FlyBase Allele Report: Dmel\comm[Δe39]

General Information

Symbol

Dmel\comm^Δe39

Species

D. melanogaster

Name

FlyBase ID

FBal0385620

Feature type

allele

Associated gene

Dmel\comm

Associated Insertion(s)

Carried in Construct

Also Known As

comm^e39

Key Links

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Georgiou and Tear, 2002, Kidd et al., 1999)

Mutagen

Progenitor genotype

Cytology

Description

Deletion of the comm transcription unit.

(Georgiou and Tear, 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Evans et al., 2015, Georgiou and Tear, 2002)

abnormal neuroanatomy | embryonic stage

(van den Brink et al., 2013)

abnormal neuroanatomy | embryonic stage 16

(Coleman et al., 2010)

abnormal neuroanatomy | embryonic stage | recessive

(Daiber et al., 2021)

Phenotype Manifest In

Detailed Description

Statement

Reference

Commissural axons fail to extend across the midline and extend within the longitudinal pathways in mutant embryos.

(van den Brink et al., 2013)

comm^Δe39 homozygous stage 16 embryos completely lack axon commissures.

(Coleman et al., 2010)

comm^E39 mutants exhibit commissural defects but have no salivary gland defects.

(Kolesnikov and Beckendorf, 2005)

Stage 17 comm^Δe39 mutant embryos have reduced numbers of midline glial cells. Those that remain do not reside in the axon free space that is the midline of these embryos, but instead line up along the longitudinal connectives; i.e.- those that survive are in contact with neurons.

(Bergmann et al., 2002)

The commissures fail to form in mutant embryos.

(Georgiou and Tear, 2002)

Axons do not cross the midline in mutant embryos. Three distinct Fas2-expressing longitudinal pathways on each side of the midline are still seen.

(Simpson et al., 2000)

No axons cross the midline in the central nervous system of comm^Δe39 embryos.

(Kidd et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

comm^Δe39 has abnormal neuroanatomy phenotype, suppressible by robo1::robo2^{R2I1+2.UAS.Tag:HA,Tag:SS(wg)}/Scer\GAL4^elav.PLu

(Evans et al., 2015)

comm^Δe39 has abnormal neuroanatomy phenotype, suppressible by robo2^{UAS.Tag:HA,Tag:SS(wg)}/Scer\GAL4^elav.PLu

(Evans et al., 2015)

comm^Δe39 has abnormal neuroanatomy | embryonic stage 16 phenotype, suppressible by kuz^unspecified

(Coleman et al., 2010)

NOT suppressed by

Statement

Reference

comm^Δe39 has abnormal neuroanatomy phenotype, non-suppressible by robo2^{ΔIg1.10xUAS.Tag:HA,Tag:SS(wg)}/Scer\GAL4^elav.PLu

(Evans et al., 2015)

comm^Δe39 has abnormal neuroanatomy phenotype, non-suppressible by robo2^{ΔIg2.10xUAS.Tag:HA,Tag:SS(wg)}/Scer\GAL4^elav.PLu

(Evans et al., 2015)

comm^Δe39 has abnormal neuroanatomy phenotype, non-suppressible by robo1::robo2^{R1I1+2.UAS.Tag:HA,Tag:SS(wg)}/Scer\GAL4^elav.PLu

(Evans et al., 2015)

Enhancer of

Statement

Reference

comm^Δe39 is an enhancer of abnormal neuroanatomy | embryonic stage phenotype of Tace¹⁹

(Zang et al., 2022)

comm[+]/comm^Δe39 is an enhancer of abnormal neuroanatomy | embryonic stage phenotype of fra⁶/fra⁴

(Yang et al., 2009)

NOT Enhancer of

Statement

Reference

comm^Δe39 is a non-enhancer of abnormal neuroanatomy | embryonic stage phenotype of Tace¹⁹

(Zang et al., 2022)

comm^Δe39/comm^Δe39 is a non-enhancer of abnormal neuroanatomy | embryonic stage | recessive phenotype of robo1¹

(Daiber et al., 2021)

NOT Suppressor of

Statement

Reference

comm^Δe39 is a non-suppressor of abnormal neuroanatomy | embryonic stage phenotype of Tace¹⁹

(Zang et al., 2022)

comm^Δe39/comm^Δe39 is a non-suppressor of abnormal neuroanatomy | recessive | embryonic stage phenotype of robo1¹

