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General Information
Name
TWO-PORE DOMAIN K+ CHANNEL SUBUNITS
Species
D. melanogaster
Symbol
K2P
FlyBase ID
FBgg0000045
Date last reviewed
2013-03-09
Number of members
10
Description
Description

The two-pore domain K+ (K2P) channels possess four transmembrane domains and two pore domains; they assemble as dimers. K2P channels have been implicated in a number of processes such as maintaining resting potential (leak K+ conductance), responding to volatile anesthetics, chemo- and mechanosensation. (Adapted from FBrf0188365 and PMID:11121510).

Notes on Group

CG42340 is omitted as FBrf0192007 states that although it displays substantial similarity to K2P channel sequences it only has a single conserved pore forming domain surrounded by two transmembrane segments.

Source Material
The TWO-PORE DOMAIN K+ CHANNEL SUBUNITS Gene Group has been compiled by FlyBase curators using the following publication(s): Chintapalli et al., 2013, Döring et al., 2006, and Buckingham et al., 2005 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
Related Gene Groups
Members (10)
For all members:
External Data
Synonyms and Secondary IDs
Synonym(s)
K2P
Two-pore domain potassium channels
Tandem of P-domains in a Weakly Inward rectifying K+ channel-related channels
K2P
TWIK
TWO-PORE DOMAIN K+ CHANNELS
TWO-PORE DOMAIN K+ CHANNEL SUBUNITS
Secondary FlyBase ID(s)
References (4)