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General Information
Name
ESCRT-III COMPLEX
Species
D. melanogaster
Symbol
ESCRT-III
FlyBase ID
FBgg0000057
Date last reviewed
2015-08-24
Number of members
8
Description
Description

The ESCRT (Endosomal Sorting Complexes Required for Transport) machinery is made up of five complexes, ESCRT-0 to -III and the Vps4-Vta1 ATPase complex, which are sequentially recruited to the cytosolic face of the membrane, and mediate cargo recognition, membrane budding and fission. ESCRT-III is a dynamic complex, that assembles on endosomes. The components of the complex are less well defined, but it has four core subunits. It assembles into a filament around the neck of the budding vesicle. ESCRT-III mediates the recruitment of deubiquitinases and, together with the Vps4-Vta1 complex, which it recruits, mediates membrane scission. (Adapted from PMID:22361144 and FBrf0209668).

Notes on Group

The ESCRT-III gene group lists the core and accessory proteins of ESCRT-III. In D.mel two there are two genes homologous to yeast Did4 (Vps2), Vps2 and CHMP2B.

Source Material
The ESCRT-III COMPLEX Gene Group has been compiled by FlyBase curators using the following publication(s): Li and Blissard, 2015, Capalbo et al., 2012, Michelet et al., 2010, and Vaccari et al., 2009 .
Key Gene Ontology (GO) terms
Molecular Function
Cellular Component
Related Gene Groups
Members (8)
For all members:
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
ESCRT-III
ESCRT-III COMPLEX
Endosomal Sorting Complex Required for Transport III
Charged Multivesicular Body Proteins
ESCRT III
CHMPs
Secondary FlyBase ID(s)
References (5)