FB2020_06, released Dec 22, 2020

Gene Group : CASPASES

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General Information
Name
CASPASES
Species
D. melanogaster
Symbol
CASP
FlyBase ID
FBgg0000100
Date last reviewed
2020-06-08
Number of members
7
Description
Description

Caspases are a family of cysteine proteases that are particularly well known for their role in apoptosis. Caspases are translated as inactive zymogen precursor proteins. Initiator caspases have a large prodomain, and are cleaved to yield active enzyme in response to proapoptotic stimuli. Initiator caspases cleave and active effector (or executioner) caspases which cleave the substrates leading to programmed cell death. Caspases belong to MEROPS family C14. (Adapted from FBrf0215539).

Notes on Group

Dronc is the initiator caspase subunit of the apoptosome complex.

Source Material
The CASPASES Gene Group has been compiled by FlyBase curators using the following publication(s): Xu et al., 2009, Harvey et al., 2001, and Rawlings and Barrett, 1996- .
Key Gene Ontology (GO) terms
Molecular Function
cysteine-type endopeptidase activity involved in apoptotic process
Biological Process
apoptotic process
proteolysis
Cellular Component
Related Gene Groups
Parent group(s)
CYSTEINE PEPTIDASES
Protein Complex group(s)
APOPTOSOME
Other related group(s)
INHIBITOR OF APOPTOSIS
Members (7)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Damm
Death associated molecule related to Mch2 caspase
Daydream, Death associated molecule related to Mch2
(FlyBase, 2017-, Xu et al., 2009, Harvey et al., 2001, Rawlings and Barrett, 1996-)
Dcp-1
Death caspase-1
Dcp1, caspase-1, caspase
(FlyBase, 2017-, Xu et al., 2009, Harvey et al., 2001, Rawlings and Barrett, 1996-)
Decay
Death executioner caspase related to Apopain/Yama
caspase-3, Caspase 3, Casp3, Cas3, CC3
(FlyBase, 2017-, Xu et al., 2009, Harvey et al., 2001, Rawlings and Barrett, 1996-)
Dredd
Death related ced-3/Nedd2-like caspase
EG:115C2.9, Dcp-2/Dredd, Dcp-2, Dcp2
(FlyBase, 2017-, Xu et al., 2009, Harvey et al., 2001, Rawlings and Barrett, 1996-)
Drice
Death related ICE-like caspase
Ice, caspase-3
(FlyBase, 2017-, Xu et al., 2009, Harvey et al., 2001, Rawlings and Barrett, 1996-)
Dronc
Death regulator Nedd2-like caspase
Nc, Nedd2-like caspase, caspase-9
(FlyBase, 2017-, Xu et al., 2009, Harvey et al., 2001, Rawlings and Barrett, 1996-)
Strica
Ser/Thr-rich caspase
dream, Strica/Dream, Dream/Strica
(FlyBase, 2017-, Xu et al., 2009, Harvey et al., 2001, Rawlings and Barrett, 1996-)
External Data
Equivalent Group(s)
Other resource(s)

[MEROPS Family C14](https://www.ebi.ac.uk/merops/cgi-bin/famsum?family=c14)

Synonyms and Secondary IDs
Synonym(s)
CASP
Cysteine-dependent aspartyl-specific protease
CASPASES
CASPASE
Secondary FlyBase ID(s)
References (5)