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General Information
Name
SMC5/6 COMPLEX
Species
D. melanogaster
Symbol
SMC5-6
FlyBase ID
FBgg0000060
Date last reviewed
2014-07-10
Number of members
7
Description
Description
The SMC5/6 protein complex consists of a Structural Maintenance of Chromosomes (SMC) heterodimer and Non-Smc-Element (Nse) proteins. It is important for genome stability and is required for homologous DNA recombination-based processes. The complex contains a SUMO-ligase and a putative ubiquitin-ligase. (Adapted from FBrf0221151 and PMID:19308705).
Notes on Group

The existence of this complex in D.mel is inferred by orthogy and mutations in subunits that effect genome stability. In yeast, the Smc5/6 complex is made up of eight subunits that form three sub-complexes: Smc6-Smc5-Nse2, Nse1-Nse3-Nse4, and Nse5-Nse6. Nse5 and Nse6 have no counterparts in higher eukaryotes (FBrf0221151).

Source Material
The SMC5/6 COMPLEX Gene Group has been compiled by FlyBase curators using the following publication(s): Li et al., 2013, Li et al., 2013, and Hirano, 2012 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
Cellular Component
Related Gene Groups
Parent group(s)
Members (7)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
java no jive
Smc6, HU- or caffeine-sensitive 95E, huc95E
Structural maintenance of chromosomes 5
External Data
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
SMC5-6
SMC5/6 COMPLEX
Smc5/Smc6/MAGE Complex
Smc5/6 protein complex
SMC5/6
Secondary FlyBase ID(s)
References (4)