Gene Group: OTHER RING DOMAIN UBIQUITIN LIGASES

General Information

Name

OTHER RING DOMAIN UBIQUITIN LIGASES

Species

D. melanogaster

Symbol

RING

FlyBase ID

FBgg0000128

Date last reviewed

2019-11-05

Number of members

Description

The RING (Really Interesting New Gene) finger domain co-ordinates two Zn²⁺ ions via conserved Cys and His residues. Most proteins which contain a RING finger are assumed to be ubiquitin (E3) ligases. The RING finger binds ubiquitin-conjugating enzymes (E2) and promotes direct transfer of ubiquitin to the target protein. (Adapted from FBrf0215242 and PMID:19489725).

Notes on Group

Du et al., 2011 (FBrf0225318) identified E3 RING domain-encoding genes based on InterPro domain (IPR001841) and Ying et al., 2011 (FBrf0215242) produced a computational survey of RING finger domains. Only genes that have supporting evidence for E3 activity based on direct experiment or phylogenetic/orthology-based prediction are included in the OTHER RING DOMAIN UBIQUITIN LIGASES gene group.

Source Material

The OTHER RING DOMAIN UBIQUITIN LIGASES Gene Group has been compiled by FlyBase curators using the following publication(s): Ji et al., 2014, Du et al., 2011, Ying et al., 2011, and Eisenhaber et al., 2007.

Key Gene Ontology (GO) terms

Molecular Function

ubiquitin protein ligase activity

zinc ion binding

Biological Process

protein ubiquitination

Cellular Component

Related Gene Groups

Parent group(s)

RING DOMAIN E3 UBIQUITIN LIGASES

Members (91)

For all members:

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Bre1

l(3)01640, dBre1

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Cbl

Cbl proto-oncogene

D-cbl, dCbl, D-cblL, D-cblS, cable

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG1317

(FlyBase, 2017-, Ying et al., 2011)

CG2617

38E.2

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG2681

EG:100G10.2

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG2991

(FlyBase, 2017-, Ying et al., 2011)

CG4080

(FlyBase, 2017-, Ying et al., 2011)

CG4325

EG:22E5.12

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG4813

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG5334

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG5347

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG5555

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG6752

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG6923

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG7376

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG7694

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG8141

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG8910

EG:EG0003.1

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG8974

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG9014

BG:DS08249.3

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG9855

(FlyBase, 2017-, Ying et al., 2011)

CG9941

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG10761

(FlyBase, 2017-, Ying et al., 2011)

CG10916

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG11360

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG11414

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG12099

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG12477

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG13025

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG13344

anon-EST:GressD1

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG13442

(FlyBase, 2017-, Ying et al., 2011)

CG13481

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG13605

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG14435

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG14983

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG15141

(FlyBase, 2017-)

CG15814

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG16781

(FlyBase, 2017-, Ying et al., 2011)

CG17019

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG17329

BG:DS02740.5, DS02740.5

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG17717

(FlyBase, 2017-, Ying et al., 2011)

CG17991

(FlyBase, 2017-, Ying et al., 2011)

CG31807

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG32581

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG32847

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG32850

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG33552

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG34308

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Cnot4

CCR4-NOT transcription complex subunit 4

NOT4

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

dgrn

degringolade

STUbL

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

dnr1

defense repressor 1

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

deltex

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

elgi

early girl

Nrdp1, dNrdp1

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Fancl

(FlyBase, 2017-)

Hakai

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

hiw

highwire

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Iru

Iruka

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

lmgA

lemming A

lmg, l(2)03424, lemming, APC11

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Ltn1

Listerin E3 ubiquitin protein ligase 1

l(3)76BDr

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

mdlc

midlife crisis

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

mib1

mind bomb 1

D-mib, l(3)72CDa, Dmib, l(3)72Db, mind-bomb

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

mib2

mind bomb 2

l(2)37Be, Be, D-mibl

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Mkrn1

Makorin 1

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

msl-2

male-specific lethal 2

MSL2, MSL, kmA

(FlyBase, 2017-, Du et al., 2011)

Mul1

Mitochondrial E3 ubiquitin protein ligase 1

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

mura

murashka

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

neur

neuralized

neu, Neuralised

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

nopo

no poles

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Nse1

Non-SMC element 1

(FlyBase, 2017-, Ying et al., 2011)

Pex2

Peroxin 2

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Pex10

Peroxin 10

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Pex12

Peroxin 12

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Pli

Pellino

(FlyBase, 2017-, Ji et al., 2014)

POSH

Plenty of SH3s

DPOSH, l(2)k15815

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

qin

kumo

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Rchy1

Ring finger and CHY zinc finger domain containing 1

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Rnf146

Ring finger protein 146

Iduna

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

roq

roquin

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Sce

Sex combs extra

dRING, dRING1, Ring, Sex comb extra, RING1

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

sina

seven in absentia

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

sinah

sina homologue

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

sip3

septin interacting protein 3

Hrd1

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

snama

something that sticks like glue

l(2)rQ313, BcDNA:LD21643, mnm, mini-me

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

snky

sneaky

ms(3)ry4, ms(3)snky, ms(3)4, ms(3)sneaky

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

stc

shuttle craft

l(2)35Cb, l(2)br33, br33, BG:DS04929.4

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Topors

Topoisomerase I-interacting protein

dTopors, nuclear blebber, nbl

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Traf6

TNF-receptor-associated factor 6

dTRAF2, Traf2, dTRAF6, EP325

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Trc8

TRC8 ring finger protein

DTrc8

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Ubr1

Ubr1 ubiquitin ligase

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Ubr3

Ubr3 ubiquitin ligase

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Vps11

Vacuolar protein sorting 11

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

External Data

Equivalent Group(s)

Other resource(s)

Synonyms and Secondary IDs

Synonym(s)

RING

RING-containing domain ubiquitin-ligases

RING proteins

Really Interesting New Gene finger domain

E3 ligase

Ubiquitin ligase

RING-E3

OTHER RING DOMAIN UBIQUITIN LIGASES

RING FINGER DOMAIN PROTEINS

Secondary FlyBase ID(s)

References (6)

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