The RING (Really Interesting New Gene) finger domain co-ordinates two Zn2+ ions via conserved Cys and His residues. Most proteins which contain a RING finger are assumed to be ubiquitin (E3) ligases. The RING finger binds ubiquitin-conjugating enzymes (E2) and promotes direct transfer of ubiquitin to the target protein. (Adapted from FBrf0215242 and PMID:19489725).
Du et al., 2011 (FBrf0225318) identified E3 RING domain-encoding genes based on InterPro domain (IPR001841) and Ying et al., 2011 (FBrf0215242) produced a computational survey of RING finger domains. Only genes that have supporting evidence for E3 activity based on direct experiment or phylogenetic/orthology-based prediction are included in the OTHER RING DOMAIN UBIQUITIN LIGASES gene group.