FB2025_01 , released February 20, 2025
Allele: Dmel\EndoB4
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General Information
Symbol
Dmel\EndoB4
Species
D. melanogaster
Name
FlyBase ID
FBal0371651
Feature type
allele
Associated gene
Dmel\EndoB
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Hernandez-Diaz et al., 2022)
Mutagen
P-element activity
(Hernandez-Diaz et al., 2022)
Progenitor genotype
P{EPgy2}EndoBEY00696
(Hernandez-Diaz et al., 2022)
Cytology
Description

Imprecise excision of P{EPgy2}EndoBEY00696.

(Hernandez-Diaz et al., 2022)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease 8
      modeled by Hsap\LRRK2G2019S.UAS.Tag:MYC
      (Hernandez-Diaz et al., 2022)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Unlike controls, EndoB4 larvae fail to show starvation-induced increase in autophagosomes (Atg8-mCherry) and autolysosomes (Lamp-GFP) at NMJ boutons; autophagosomes are also not starvation-induced in motor neurons soma.

      In EndoB4 pupae, eye photoreceptor exhibit decreased autophagosomes (Atg8-mCherry) in their axons, increased presynaptic active zones per lamina cartridge.

      EndoB4 adults exhibit light-induced photoreceptor degeneration, with reduced number of photoreceptors per ommatidia and degenerating rhabdomeres, and reduced number of photoreceptor terminals per cartridge in the lamina. 30 days old individuals show fewer PPM1/2 and PPL1 dopaminergic neurons.

      (Hernandez-Diaz et al., 2022)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      EndoB4 has embryonic/larval neuromuscular junction | larval stage | nutrition conditional phenotype, non-suppressible by Hsap\LRRK2G2019S.UAS.Tag:MYC/Scer\GAL4Toll-6-D42

      (Hernandez-Diaz et al., 2022)

      EndoB4 has NMJ bouton | larval stage | nutrition conditional phenotype, non-suppressible by Hsap\LRRK2G2019S.UAS.Tag:MYC/Scer\GAL4Toll-6-D42

      (Hernandez-Diaz et al., 2022)

      EndoB4 has autophagosome | larval stage | decreased number | nutrition conditional phenotype, non-suppressible by Hsap\LRRK2G2019S.UAS.Tag:MYC/Scer\GAL4Toll-6-D42

      (Hernandez-Diaz et al., 2022)

      EndoB4 has autophagosome | larval stage | decreased number | nutrition conditional phenotype, non-suppressible by EndoA26/EndoAΔ4/EndoAS75D.CyPet

      (Hernandez-Diaz et al., 2022)

      EndoB4 has embryonic/larval neuromuscular junction | larval stage | nutrition conditional phenotype, non-suppressible by EndoA26/EndoAΔ4/EndoAS75D.CyPet

      (Hernandez-Diaz et al., 2022)

      EndoB4 has NMJ bouton | larval stage | nutrition conditional phenotype, non-suppressible by EndoA26/EndoAΔ4/EndoAS75D.CyPet

      (Hernandez-Diaz et al., 2022)

      EndoB4 has autolysosome | larval stage | decreased number | nutrition conditional phenotype, non-suppressible by EndoA26/EndoAΔ4/EndoAS75D.CyPet

      (Hernandez-Diaz et al., 2022)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      EndoB4 is partially rescued by EndoB+tBac

      (Hernandez-Diaz et al., 2022)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      EndoB4
      endoB4
      (Hernandez-Diaz et al., 2022)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)