FlyBase Allele Report: Dmel\Ser[1]

General Information

Symbol

Dmel\Ser¹

Species

D. melanogaster

Name

FlyBase ID

FBal0398912

Feature type

allele

Associated gene

Dmel\Ser

Associated Insertion(s)

Tirant{}Ser¹

Carried in Construct

Also Known As

Bd^S

Key Links

Genomic Maps

JBrowse

Allele class

neomorphic allele - genetic evidence

gain of function allele

Mutagen

spontaneous

Nature of the Allele

Allele class

gain of function allele

(Murata et al., 1996, Thomas et al., 1991)

neomorphic allele - genetic evidence

(Fleming et al., 1990)

Mutagen

spontaneous

(Thomas et al., 1995, Lindsley and Zimm, 1992, Thomas et al., 1991)

Progenitor genotype

Associated Insertion(s)

Tirant{}Ser¹

Cytology

Description

Insertion of a Tirant element in the Ser 3'UTR (coordinates 3R:27172910..27172913 , release 6 genome).

(Miller et al., 2016)

Insertion of a 5.5kb Tirant element in the 3' untranslated region of the last exon 81bp downstream of the translational stop codon, resulting in truncation of the Ser RNA eliminating putative RNA degradation signals.

(Thomas et al., 1995)

5.5-kb insert at 0 to 3.0 kb.

(Lindsley and Zimm, 1992)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:27,172,910..27,172,913 3R:27,172,910..27,172,913

(Miller et al., 2016, Sivasankaran et al., 2000, Hukriede and Fleming, 1997, Murata et al., 1996, Thomas, 1995.9.26, Thomas et al., 1995, FlyBase, 1992-, Lindsley and Zimm, 1992)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

S77925

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Schimke immuno-osseous dysplasia

modeled by Marcal1^UAS.cBa

(Morimoto et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Hukriede and Fleming, 1997)

viable | recessive

(Lindsley and Zimm, 1992)

visible | adult stage

(Kanda et al., 2013)

visible | dominant

(Shyamala and Chopra, 1999, Hukriede and Fleming, 1997, Sotillos et al., 1997, Murata et al., 1996, Thomas et al., 1995, Fleming et al., 1990)

Phenotype Manifest In

wing

(Tsuda et al., 2002, Shyamala and Chopra, 1999, Sotillos et al., 1997, Murata et al., 1996, Thomas et al., 1995, Lindsley and Zimm, 1992)

wing | distal

(Hukriede and Fleming, 1997)

wing margin

(Kanda et al., 2013, Dalton et al., 2011, Herz et al., 2010)

Detailed Description

Statement

Reference

Ser¹/+ adults display a wing-notching phenotype.

(Kanda et al., 2013)

Ser¹/+ wings have a notched phenotype.

(Dalton et al., 2011)

Heterozygotes exhibit a wing notching phenotype.

(Herz et al., 2010)

Heterozygotes show slight scalloping of the wing blade along the tip and towards the posterior margin.

(Shyamala and Chopra, 1999)

Wing margin phenotype not affected by Su(dx)^sp.

(Fostier et al., 1998)

Heterozygotes exhibit loss of distal wing margin material, phenotype is enhanced in homozygotes. Ser^Bd-3/Ser^D transheterozygotes exhibit loss of distal wing margin material, similar to Ser^D heterozygotes.

(Hukriede and Fleming, 1997)

Heterozygotes show notching of the wing, in particular in between the second and fifth wing veins.

(Murata et al., 1996)

Homozygotes and heterozygotes exhibit scalloping of the wing margin due to cell death during pupal stages.

(Thomas et al., 1995)

Wings of Ser¹/+ and hemizygous Ser¹ notched at tip; deepest notch at second posterior cell. In triploids, one dose of Ser¹ overlaps wild type. As with other Ser alleles expression suppressed by H and N. Dominant wing phenotype; homozygous viable.

(Lindsley and Zimm, 1992)

Hemizygotes and homozygotes are viable. Notches on wing tip between the third and fifth vein. Penetrance and expressivity of phenotype in heterzygotes is slightly affected by temperature: fully penetrant at 18^oC and weaker at 28^oC.

(Thomas et al., 1991)

Heterozygotes have wing notches in the adult: dominant wing-nicking phenotype. Ser^D/N^nd-1 transheterozygotes display a synergistic phenotype: loss of anterior and posterior wing margins and loss of distal wing blade tissue. Ser^D/Dp(1;2)51bV76e flies have wild type wings.

(Fleming et al., 1990)

Ser¹ is homozygous viable; initially thought to be homozygous lethal, but lethality removable by recombination; the closely linked lethal persists in many Ser¹-bearing chromosomes. Homozygous Ser¹ produces extreme incision of wing margins especially in second posterior cell.