(Daiber et al., 2021)

Other

Statement

Reference

comm^Δe39, robo1¹, robo1^Tag:HA has abnormal neuroanatomy | embryonic stage phenotype

(Daiber et al., 2021)

Cele\sax-3^robo1.Tag:HA, comm^Δe39, robo1¹ has abnormal neuroanatomy | recessive | embryonic stage phenotype

(Daiber et al., 2021)

Phenotype Manifest In

Suppressed by

Statement

Reference

comm^Δe39 has symmetrical commissure phenotype, suppressible by robo1::robo2^{R2I1+2.UAS.Tag:HA,Tag:SS(wg)}/Scer\GAL4^elav.PLu

(Evans et al., 2015)

comm^Δe39 has symmetrical commissure phenotype, suppressible by robo2^{UAS.Tag:HA,Tag:SS(wg)}/Scer\GAL4^elav.PLu

(Evans et al., 2015)

comm^Δe39 has larval longitudinal connective | embryonic stage 16 phenotype, suppressible by kuz^unspecified

(Coleman et al., 2010)

comm^Δe39 has commissure | embryonic stage 16 phenotype, suppressible by kuz^unspecified

(Coleman et al., 2010)

comm^Δe39 has midline glial cell phenotype, suppressible by rl^Sem

(Bergmann et al., 2002)

comm^Δe39 has midline glial cell phenotype, suppressible by hid^unspecified

(Bergmann et al., 2002)

NOT suppressed by

Statement

Reference

comm^Δe39 has symmetrical commissure phenotype, non-suppressible by robo1::robo2^{R1I1+2.UAS.Tag:HA,Tag:SS(wg)}/Scer\GAL4^elav.PLu

(Evans et al., 2015)

comm^Δe39 has symmetrical commissure phenotype, non-suppressible by robo2^{ΔIg1.10xUAS.Tag:HA,Tag:SS(wg)}/Scer\GAL4^elav.PLu

(Evans et al., 2015)

comm^Δe39 has symmetrical commissure phenotype, non-suppressible by robo2^{ΔIg2.10xUAS.Tag:HA,Tag:SS(wg)}/Scer\GAL4^elav.PLu

(Evans et al., 2015)

Enhancer of

Statement

Reference

comm^Δe39 is an enhancer of axon | embryonic stage phenotype of Tace¹⁹

(Zang et al., 2022)

comm^Δe39 is an enhancer of larval EW neuron | embryonic stage phenotype of Tace¹⁹

(Zang et al., 2022)

comm[+]/comm^Δe39 is an enhancer of larval EW neuron phenotype of fra⁶/fra⁴

(Yang et al., 2009)

comm^Δe39 is an enhancer of larval longitudinal connective phenotype of robo1^unspecified

(Simpson et al., 2000)

NOT Enhancer of

Statement

Reference

comm^Δe39 is a non-enhancer of larval EW neuron | embryonic stage phenotype of Tace¹⁹

(Zang et al., 2022)

comm^Δe39 is a non-enhancer of axon | embryonic stage phenotype of Tace¹⁹

(Zang et al., 2022)

comm^Δe39/comm^Δe39 is a non-enhancer of embryonic midline of ventral nerve cord phenotype of robo1¹

(Daiber et al., 2021)

comm^Δe39 is a non-enhancer of presumptive embryonic/larval central nervous system phenotype of robo1^unspecified, robo2^unspecified

(Simpson et al., 2000)

comm^Δe39 is a non-enhancer of larval ventral nerve cord phenotype of robo1^unspecified, robo2^unspecified

(Simpson et al., 2000)

comm^Δe39 is a non-enhancer of larval ventral nerve cord commissure phenotype of robo1^unspecified, robo2^unspecified

(Simpson et al., 2000)

comm^Δe39 is a non-enhancer of larval longitudinal connective phenotype of robo1^unspecified, robo2^unspecified

(Simpson et al., 2000)

NOT Suppressor of

Statement

Reference

comm^Δe39 is a non-suppressor of larval EW neuron | embryonic stage phenotype of Tace¹⁹

(Zang et al., 2022)

comm^Δe39 is a non-suppressor of axon | embryonic stage phenotype of Tace¹⁹

(Zang et al., 2022)

comm^Δe39/comm^Δe39 is a non-suppressor of embryonic midline of ventral nerve cord phenotype of robo1¹

