FB2020_06, released Dec 22, 2020

Gene Group : OTHER RING DOMAIN UBIQUITIN LIGASES

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General Information
Name
OTHER RING DOMAIN UBIQUITIN LIGASES
Species
D. melanogaster
Symbol
E3-RING-O
FlyBase ID
FBgg0000128
Date last reviewed
2019-11-05
Number of members
95
Description
Description

The RING (Really Interesting New Gene) finger domain co-ordinates two Zn2+ ions via conserved Cys and His residues. Most proteins which contain a RING finger are assumed to be ubiquitin (E3) ligases. The RING finger binds ubiquitin-conjugating enzymes (E2) and promotes direct transfer of ubiquitin to the target protein. (Adapted from FBrf0215242 and PMID:19489725).

Notes on Group

Du et al., 2011 (FBrf0225318) identified E3 RING domain-encoding genes based on InterPro domain (IPR001841) and Ying et al., 2011 (FBrf0215242) produced a computational survey of RING finger domains. Only genes that have supporting evidence for E3 activity based on direct experiment or phylogenetic/orthology-based prediction are included in the OTHER RING DOMAIN UBIQUITIN LIGASES gene group.

Source Material
The OTHER RING DOMAIN UBIQUITIN LIGASES Gene Group has been compiled by FlyBase curators using the following publication(s): Zavortink et al., 2020, Ji et al., 2014, Du et al., 2011, Ying et al., 2011, and Eisenhaber et al., 2007 .
Key Gene Ontology (GO) terms
Molecular Function
ubiquitin protein ligase activity
zinc ion binding
Biological Process
protein ubiquitination
Cellular Component
Related Gene Groups
Parent group(s)
RING DOMAIN E3 UBIQUITIN LIGASES
Members (95)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Bre1
Bre1
l(3)01640, dBre1
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
Cbl
Cbl proto-oncogene
D-cbl, dCbl, D-cblL, D-cblS, Cbl proto-oncogene ortholog
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG1317
(FlyBase, 2017-, Ying et al., 2011)
CG2617
38E.2
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG2681
EG:100G10.2
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG2991
(FlyBase, 2017-, Ying et al., 2011)
CG4080
(FlyBase, 2017-, Ying et al., 2011)
CG4325
EG:22E5.12
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG4813
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG5334
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG5347
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG5555
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG6752
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG6923
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG7376
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG7694
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG8141
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG8910
EG:EG0003.1
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG8974
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG9014
BG:DS08249.3
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG9855
(FlyBase, 2017-, Ying et al., 2011)
CG9941
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG10761
(FlyBase, 2017-, Ying et al., 2011)
CG10916
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG11360
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG11414
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG12099
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG12477
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG13344
anon-EST:GressD1
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG13442
(FlyBase, 2017-, Ying et al., 2011)
CG13481
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG13605
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG14435
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG14983
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG15141
(FlyBase, 2017-)
CG15814
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG16781
(FlyBase, 2017-, Ying et al., 2011)
CG17019
dRNF34
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG17329
BG:DS02740.5, DS02740.5
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG17717
(FlyBase, 2017-, Ying et al., 2011)
CG17991
(FlyBase, 2017-, Ying et al., 2011)
CG31807
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG32581
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG32847
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG32850
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG33552
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG34308
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
CG34375
(FlyBase, 2017-)
Cnot4
CCR4-NOT transcription complex subunit 4
NOT4
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
dgrn
degringolade
STUbL
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
dnr1
defense repressor 1
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
dor
deep orange
Vps18, EG:171E4.1, Dof, l(1)7
(FlyBase, 2017-)
dx
deltex
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
elgi
early girl
Nrdp1, dNrdp1
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
Fancl
Fancl
(FlyBase, 2017-)
Hakai
Hakai
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
hiw
highwire
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
Iru
Iruka
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
Kaz
Katazuke
(Zavortink et al., 2020, FlyBase, 2017-)
lmgA
lemming A
lmg, l(2)03424, lemming, APC11
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
Ltn1
Listerin E3 ubiquitin protein ligase 1
l(3)76BDr
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
mdlc
midlife crisis
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
mib1
mind bomb 1
D-mib, l(3)72CDa, Dmib, mib, Mindbomb
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
mib2
mind bomb 2
l(2)37Be, Be, D-mibl
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
Mkrn1
Makorin 1
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
msl-2
male-specific lethal 2
MSL2, MSL, kmA
(FlyBase, 2017-, Du et al., 2011)
Mul1
Mitochondrial E3 ubiquitin protein ligase 1
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
mura
murashka
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
mus302
mutagen-sensitive 302
mus(3)302
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
neur
neuralized
neu, Neuralised
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
nopo
no poles
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
Nse1
Non-SMC element 1
(FlyBase, 2017-, Ying et al., 2011)
Pex2
Peroxin 2
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
Pex10
Peroxin 10
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
Pex12
Peroxin 12
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
Pli
Pellino
(FlyBase, 2017-, Ji et al., 2014)
POSH
Plenty of SH3s
DPOSH, l(2)k15815
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
qin
qin
kumo
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
Rchy1
Ring finger and CHY zinc finger domain containing 1
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
Rnf146
Ring finger protein 146
Iduna
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
roq
roquin
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
Sce
Sex combs extra
dRING, dRING1, Ring, Sex comb extra, RING1
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
sina
seven in absentia
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
sinah
sina homologue
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
sip3
septin interacting protein 3
Hrd1
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
snama
something that sticks like glue
l(2)rQ313, BcDNA:LD21643, mnm, mini-me
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
snky
sneaky
ms(3)sneaky, ms(3)4, ms(3)snky, ms(3)ry4
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
Sou
Souji
(Zavortink et al., 2020, FlyBase, 2017-)
stc
shuttle craft
l(2)35Cb, l(2)br33, br33, BG:DS04929.4
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
Topors
Topoisomerase I-interacting protein
dTopors, nuclear blebber, nbl
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
Traf6
TNF-receptor-associated factor 6
dTRAF2, Traf2, dTraf6, EP325
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
Trc8
TRC8 ring finger protein
DTrc8
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
Ubr1
Ubr1 ubiquitin ligase
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
Ubr3
Ubr3 ubiquitin ligase
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
Vps11
Vacuolar protein sorting 11
(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
RING-containing domain ubiquitin-ligases
RING proteins
Really Interesting New Gene finger domain
E3 ligase
Ubiquitin ligase
E3
RING-E3
RING
OTHER RING DOMAIN UBIQUITIN LIGASES
RING FINGER DOMAIN PROTEINS
E3-RING-O
Secondary FlyBase ID(s)
References (7)