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General Information
Name
FRIZZLED-TYPE RECEPTORS
Species
D. melanogaster
Symbol
FZ
FlyBase ID
FBgg0000090
Date last reviewed
2013-08-15
Number of members
4
Description
Description

The frizzled gene family belong to Class F GPCRs. Frizzled GPCRs are characterized by a large N-terminal extracellular domain containing a cysteine-rich ligand-binding domain. The frizzled genes were first identified in Drosophila. Frizzled proteins are receptors for secreted Wnt proteins, as well as other ligands, and also play a critical role in the regulation of cell polarity. Frizzleds function in three distinct signaling pathways - the planar cell polarity pathway, the canonical Wnt/β-catenin pathway, and the Wnt/calcium pathway. (Adapted from FBrf0222139).

Notes on Group
Source Material
The FRIZZLED-TYPE RECEPTORS Gene Group has been compiled by FlyBase curators using the following publication(s): Huang and Klein, 2004 and Brody and Cravchik, 2000 .
Key Gene Ontology (GO) terms
Biological Process
Related Gene Groups
Parent group(s)
Members (4)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
frizzled
Fz1, Dfz1, Frizzled 1, frz, DFz
frizzled 2
Dfz2, Dfrz2, fz-2, Dfrizzled2, DFz-2
frizzled 3
Dfz3, EG:34F3.6, Dfrizzled-3
External Data
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
FZ
FRIZZLED-TYPE RECEPTORS
Frizzled
Frizzleds
Wnt receptor
Secondary FlyBase ID(s)
References (3)