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General Information
Name
OTHER RING DOMAIN UBIQUITIN LIGASES
Species
D. melanogaster
Symbol
E3-RING-O
FlyBase ID
FBgg0000128
Date last reviewed
2019-11-05
Number of members
91
Description
Description

The RING (Really Interesting New Gene) finger domain co-ordinates two Zn2+ ions via conserved Cys and His residues. Most proteins which contain a RING finger are assumed to be ubiquitin (E3) ligases. The RING finger binds ubiquitin-conjugating enzymes (E2) and promotes direct transfer of ubiquitin to the target protein. (Adapted from FBrf0215242 and PMID:19489725).

Notes on Group

Du et al., 2011 (FBrf0225318) identified E3 RING domain-encoding genes based on InterPro domain (IPR001841) and Ying et al., 2011 (FBrf0215242) produced a computational survey of RING finger domains. Only genes that have supporting evidence for E3 activity based on direct experiment or phylogenetic/orthology-based prediction are included in the OTHER RING DOMAIN UBIQUITIN LIGASES gene group.

Source Material
The OTHER RING DOMAIN UBIQUITIN LIGASES Gene Group has been compiled by FlyBase curators using the following publication(s): Ji et al., 2014, Du et al., 2011, Ying et al., 2011, and Eisenhaber et al., 2007 .
Key Gene Ontology (GO) terms
Biological Process
Cellular Component
Related Gene Groups
Members (91)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Cbl proto-oncogene
D-cbl, dCbl, D-cblL, D-cblS, Dv-cbl
CCR4-NOT transcription complex subunit 4
NOT4
lemming A
lmg, lemming, l(2)03424, APC11
Listerin E3 ubiquitin protein ligase 1
l(3)76BDr
mind bomb 1
D-mib, l(3)72CDa, mib, l(3)72Db, Dmib
mind bomb 2
l(2)37Be, Be, D-mibl
male-specific lethal 2
MSL2, MSL, kmA
Mitochondrial E3 ubiquitin protein ligase 1
Plenty of SH3s
DPOSH, l(2)k15815
Ring finger and CHY zinc finger domain containing 1
Sex combs extra
dRING, dRING1, Ring, Sex comb extra, RING1
septin interacting protein 3
Hrd1
something that sticks like glue
l(2)rQ313, BcDNA:LD21643, mnm, mini-me
sneaky
ms(3)sneaky, ms(3)4, ms(3)snky, ms(3)ry4
shuttle craft
l(2)35Cb, l(2)br33, br33, BG:DS04929.4
Topoisomerase I-interacting protein
dTopors, nbl, nuclear blebber
TNF-receptor-associated factor 6
dTRAF2, Traf2, dTRAF6, EP325
TRC8 ring finger protein
DTrc8
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
RING-containing domain ubiquitin-ligases
RING proteins
Really Interesting New Gene finger domain
E3 ligase
Ubiquitin ligase
E3
RING-E3
RING
OTHER RING DOMAIN UBIQUITIN LIGASES
RING FINGER DOMAIN PROTEINS
E3-RING-O
Secondary FlyBase ID(s)
References (6)