FlyBase Allele Report: Dmel\NUCB1[Nesfatin1.UAS]

General Information

Symbol

Dmel\NUCB1^{Nesfatin1.UAS}

Species

D. melanogaster

Name

FlyBase ID

FBal0367125

Feature type

allele

Associated gene

Dmel\NUCB1

Associated Insertion(s)

Carried in Construct

P{UAS-NUCB1.Nesfatin1}

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Yeom et al., 2021)

Progenitor genotype

Carried in construct

P{UAS-NUCB1.Nesfatin1}

Cytology

Description

UAS regulatory sequences drive expression of 'Nesfatin1', a processed form of NUCB1.

(Yeom et al., 2021)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

NUCB1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates tauopathy

modeled by Hsap\MAPT^UAS.wt

(Yang et al., 2024)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of larval stage, with Scer\GAL4^Eq

(Yang et al., 2024)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

NUCB1^{Nesfatin1.UAS}, Scer\GAL4^Eq has increased mortality during development phenotype, suppressible | partially by Hsap\MAPT^UAS.wt, Scer\GAL4^Eq

(Yang et al., 2024)

Enhancer of

Statement

Reference

NUCB1^{Nesfatin1.UAS}, Scer\GAL4^Eq is an enhancer of visible | adult stage phenotype of Hsap\MAPT^UAS.wt, Scer\GAL4^Eq

(Yang et al., 2024)

Suppressor of

Statement

Reference

NUCB1^{Nesfatin1.UAS}, Scer\GAL4^GMR.PU is a suppressor | partially of visible | adult stage phenotype of Hsap\MAPT^UAS.wt, Scer\GAL4^GMR.PU

(Yang et al., 2024)

NUCB1^{Nesfatin1.UAS}, Scer\GAL4^GMR.PU is a suppressor | partially of decreased size | adult stage phenotype of Hsap\MAPT^UAS.wt, Scer\GAL4^GMR.PU

(Yang et al., 2024)

NUCB1^{Nesfatin1.UAS}, Scer\GAL4^elav.PU is a suppressor of decreased rate of larval locomotory behavior phenotype of Hsap\MAPT^UAS.wt, Scer\GAL4^elav.PU

(Yang et al., 2024)

NUCB1^{Nesfatin1.UAS}, Scer\GAL4^elav.PU is a suppressor of short lived phenotype of Hsap\MAPT^UAS.wt, Scer\GAL4^elav.PU

(Yang et al., 2024)

Phenotype Manifest In

Enhancer of

Statement

Reference

NUCB1^{Nesfatin1.UAS}, Scer\GAL4^Eq is an enhancer of scutum phenotype of Hsap\MAPT^UAS.wt, Scer\GAL4^Eq

(Yang et al., 2024)

Suppressor of

Statement

Reference

NUCB1^{Nesfatin1.UAS}, Scer\GAL4^GMR.PU is a suppressor | partially of eye phenotype of Hsap\MAPT^UAS.wt, Scer\GAL4^GMR.PU

(Yang et al., 2024)

NUCB1^{Nesfatin1.UAS}, Scer\GAL4^elav.PU is a suppressor of NMJ bouton | larval stage | decreased number phenotype of Hsap\MAPT^UAS.wt, Scer\GAL4^elav.PU

(Yang et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

NUCB1^{Nesfatin1.UAS}

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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