FlyBase Allele Report: Dmel\Hap40[ko3]

General Information

Symbol

Dmel\Hap40^ko3

Species

D. melanogaster

Name

FlyBase ID

FBal0376306

Feature type

allele

Associated gene

Dmel\Hap40

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Xu et al., 2022)

Mutagen

CRISPR/Cas9

(Xu et al., 2022)

Progenitor genotype

Cytology

Description

Deletion and frameshift in the exon 2 region of Hap40.

(Xu et al., 2022)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:15,704,727..15,704,866 [+]

Comment:

140bp deletion and frameshift in the 2nd exon of Hap40 starting at amino acid 101.

(Xu et al., 2022)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^128Q.FL.UAS

(Xu et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage

(Xu et al., 2022)

short lived

(Xu et al., 2022)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Hap40^ko3 has short lived phenotype, suppressible by Hsap\F8A1^UAS.cXa/Scer\GAL4^da.G32

(Xu et al., 2022)

NOT Enhancer of

Statement

Reference

Hap40^ko3 is a non-enhancer of abnormal neuroanatomy | adult stage phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Xu et al., 2022)

Hap40^ko3 is a non-enhancer of decreased cell number | adult stage phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Xu et al., 2022)

Suppressor of

Statement

Reference

Hap40^ko3 is a suppressor | partially of short lived phenotype of Hsap\HTT^128Q.FL.UAS, Scer\GAL4^nSyb.PS

(Xu et al., 2022)

Hap40^ko3 is a suppressor | partially of abnormal neuroanatomy | adult stage phenotype of Hsap\HTT^128Q.FL.UAS, Scer\GAL4^nSyb.PS

(Xu et al., 2022)

Hap40^ko3 is a suppressor | partially of decreased cell number | adult stage phenotype of Hsap\HTT^128Q.FL.UAS, Scer\GAL4^nSyb.PS

(Xu et al., 2022)

Hap40^ko3 is a suppressor | partially of decreased cell number | adult stage phenotype of Hsap\HTT^{145Q.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Xu et al., 2022)

Hap40^ko3 is a suppressor | partially of abnormal neuroanatomy | adult stage phenotype of Hsap\HTT^{145Q.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Xu et al., 2022)

Hap40^ko3 is a suppressor | partially of visible | adult stage | progressive phenotype of Hsap\HTT^{145Q.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Xu et al., 2022)

NOT Suppressor of

Statement

Reference

Hap40^ko3 is a non-suppressor of abnormal neuroanatomy | adult stage phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Xu et al., 2022)

Hap40^ko3 is a non-suppressor of decreased cell number | adult stage phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Xu et al., 2022)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Hap40^ko3 is a non-enhancer of eye photoreceptor cell | adult stage | decreased number phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Xu et al., 2022)

Suppressor of

Statement

Reference

Hap40^ko3 is a suppressor | partially of eye photoreceptor cell | adult stage | decreased number phenotype of Hsap\HTT^{145Q.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Xu et al., 2022)

Hap40^ko3 is a suppressor | partially of ommatidium | adult stage phenotype of Hsap\HTT^{145Q.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Xu et al., 2022)

Hap40^ko3 is a suppressor | partially of eye phenotype of Hsap\HTT^{145Q.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Xu et al., 2022)

Hap40^ko3 is a suppressor | partially of eye photoreceptor cell | adult stage | decreased number phenotype of Hsap\HTT^128Q.FL.UAS, Scer\GAL4^nSyb.PS

(Xu et al., 2022)

NOT Suppressor of

Statement

Reference

Hap40^ko3 is a non-suppressor of eye photoreceptor cell | adult stage | decreased number phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Xu et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Hap40^ko3 is rescued by Scer\GAL4^da.G32/Hap40^UAS.cXa

(Xu et al., 2022)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hap40^ko3

dhap40^ko3

(Xu et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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