(Belt, 1971)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Ser¹ has visible | dominant phenotype, enhanceable by sd^SG29.1

(Shyamala and Chopra, 1999)

Ser¹ has visible | dominant phenotype, enhanceable by kuz^k01405/kuz^1405Rev4

(Sotillos et al., 1997)

Suppressed by

Statement

Reference

Ser¹ has visible | adult stage phenotype, suppressible by trr[+]/trr^K662X

(Kanda et al., 2013)

Other

Statement

Reference

Ser¹/Ser[+], e(r)^27-1 has viable phenotype

(Tsubota et al., 2011)

Ser¹, kuz^k01405 has visible | recessive phenotype

(Sotillos et al., 1997)

Phenotype Manifest In

Enhanced by

Statement

Reference

Ser¹ has wing phenotype, enhanceable by rn^GAL4-13

(St Pierre et al., 2002)

Ser¹ has wing phenotype, enhanceable by rn^GAL4-14

(St Pierre et al., 2002)

Ser¹ has wing phenotype, enhanceable by rn^GAL4-5

(St Pierre et al., 2002)

Ser¹ has wing phenotype, enhanceable by ebi^E4

(Tsuda et al., 2002)

Ser¹ has wing phenotype, enhanceable by fz3^unspecified

(Sivasankaran et al., 2000)

Ser¹ has wing phenotype, enhanceable by sd^SG29.1

(Shyamala and Chopra, 1999)

Ser¹ has wing phenotype, enhanceable by kuz^k01405/kuz^1405Rev4

(Sotillos et al., 1997)

Ser¹ has wing phenotype, enhanceable by hrg^P1

(Murata et al., 1996)

Suppressed by

Statement

Reference

Ser¹ has wing margin phenotype, suppressible by trr[+]/trr^K662X

(Kanda et al., 2013)

Ser¹ has wing margin phenotype, suppressible by Ndfip^UAS.Tag:HA/Scer\GAL4^Bx-MS1096

(Dalton et al., 2011)

Ser¹ has wing margin phenotype, suppressible by Utx[+]/Utx¹

(Herz et al., 2010)

Ser¹ has wing margin phenotype, suppressible by Utx²/Utx[+]

(Herz et al., 2010)

Ser¹ has wing margin phenotype, suppressible by Utx^f01321/Utx[+]

(Herz et al., 2010)

Enhancer of

Statement

Reference

Ser¹ is an enhancer of wing phenotype of hrg^P1

(Murata et al., 1996)

Other

Statement

Reference

Ser¹, kuz^k01405 has wing phenotype

(Sotillos et al., 1997)

Ser¹, hrg^P1 has wing vein L1 phenotype

(Murata et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

The wing-notching phenotype characteristic for Ser¹/+ adult flies is partially suppressed by combination with a single copy of trr^K662X.

(Kanda et al., 2013)

The Ser¹/+ wing phenotype is suppressed by Scer\GAL4^Bx-MS1096-mediated overexpression of Ndfip^{Scer\UAS.T:Ivir\HA1}.

(Dalton et al., 2011)

The wing notching phenotype of Ser¹ heterozygotes is dominantly suppressed by Utx¹, Utx² and Utx^f01321.

(Herz et al., 2010)

The wing notching phenotype seen in Ser^D/+ animals is enhanced by the addition of ebi^E4.

(Tsuda et al., 2002)

Addition of fz3^unspecified to Ser^D flies enhances the wing notching phenotype seen in these flies. A second copy of fz3^unspecified enhances this phenotype further and results in additional posterior margin notching.

(Sivasankaran et al., 2000)

sd^SG29.1/+ ; Ser^D/+ flies show an enhancement of wing scalloping with a total loss of sensory bristles along the posterior margin and the loss of some bristles along the anterior margin. Hemizygous sd^SG29.1 in combination with Ser^D/+ results in a deeply scalloped posterior margin. Sensory bristles are completely lost from the posterior margin and there are very few bristles along the anterior margin.

(Shyamala and Chopra, 1999)

The scalloping of the wing margin seen in Ser^D/+ heterozygotes is enhanced if the flies also carry kuz^1405Rev4/kuz^k01405.

(Sotillos et al., 1997)

hrg^P1/hrg^P1; Ser^D/+ flies show synergistic enhancement of the notched wing phenotype, with deeper wing notching than is seen in either hrg^P1/hrg^P1 or Ser^D/+ single mutant flies, and loss of most of the first wing vein. The notching is also not restricted to sites between the second and fifth wing vein. The 'delta' phenotype and wing confluence phenotype of Df(3R)Dl-FX3 flies is suppressed by Ser^D.

(Murata et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (7,928)

81122

3354

5915

6411

5744

Dp(3;3)Cam32/TM3, Ser¹

2371

flr³/TM3, Ser¹

3355

Df(3R)kar-Sz8/TM3, Ser¹

80072

106998

108484

108775

108400

Dp(3;3)Cam32/TM3, Ser¹

More stocks available...

Notes on Origin

Discoverer

Spencer, 7th Dec. 1935.

(Lindsley and Zimm, 1992)

Comments

Ser^D protein has increased stability.

(Thomas et al., 1995)

External Crossreferences and Linkouts ( 1 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

S77925

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Bd^S

(Mendanha et al., 2010, Coyle-Thompson and Banerjee, 1993, Lindsley and Zimm, 1992)

Ser¹

(He et al., 2023, Miller et al., 2016, Morimoto et al., 2016, LeBon et al., 2014, Kanda et al., 2013, Dalton et al., 2011, Tsubota et al., 2011, Herz et al., 2010, Ozdowski et al., 2009)

Ser^Bd

(Speicher et al., 1994)

Ser^D

Name Synonyms

Secondary FlyBase IDs

FBal0015427
FBal0030220

References (43)

Report Sections

Open Close