FlyBase Allele Report: Dmel\AttA[UAS.APEX2,Tag:HA]

General Information

Symbol

Dmel\AttA^{UAS.APEX2,Tag:HA}

Species

D. melanogaster

Name

FlyBase ID

FBal0397103

Feature type

allele

Associated gene

Dmel\AttA

Associated Insertion(s)

Carried in Construct

P{UAS-AttA.APEX2.FLAG}

Key Links

Transgenic product class

genomic_DNA

(Hsieh and Chiang, 2023)

wild_type

(Hsieh and Chiang, 2023)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

genomic_DNA

(Hsieh and Chiang, 2023)

wild_type

(Hsieh and Chiang, 2023)

Mutagen

in vitro construct

(Hsieh and Chiang, 2023)

Progenitor genotype

Carried in construct

P{UAS-AttA.APEX2.FLAG}

Cytology

Description

UASt regulatory sequences drive expression of AttA that is tagged with APEX2 and Tag:FLAG.

(Hsieh and Chiang, 2023)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

AttA

Tagged with

APEX2

reporter enzyme

proximity labeling tool (protein)

Tag:FLAG

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{Arctic.Aβ42.lexAop.Tag:SS(nec)}

(Hsieh and Chiang, 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

AttA^{UAS.APEX2,Tag:HA}, Scer\GAL4^elav.PU is a non-enhancer of short lived phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Scer\GAL4^elav.PU

(Hsieh and Chiang, 2023)

AttA^{UAS.APEX2,Tag:HA}, Scer\GAL4^elav.PU is a non-enhancer of decreased efficacy of learning | adult stage phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Scer\GAL4^elav.PU

(Hsieh and Chiang, 2023)

Suppressor of

Statement

Reference

Scer\GAL4^NP0001/AttA^{UAS.APEX2,Tag:HA} is a suppressor | partially of decreased efficacy of learning | adult stage phenotype of Ecol\lexA^nSyb.PU, Hsap\APP^{Arctic.Aβ42.lexAop.Tag:SS(nec)}

(Hsieh and Chiang, 2023)

Scer\GAL4^NP0001/AttA^{UAS.APEX2,Tag:HA} is a suppressor | partially of short lived phenotype of Ecol\lexA^nSyb.PU, Hsap\APP^{Arctic.Aβ42.lexAop.Tag:SS(nec)}

(Hsieh and Chiang, 2023)

NOT Suppressor of

Statement

Reference

AttA^{UAS.APEX2,Tag:HA}, Scer\GAL4^elav.PU is a non-suppressor of short lived phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Scer\GAL4^elav.PU

(Hsieh and Chiang, 2023)

AttA^{UAS.APEX2,Tag:HA}, Scer\GAL4^elav.PU is a non-suppressor of decreased efficacy of learning | adult stage phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Scer\GAL4^elav.PU

(Hsieh and Chiang, 2023)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^NP0001/AttA^{UAS.APEX2,Tag:HA} is a suppressor of adult gut phenotype of Ecol\lexA^nSyb.PU, Hsap\APP^{Arctic.Aβ42.lexAop.Tag:SS(nec)}

(Hsieh and Chiang, 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

AttA^{UAS.APEX2,Tag:HA}

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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