FB2025_01 , released February 20, 2025
Allele: Avic\GFPEGFP.PLCD1(PH-S39R).UAS
Open Close
General Information
Symbol
Avic\GFPEGFP.PLCD1(PH-S39R).UAS
Species
A. victoria
Name
FlyBase ID
FBal0392361
Feature type
allele
Associated gene
Avic\GFP
Associated Insertion(s)
Carried in Construct
P{UAS-PLCδ-PH.S39R-EGFP}
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Khuong et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-PLCδ-PH.S39R-EGFP}
Cytology
Description

UAS regulatory sequences drive expression of EGFP which is fused to a mutated form of the pleckstrin homology (PH) domain of Hsap\PLCD1 (this PH domain can no longer bind phosphatidylinositol 4,5 bisphosphate).

(Khuong et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
EGFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\PLCD1PH.S39R.Scer\UAS.T:Avic\GFP-EGFP in third instar larvae under the control of either Scer\GAL4n-syb.PS or Scer\GAL4D42 does not result in neuromuscular junction overgrowth.

      (Khuong et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsap\PLCD1PH.S39R.Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4n-syb.PS does not enhance the neuromuscular junction overgrowth phenotype seen in tweek1/tweek2 third instar larvae.

      Expression of Hsap\PLCD1PH.S39R.Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4n-syb.PS does not enhance the neuromuscular overgrowth seen in WASp1/Df(3R)3450 third instar larvae.

      (Khuong et al., 2010)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Avic\GFPEGFP.PLCD1(PH-S39R).UAS
      Hsap\PLCD1PH.S39R.Scer\UAS.T:Avic\GFP-EGFP
      Hsap\PLCD1PH.S39R.UAS.EGFP
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0392316
      • FBal0264518
      References (3)