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General Information
Name
JOSEPHIN DEUBIQUITINASES
Species
D. melanogaster
Symbol
JOSD-DUB
FlyBase ID
FBgg0000117
Date last reviewed
2020-06-08
Number of members
1
Description
Description
The Josephin (or Machado-Joseph Disease (MJD) domain) sub-family of deubiquitinases are cysteine proteases and that catalyze the removal of ubiquitin from ubiquitin chains and ubiquitinated proteins. They belong to MEROPS family C86. (Adapted from PMID:19626045).
Notes on Group

Only one Josephin deubiquitinase gene has been found in D.mel.

Source Material
The JOSEPHIN DEUBIQUITINASES Gene Group has been compiled by FlyBase curators using the following publication(s): Badmos et al., 2021, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, and Rawlings and Barrett, 1996- .
Key Gene Ontology (GO) terms
Biological Process
Cellular Component
Enzymatic activity
Enzyme name (EC)
Ubiquitinyl hydrolase 1 (3.4.19.12)
Related Gene Groups
Members (1)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
External Data
Other resource(s)

[MEROPS Family C86](https://www.ebi.ac.uk/merops/cgi-bin/famsum?family=c86)

Synonyms and Secondary IDs
Synonym(s)
JOSD-DUB
Machado-Joseph Disease domain proteases
MJD domain DUBs
Machado-Joseph disease protein
MJD
JOSEPHIN DEUBIQUITINASES
JOSEPHIN DOMAIN-CONTAINING DEUBIQUITINASES
Secondary FlyBase ID(s)
References (7)