FlyBase Allele Report: Dmel\Dark[RNAi.UAS.cUa]

General Information

Symbol

Dmel\Dark^RNAi.UAS.cUa

Species

D. melanogaster

Name

FlyBase ID

FBal0407432

Feature type

allele

Associated gene

Dmel\Dark

Associated Insertion(s)

Carried in Construct

P{UAS-Dark.RNAi.U}

Key Links

Transgenic product class

RNAi_reagent

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-Dark.RNAi.U}

Cytology

Description

UAS regulatory sequences drive expression of an RNAi construct targeting Dark.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Dark

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Dark^RNAi.UAS.cUa, Scer\GAL4^CCAP.PP is a suppressor | partially of visible phenotype of Idh^{R195H.UAS.Tag:FLAG}, Scer\GAL4^CCAP.PP

(Reitman et al., 2015)

Dark^RNAi.UAS.cUa, Scer\GAL4^hh.PU is a suppressor of increased cell death phenotype of Scer\GAL4^hh.PU, bsk^KK108156, mad2^GD16427

(Wong et al., 2014)

Dark^RNAi.UAS.cUa, Scer\GAL4^en.PU is a suppressor of increased cell death phenotype of Scer\GAL4^en.PU, bsk^KK108156, mad2^GD16427

(Wong et al., 2014)

Other

Statement

Reference

Dark^RNAi.UAS.cUa, Scer\GAL4^hh.PU, bsk^GD10555, mad2^GD16427 has increased cell death phenotype

(Wong et al., 2014)

Dark^RNAi.UAS.cUa, Scer\GAL4^en.PU, bsk^GD10555, mad2^GD16427 has increased cell death phenotype

(Wong et al., 2014)

Phenotype Manifest In

Suppressor of

Statement

Reference

Dark^RNAi.UAS.cUa, Scer\GAL4^CCAP.PP is a suppressor | partially of wing phenotype of Idh^{R195H.UAS.Tag:FLAG}, Scer\GAL4^CCAP.PP

(Reitman et al., 2015)

Dark^RNAi.UAS.cUa, Scer\GAL4^hh.PU is a suppressor of wing disc phenotype of Scer\GAL4^hh.PU, bsk^KK108156, mad2^GD16427

(Wong et al., 2014)

Dark^RNAi.UAS.cUa, Scer\GAL4^en.PU is a suppressor of wing disc phenotype of Scer\GAL4^en.PU, bsk^KK108156, mad2^GD16427

(Wong et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Knockdown of Dark, through expression of Dark^VDRC.cUa results in significantly reduced levels of cell death in imaginal wing disc cells expressing bsk^KK108156 and mad2^GD16427.

(Wong et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Dark^RNAi.UAS.cUa

Dark^VDRC.cUa

Dark^{dsRNA.Scer\UAS.cUa}

Dark^{dsRNA.UAS.cUa}

Name Synonyms

Secondary FlyBase IDs

FBal0316560
FBal0298983

References (7)

Report Sections

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