FlyBase Allele Report: Hsap\SUPT16H[Ref.UAS]

General Information

Symbol

Hsap\SUPT16H^Ref.UAS

Species

H. sapiens

Name

FlyBase ID

FBal0388811

Feature type

allele

Associated gene

Hsap\SUPT16H

Associated Insertion(s)

Carried in Construct

PBac{UAS-hSUPT16H.Ref}

Key Links

Transgenic product class

wild_type

(Ma et al., 2023)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Ma et al., 2023)

Mutagen

in vitro construct

(Ma et al., 2023)

Progenitor genotype

Carried in construct

PBac{UAS-hSUPT16H.Ref}

Cytology

Description

UAS regulates expression of Hsap\SUPT16H reference cDNA sequence (XM_011536381).

(Ma et al., 2023)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\SUPT16H

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates neurodevelopmental disorder with dysmorphic facies and thin corpus callosum

modeled by dre4^KO1

(Ma et al., 2023)

modeled by dre4^GL00017

(Ma et al., 2023)

modeled by dre4^HMS01332

(Ma et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable, with Scer\GAL4^Act5C.PI

(Ma et al., 2023)

viable, with Scer\GAL4^da.G32

(Ma et al., 2023)

viable, with Scer\GAL4^αTub84B.PL

(Ma et al., 2023)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Hsap\SUPT16H^Ref.UAS, Scer\GAL4^elav.PLu is a suppressor | partially of short lived phenotype of Scer\GAL4^elav.PLu, dre4^HMS01332

(Ma et al., 2023)

Hsap\SUPT16H^Ref.UAS, Scer\GAL4^repo is a suppressor of lethal - all die during P-stage phenotype of Scer\GAL4^repo, dre4^GL00017

(Ma et al., 2023)

Hsap\SUPT16H^Ref.UAS, Scer\GAL4^ey.PH is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^ey.PH, dre4^GL00017

(Ma et al., 2023)

Hsap\SUPT16H^Ref.UAS, Scer\GAL4^nub.PK is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^nub.PK, dre4^GL00017

(Ma et al., 2023)

Hsap\SUPT16H^Ref.UAS, Scer\GAL4^Act5C.PP is a suppressor of decreased cell size | somatic clone | larval stage phenotype of Scer\GAL4^Act5C.PP, dre4^GL00017

(Ma et al., 2023)

NOT Suppressor of

Statement

Reference

Scer\GAL4^Act5C.PP/Hsap\SUPT16H^Ref.UAS is a non-suppressor of lethal - all die before end of second instar larval stage phenotype of dre4^KO1

(Ma et al., 2023)

Scer\GAL4^Act5C.PP/Hsap\SUPT16H^Ref.UAS is a non-suppressor of some die during first instar larval stage phenotype of dre4^KO1

(Ma et al., 2023)

Scer\GAL4^Act5C.PP/Hsap\SUPT16H^Ref.UAS is a non-suppressor of some die during second instar larval stage phenotype of dre4^KO1

(Ma et al., 2023)

Other

Statement

Reference

Hsap\SUPT16H^Ref.UAS, Scer\GAL4^Act5C.PP, dre4^GL00017 has lethal - all die before end of P-stage phenotype

(Ma et al., 2023)

Hsap\SUPT16H^Ref.UAS, Scer\GAL4^Act5C.PP, dre4^HMS01332 has lethal - all die before end of P-stage phenotype

(Ma et al., 2023)

Phenotype Manifest In

Suppressor of

Statement

Reference

Hsap\SUPT16H^Ref.UAS, Scer\GAL4^ey.PH is a suppressor | partially of adult head | absent phenotype of Scer\GAL4^ey.PH, dre4^GL00017

(Ma et al., 2023)

Hsap\SUPT16H^Ref.UAS, Scer\GAL4^nub.PK is a suppressor | partially of wing | absent phenotype of Scer\GAL4^nub.PK, dre4^GL00017

(Ma et al., 2023)

Hsap\SUPT16H^Ref.UAS, Scer\GAL4^Act5C.PP is a suppressor of larval fat cell of larval fat body phenotype of Scer\GAL4^Act5C.PP, dre4^GL00017

(Ma et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Hsap\SUPT16H^Ref.UAS

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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