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General Information
Symbol
Dmel\PolQZIII-2003
Species
D. melanogaster
Name
FlyBase ID
FBal0367616
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C12707491T

Amino acid change:

Q1513term | DNApol-theta-PA

Reported amino acid change:

Q1513term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: Q1513term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

mus308ZIII-2003/Df(3R)Exel6166 larvae are unable to survive exposure to 0.005% mechlorethamine (nitrogen mustard).

mus308ZIII-2003/Df(3R)Exel6166 animals are able to survive exposures of as high as 4000rads of ionising radiation.

Studies of excision and repair events of P{hswa} in mus308ZIII-2003/mus308Sz29 males indicate that they are specifically defective in end-joining repair of DNA double-strand breaks. There is a substantial increase in the percentage of deletion-associated repair events isolated from mus308ZIII-2003 mutant males relative to those isolated from wild-type males.

Mutant larvae are sensitive to nitrogen mustard (compared to control larvae). Mutant larvae are not sensitive to methyl methanesulfonate.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

There is a decrease in the percentage of end-joining repair products in studies of excision and repair events of P{hswa} in spn-A3 mus308D2/spn-A3 mus308ZIII-2003 and spn-A093A mus308D5/spn-A3 mus308ZIII-2003 double mutant males compared to the percentage seen in spn-A single mutants. The double mutants show a substantial increase in the percentage of deletion-associated repair events isolated compared to controls, as occurs in mus308 single mutants. These males show increased sterility.

spn-A3 mus308D2/spn-A3 mus308ZIII-2003 double mutant males in which excision of P{hswa} is occurring show morphological defects such as abdominal cuticle mispatterning.

There is a further decrease in the percentage of end-joining repair products in studies of excision and repair events of P{hswa} in Lig4169 ; mus308ZIII-2003/Df(3R)kar3l double mutant males compared to the percentage seen in mus308ZIII-2003/Df(3R)kar3l single mutant males. 100% of the end-joining repair products are associated with large deletions in the double mutant males.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (8)
Reported As
Symbol Synonym
DNApol-θ2003
DNApol-θZIII-2003
PolQ2003
PolQZIII-2003
mus3082003
mus308ZIII-2003
Name Synonyms
Secondary FlyBase IDs
  • FBal0154865
  • FBal0258516
References (4)