FlyBase Allele Report: Hsap\TBP[63Q.UAS.Tag:HA]

FB2025_02 , released April 17, 2025

FB2025_02 , released April 17, 2025

Allele: Hsap\TBP^{63Q.UAS.Tag:HA}

General Information

Symbol

Hsap\TBP^{63Q.UAS.Tag:HA}

Species

H. sapiens

Name

FlyBase ID

FBal0397030

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

P{UAS-hTBP.63Q.HA}

Key Links

Transgenic product class

trinucleotide_repeat_expansion

(Patel et al., 2023)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

trinucleotide_repeat_expansion

(Patel et al., 2023)

Mutagen

in vitro construct

(Patel et al., 2023)

Progenitor genotype

Carried in construct

P{UAS-hTBP.63Q.HA}

Cytology

Description

UAS regulatory sequences drive expression of polyQ-expanded (Q63) Hsap\TBP tagged with a C-terminal Tag:HA.

(Patel et al., 2023)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Tagged with

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of spinocerebellar ataxia type 17

CEA

(Patel et al., 2023)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate, with Scer\GAL4^sqh.PU

(Patel et al., 2023)

decreased rate of adult locomotory behavior, with Scer\GAL4^{elav.Switch.PO}

(Patel et al., 2023)

decreased rate of adult locomotory behavior, with Scer\GAL4^GS.repo

(Patel et al., 2023)

decreased rate of adult locomotory behavior, with Scer\GAL4^sqh.PU

(Patel et al., 2023)

majority die during P-stage, with Scer\GAL4^sqh.PU

(Patel et al., 2023)

partially lethal - majority die, with Scer\GAL4^sqh.PU

(Patel et al., 2023)

short lived, with Scer\GAL4^sqh.PU

(Patel et al., 2023)

short lived | female | RU486 conditional, with Scer\GAL4^{Tub.Switch.PU}

(Patel et al., 2023)

short lived | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Patel et al., 2023)

short lived | RU486 conditional, with Scer\GAL4^GS.repo

(Patel et al., 2023)

some die during embryonic stage, with Scer\GAL4^sqh.PU

(Patel et al., 2023)

visible | adult stage | progressive, with Scer\GAL4^GMR.long

(Patel et al., 2023)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.long

(Patel et al., 2023)

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Hsap\TBP^{63Q.UAS.Tag:HA}

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections