FlyBase Allele Report: Dmel\Mnat9[AcDel.UAS]

General Information

Symbol

Dmel\Mnat9^AcDel.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0366577

Feature type

allele

Associated gene

Dmel\Mnat9

Associated Insertion(s)

Carried in Construct

P{UAS-Mnat9.AcDel}

Also Known As

UAS-Mnat9^AcDel

Key Links

Transgenic product class

inframe_deletion

(Mok and Choi, 2021)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Mok and Choi, 2021)

Mutagen

in vitro construct

(Mok and Choi, 2021)

Progenitor genotype

Carried in construct

P{UAS-Mnat9.AcDel}

Cytology

Description

UAS regulatory sequences drive expression of mutant Mnat9 which has a deletion of six amino acids in the acetyl-CoA binding site.

(Mok and Choi, 2021)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Mnat9

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^2xAPP.SP.UAS

(Deshpande et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | adult stage, with Scer\GAL4^pnr-MD237

(Mok and Choi, 2021)

Phenotype Manifest In

adult thorax, with Scer\GAL4^pnr-MD237

(Mok and Choi, 2021)

Detailed Description

Statement

Reference

The expression of Mnat9^AcDel.UAS under the control of Scer\GAL4^pnr-MD237 leads to a thorax cleft phenotype.

(Mok and Choi, 2021)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Mnat9^AcDel.UAS, Scer\GAL4^GMR.long is a suppressor | partially of visible | adult stage phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Mnat9^AcDel.UAS, Scer\GAL4^GMR.long is a suppressor | partially of decreased size | adult stage phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Mnat9^AcDel.UAS, Scer\GAL4^GMR.long is a suppressor | partially of abnormal neuroanatomy | larval stage phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Other

Statement

Reference

Mnat9^AcDel.UAS, Scer\GAL4^pnr-MD237, hpo^KK101704 has visible | adult stage phenotype

(Mok and Choi, 2022)

Mnat9^AcDel.UAS, Scer\GAL4^pnr-MD237, hpo^KK101704 has melanotic mass phenotype | adult stage phenotype

(Mok and Choi, 2022)

Phenotype Manifest In

Suppressor of

Statement

Reference

Mnat9^AcDel.UAS, Scer\GAL4^GMR.long is a suppressor | partially of eye phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Mnat9^AcDel.UAS, Scer\GAL4^GMR.long is a suppressor | partially of eye disc | larval stage phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Other

Statement

Reference

Mnat9^AcDel.UAS, Scer\GAL4^pnr-MD237, hpo^KK101704 has adult external abdomen phenotype

(Mok and Choi, 2022)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Mnat9^AcDel.UAS

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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