UAS-arr.m7.HA}
Key Links
Transgenic product class
dominant_negative_variant
(Han et al., 2020)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Han et al., 2020)
Mutagen
in vitro construct
(Han et al., 2020)
Progenitor genotype
Carried in construct
P{UAS-arr.m7.HA}
Cytology
Description

UAS regulatory sequences drive expression of arr that has been mutated to carry the same lesion as in arrm7; a nonsense mutation in the seventh exon of that is predicted to result in the truncation of 191 amino acid residues from the encoded protein. The coding sequence is tagged with Tag:HA. The protein produced acts as a dominant-negative.

(Han et al., 2020)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
arr
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of arrm7.UAS.Tag:HA under the control of Scer\GAL4en.PU or Scer\GAL4nub.PU leads to notched wings when compared to controls.

      Expression of arrm7.UAS.Tag:HA under the control of Scer\GAL4en.PU leads to increased cell death in wing discs when compared to controls.

      (Han et al., 2020)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      arrm7.UAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (1)