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General Information
Name
CULLINS
Species
D. melanogaster
Symbol
CUL
FlyBase ID
FBgg0000131
Date last reviewed
2014-02-27
Number of members
6
Description
Description

Cullins are an evolutionarily conserved, structurally-related gene family, with an N-terminal bearing cullin repeats followed by a cullin homology domain and a neddylation site. Cullins act as scaffolds to assemble multi-subunit Cullin-RING E3 ubiquitin ligase (CRL) complexes. A CRL complex is characterised by a cullin-RING-type E3 ubiquitin ligase interaction, which acts as the catalytic core and recruits the E2 ubiquitin-conjugating enzyme, and a cullin-adaptor protein-substrate recognition protein interaction which links the E3 ligase to its target for ubiquitination. (Adapted from FBrf0224296).

Notes on Group
Source Material
The CULLINS Gene Group has been compiled by FlyBase curators using the following publication(s): Roberts et al., 2012, Ayyub, 2011, Du et al., 2011, and Sarikas et al., 2011 .
Key Gene Ontology (GO) terms
Biological Process
Related Gene Groups
Members (6)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Cullin 1
lin19, Cul-1, dCul1, l(2)k01207, l(2)02074
Cullin 3
gft, Cul-3, guftagu, l(2)br34, l(2)35Cd
External Data
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
CUL
CULLINS
Cullin
Secondary FlyBase ID(s)
References (5)