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General Information
Name
OTHER RING DOMAIN UBIQUITIN LIGASES
Species
D. melanogaster
Symbol
RING
FlyBase ID
FBgg0000128
Date last reviewed
2017-01-16
Number of members
119
Description
Description
The RING (Really Interesting New Gene) finger domain co-ordinates two Zn2+ ions via conserved Cys and His residues. Most proteins which contain a RING finger are assumed to be ubiquitin (E3) ligases. The RING finger binds ubiquitin-conjugating enzymes (E2) and promotes direct transfer of ubiquitin to the target protein. (Adapted from FBrf0215242 and PMID:19489725).
Notes on Group
Du et al, 2011 (FBrf0225318) identified 133 E3 RING domain-encoding genes using an InterPro domain (IPR001841) search. 7 of these genes (Phf7, CG11534, Plekhm1, CG32486, rols, NSD and CG42726) have been excluded from this list as (i) unable to verify whether they contain true RING finger domains or just related Zn-finger domains; and (ii) they are absent from the survey of RING finger domains by Ying et al, 2011 (FBrf0215242).
Source Material
The OTHER RING DOMAIN UBIQUITIN LIGASES Gene Group has been compiled by FlyBase curators using the following publication(s): Ji et al., 2014, Du et al., 2011, Ying et al., 2011, Eisenhaber et al., 2007, FBrf0224297, and FBrf0225003.
Key Gene Ontology (GO) terms
Biological Process
Cellular Component
Related Gene Groups
Members (119)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Cbl proto-oncogene
D-cbl, dCbl, D-cblL, D-cblS, cable
CCR4-NOT transcription complex subunit 4
NOT4
deep orange
Vps18, EG:171E4.1, Dof, l(1)7
lethal (3) 73Ah
l(3)02540
lemming A
lmg, l(2)03424, lemming, APC11
Lost PHDs of trr
cmi, cara mitad
light
Vps41, l(2)40Fb
Listerin E3 ubiquitin protein ligase 1
l(3)76BDr
Mi-2
dMi-2, Pha, dMi2, l(3)A154.3M3, PHD-containing ATPase
mind bomb 1
D-mib, l(3)72CDa, Dmib, l(3)72Db, mind-bomb
mind bomb 2
l(2)37Be, Be, D-mibl
male-specific lethal 2
MSL2, MSL, kmA
Mitochondrial E3 ubiquitin protein ligase 1
Plenty of SH3s
DPOSH, l(2)k15815
Posterior sex combs
Posterior sex comb, l(2)49Ea
Ring finger and CHY zinc finger domain containing 1
Sex combs extra
dRING, dRING1, Ring, Sex comb extra, RING1
septin interacting protein 3
Hrd1
something that sticks like glue
l(2)rQ313, BcDNA:LD21643, mnm, mini-me
sneaky
ms(3)ry4, ms(3)snky, ms(3)4, ms(3)sneaky
shuttle craft
l(2)35Cb, l(2)br33, br33, BG:DS04929.4
Suppressor of zeste 2
Suppressor 2 of zeste, Su(z)2D, Arp, Su(z)3, Suppressor of zeste two
Topoisomerase I-interacting protein
dTopors, nuclear blebber, nbl
TNF-receptor-associated factor 6
dTRAF2, Traf2, dTRAF6, EP325
TRC8 ring finger protein
DTrc8
trithorax
l(3)j14A6, trxG, DMTRXIII, Rg-bx, l(3)s5452
Vacuolar protein sorting 8
External Data
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
RING
RING-containing domain ubiquitin-ligases
RING proteins
Really Interesting New Gene finger domain
E3 ligase
Ubiquitin ligase
E3
RING-E3
OTHER RING DOMAIN UBIQUITIN LIGASES
RING FINGER DOMAIN PROTEINS
Secondary FlyBase ID(s)
References (8)