FlyBase Allele Report: Hsap\SETX[UAS.Tag:FLAG]

FB2025_01 , released February 20, 2025

FB2025_01 , released February 20, 2025

Allele: Hsap\SETX^UAS.Tag:FLAG

General Information

Symbol

Hsap\SETX^UAS.Tag:FLAG

Species

H. sapiens

Name

FlyBase ID

FBal0396461

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

P{UAS-hSETX.FLAG}

Key Links

Transgenic product class

(Bennett et al., 2023)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Bennett et al., 2023)

Mutagen

in vitro construct

(Bennett et al., 2023)

Progenitor genotype

Carried in construct

P{UAS-hSETX.FLAG}

Cytology

Description

UASt regulatory sequences drive expression of wild-type Hsap\SETX that is tagged with Tag:FLAG.

(Bennett et al., 2023)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Tagged with

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates frontotemporal dementia and/or amyotrophic lateral sclerosis 1

modeled by Zzzz\poly-GR^50.UAS.EGFP

(Bennett et al., 2023)

modeled by Zzzz\GGGGCC^58.UAS.EGFP

(Bennett et al., 2023)

modeled by Zzzz\poly-GR^{1136.UAS.EGFP}

(Bennett et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of larval stage, with Scer\GAL4^tsh.PU

(Bennett et al., 2023)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Hsap\SETX^UAS.Tag:FLAG, Scer\GAL4^GMR.PU is a suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.PU, Zzzz\GGGGCC^58.UAS.EGFP

(Bennett et al., 2023)

Hsap\SETX^UAS.Tag:FLAG, Scer\GAL4^nSyb.PS is a suppressor | partially of decreased rate of adult locomotory behavior phenotype of Scer\GAL4^nSyb.PS, Zzzz\poly-GR^{1136.UAS.EGFP}

(Bennett et al., 2023)

Hsap\SETX^UAS.Tag:FLAG, Scer\GAL4^GMR.PU is a suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.PU, Zzzz\poly-GR^50.UAS.EGFP

(Bennett et al., 2023)

Hsap\SETX^UAS.Tag:FLAG, Scer\GAL4^GMR.PU is a suppressor of increased mortality during development phenotype of Scer\GAL4^GMR.PU, Zzzz\poly-GR^50.UAS.EGFP

(Bennett et al., 2023)

Phenotype Manifest In

Suppressor of

Statement

Reference

Hsap\SETX^UAS.Tag:FLAG, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\GGGGCC^58.UAS.EGFP

(Bennett et al., 2023)

Hsap\SETX^UAS.Tag:FLAG, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\poly-GR^50.UAS.EGFP

(Bennett et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Hsap\SETX^UAS.Tag:FLAG

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections