FB2025_01 , released February 20, 2025
Complex: NUCLEAR PORE COMPLEX
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General Information
Name
NUCLEAR PORE COMPLEX
Species
D. melanogaster
Symbol
NPC
FlyBase ID
FBgg0000146
Date last reviewed
2023-08-08
Number of members
29
Description
Description
The Nuclear Pore Complex (NPC) is a large protein complex embedded in the nuclear membrane that facilitates nucleocytoplasmic traffic. The NPC is composed of approximately 30 different proteins: the nucleoporins. The NPC displays 8-fold symmetry and each nucleoporin is present in multiple copies. From the central ring that forms the pore, filaments protrude into the cytoplasm (cytoplasmic filaments) and the nucleoplasm (nuclear basket). Many nucleoporins contain FG repeats which are thought to act as a diffusion barrier and docking sight for transport receptors (karyopherins). Export and import is controlled by the interaction of the karyopherins with localization and export sequences. (Adapted from FBrf0220062 and PMID:21495847).
Notes on Group

xmas-2, drongo and RanBP3 listed in FBrf0219251 have not been included in the NUCLEAR PORE COMPLEX gene group. It seems likely that xmas-2 it associates with the NPC rather than being part of the complex (PMID:12411502). drongo contains FG repeats but is not a known NPC protein. RanBP3 is a cofactor for nuclear export.

Source Material
The NUCLEAR PORE COMPLEX Gene Group has been compiled using the following publication(s): Neumann et al., 2010, Sabri et al., 2007, and Lau et al., 2006 .
Key Gene Ontology (GO) terms
Molecular Function
structural constituent of nuclear pore
Biological Process
nucleocytoplasmic transport
Cellular Component
nuclear pore
Related Gene Groups
Other related group(s)
IMPORTINS
Members (29)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Aladin
Aladin
(Neumann et al., 2010, Sabri et al., 2007)
Gle1
Gle1 RNA export mediator
(Neumann et al., 2010, Sabri et al., 2007)
Gp210
Glycoprotein 210 kDa
(Neumann et al., 2010, Sabri et al., 2007)
mbo
members only
Nup88, l(3)05043, DNup88, l(3)S146507
(Neumann et al., 2010, Sabri et al., 2007)
Mgtor
Megator
Mtor, Bx34, Tpr, l(2)k03905
(Neumann et al., 2010, Sabri et al., 2007)
Ndc1
Nuclear division cycle 1
(Neumann et al., 2010, Lau et al., 2006)
Nup35
Nucleoporin 35kDa
(Neumann et al., 2010, Sabri et al., 2007)
Nup37
Nucleoporin 37kD
(Neumann et al., 2010, Sabri et al., 2007)
Nup43
Nucleoporin 43kD
(Neumann et al., 2010)
Nup44A
Nucleoporin at 44A
seh1
(Neumann et al., 2010, Sabri et al., 2007)
Nup50
Nucleoporin 50kD
Nucleoporin 50
(Neumann et al., 2010, Sabri et al., 2007)
Nup54
Nucleoporin 54kD
(Neumann et al., 2010, Sabri et al., 2007)
Nup58
Nucleoporin 58kD
(Neumann et al., 2010, Sabri et al., 2007)
Nup62
Nucleoporin 62kD
p62, Nucleoporin
(Neumann et al., 2010, Sabri et al., 2007)
Nup75
Nucleoporin 75kD
(Neumann et al., 2010, Sabri et al., 2007)
Nup93-1
Nucleoporin 93kD-1
Nup93, BcDNA:LD21129
(Sabri et al., 2007)
Nup93-2
Nucleoporin 93kD-2
Nup93
(Neumann et al., 2010)
Nup98-96
Nucleoporin 98-96kD
Nup98, Nup96, l(3)95BCd, Nucleoporin 98
(Neumann et al., 2010, Sabri et al., 2007)
Nup107
Nucleoporin 107kD
Nup170, BcDNA:LD18761, Nup
(Neumann et al., 2010, Sabri et al., 2007)
Nup133
Nucleoporin 133kD
(Neumann et al., 2010, Sabri et al., 2007)
Nup153
Nucleoporin 153kD
(Neumann et al., 2010, Sabri et al., 2007)
Nup154
Nucleoporin 154kD
zk, nup32D, tulipano, tlp, zonder kloten
(Neumann et al., 2010, Sabri et al., 2007)
Nup160
Nucleoporin 160kD
Nucleoporin 160, l(2)SH2055
(Neumann et al., 2010, Sabri et al., 2007)
Nup188
Nucleoporin 188kDa
(Neumann et al., 2010, Sabri et al., 2007)
Nup205
Nucleoporin 205kD
(Neumann et al., 2010, Sabri et al., 2007)
Nup214
Nucleoporin 214kD
l(2)10444, DNup214, CAN
(Neumann et al., 2010, Sabri et al., 2007)
Nup358
Nucleoporin 358kD
RanBP2
(Neumann et al., 2010, Sabri et al., 2007)
Rae1
Rae1
(Neumann et al., 2010)
Sec13
Secretory 13
l(3)01031
(Neumann et al., 2010, Sabri et al., 2007)
External Data
Synonyms and Secondary IDs
Synonym(s)
NPC
NUCLEAR PORE COMPLEX
Nucleoporins
Nup
Secondary FlyBase ID(s)
References (4)