(Daiber et al., 2021)

comm^Δe39 is a non-suppressor of presumptive embryonic/larval central nervous system phenotype of robo1^unspecified, robo2^unspecified

(Simpson et al., 2000)

comm^Δe39 is a non-suppressor of larval ventral nerve cord phenotype of robo1^unspecified, robo2^unspecified

(Simpson et al., 2000)

comm^Δe39 is a non-suppressor of larval ventral nerve cord commissure phenotype of robo1^unspecified, robo2^unspecified

(Simpson et al., 2000)

comm^Δe39 is a non-suppressor of larval longitudinal connective phenotype of robo1^unspecified, robo2^unspecified

(Simpson et al., 2000)

Other

Statement

Reference

comm^Δe39, robo1¹, robo1^Tag:HA has embryonic midline of ventral nerve cord phenotype

(Daiber et al., 2021)

comm^Δe39, robo1¹, robo1^Tag:HA has commissure | embryonic stage phenotype

(Daiber et al., 2021)

Cele\sax-3^robo1.Tag:HA, comm^Δe39, robo1¹ has embryonic midline of ventral nerve cord phenotype

(Daiber et al., 2021)

Cele\sax-3^robo1.Tag:HA, comm^Δe39, robo1¹ has commissure | embryonic stage phenotype

(Daiber et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of either robo2^{ΔIg1.10xScer\UAS.T:Ivir\HA1,T:SS-wg}, robo2^{ΔIg2.10xScer\UAS.T:Ivir\HA1,T:SS-wg} or robo1::robo2^{R1I1+2.Scer\UAS.T:Ivir\HA1,T:SS-wg} under the control of Scer\GAL4^elav.PLu does not suppress the loss of commissure phenotype of homozygous comm^E39 embryos.

Expression of robo1::robo2^{R2I1+2.Scer\UAS.T:Ivir\HA1,T:SS-wg} under the control of Scer\GAL4^elav.PLu strongly suppresses the loss of commissure phenotype of homozygous comm^E39 embryos.

Expression of robo2^{Scer\UAS.T:Ivir\HA1,T:SS-wg} under the control of Scer\GAL4^sli.PS suppresses the loss of commissure phenotype of homozygous comm^E39 embryos.

(Evans et al., 2015)

kuz^unspecified partially suppresses the loss of commissures seen in comm^Δe39 homozygous stage 16 embryos, although most axons are still unable to cross the midline.

(Coleman et al., 2010)

The commissural defects seen in fra⁴/fra⁶ embryos are enhanced in a heterozygous comm^E39/+ genetic background as shown by missing and thin commissures in many segments, as well as an increased frequency of non-crossing defects in a subset of of commissural neurons.

(Yang et al., 2009)

The reduction in midline glial cell numbers seen in comm^Δe39 mutant embryos is suppressed in double mutants with W^unspecified or rl^Sem. These rescued midline glial cells are scattered throughout the midline, which lacks axons in these animals.

(Bergmann et al., 2002)

In a robo^unspecified/comm^Δe39 double mutant embryo, the intermediate Fas2 pathways is also perturbed and can be seen crossing the midline. Embryos homozygous mutant for robo^unspecified and lea^unspecified show a compressed midline where all the axons approach the midline and cannot leave. The addition of comm^Δe39 does not effect this phenotype.

(Simpson et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Not rescued by

comm^Δe39 is not rescued by comm^UAS.cKa/Scer\GAL4^sim.P3.7

(Georgiou and Tear, 2002)

comm^Δe39 is not rescued by comm^UAS.cKa/Scer\GAL4^sli.PS

(Georgiou and Tear, 2002)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

FlyBase curator comment: FBrf0254852 says that FBal0097023 and FBal0141222 are the same allele, based on a personal communication from G. Tear. Merged these alleles here.

(Sharrock et al., 2022)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

comm<up>Delta e39</up>

(Sharrock et al., 2022)

comm^E39

(Daiber et al., 2021, Evans et al., 2015)

comm^e39

(Zang et al., 2022, Yang et al., 2009)

comm^Δe39

(van den Brink et al., 2013, Coleman et al., 2010, Ing et al., 2007)

Δe39

(Simpson et al., 2000)

Name Synonyms

Secondary FlyBase IDs

FBal0097023
FBal0141222

References (15)

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