FB2025_02 , released April 17, 2025
Complex: RZZ COMPLEX
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General Information
Name
RZZ COMPLEX
Species
D. melanogaster
Symbol
RZZ
FlyBase ID
FBgg0000096
Date last reviewed
2023-08-08
Number of members
3
Description
Description
The RZZ (Rod, Zwilch and Zw10) complex is a kinetochore component that plays an essential role in spindle assembly checkpoint, blocking the metaphase-to-anaphase transition until all chromosomes properly aligned in a metaphase plate. In mammalian cells, the RZZ complex has a fourth component, Zwint-1. (Adapted from FBrf0219791).
Notes on Group
Source Material
The RZZ COMPLEX Gene Group has been compiled using the following publication(s): Wainman et al., 2012, Karess, 2005, and Williams et al., 2003 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
spindle assembly checkpoint signaling
Cellular Component
RZZ complex
Related Gene Groups
Members (3)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
RZZ
RZZ COMPLEX
Rod-Zwilch-Zw10 complex
Secondary FlyBase ID(s)
References (4)