FB2025_01 , released February 20, 2025
Allele: Dmel\iPLA2-VIASA.UAS.PB.Tag:HA
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General Information
Symbol
Dmel\iPLA2-VIASA.UAS.PB.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0369565
Feature type
allele
Associated gene
Dmel\iPLA2-VIA
Associated Insertion(s)
Carried in Construct
PBac{UAS-iPLA2-VIA.PB.SA.HA}
Key Links
Transgenic product class
missense_variant
(Banerjee et al., 2021)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Banerjee et al., 2021)
Mutagen
in vitro construct
(Banerjee et al., 2021)
Progenitor genotype
Carried in construct
PBac{UAS-iPLA2-VIA.PB.SA.HA}
Cytology
Description

UASt regulatory sequences drive expression of the iPLA2-VIA PB isoform (sequence amplified from the RE23733 cDNA), in which the catalytic Ser residue has been mutated to Ala; this has previously been shown to abrogate catalytic activity. The coding sequence is tagged at the C-terminal end with three copies of Tag:HA.

(Banerjee et al., 2021)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
iPLA2-VIA
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  neurodegenerative disease
      modeled by iPLA2-VIAΔ23
      (Banerjee et al., 2021)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      iPLA2-VIASA.UAS.PB.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (1)