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General Information
Name
JAMM DEUBIQUITINASES
Species
D. melanogaster
Symbol
JAMM-DUB
FlyBase ID
FBgg0000160
Date last reviewed
2020-06-08
Number of members
6
Description
Description
The JAMM (JAB1/MPN/MOV34) sub-family of deubiquitinases are Zn[2+]-binding metalloproteases. In general, JAMMs are components of larger assemblies such as the proteasome. JAMM deubiquitinases belong to MEROPS family M67. (Adapted from FBrf0224141).
Notes on Group

Although classified as JAMM deubiquitinases in some publications, CSN6, Rpn8 and Prp8 (and their human orthologs - see PMID:17559875) lack the ability to co-ordinate Zn[2+] and are predicted to be enzymatically inactive - within MEROPS, these proteins are classed as non-peptidase homologs of the M67 family, or are not listed (http://merops.sanger.ac.uk/). All these genes are omitted from this gene group and are instead listed in the 'M67 NON-PEPTIDASE HOMOLOGS' gene group. eIF3f1, eIF3f2 and eIF3h are also classified as 'M67 non-peptidase homologs' in MEROPS, but they are included here because there is evidence that the human orthologs (EIF3F and EIF3H) exhibit deubiquitinase activity (PMID:21124883 and PMID:32269044). CSN5 has also been classed as a JAMM deubiquitinase in the literature, though it is now recognized as a deneddylase - it is included in the 'METALLO-TYPE DENEDDYLASES' gene group.

Source Material
The JAMM DEUBIQUITINASES Gene Group has been compiled by FlyBase curators using the following publication(s): Badmos et al., 2021, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, and Rawlings and Barrett, 1996- .
Key Gene Ontology (GO) terms
Biological Process
Cellular Component
Related Gene Groups
Protein Complex group(s)
Members (6)
For all members:
External Data
Equivalent Group(s)
Other resource(s)

[MEROPS Family M67](https://www.ebi.ac.uk/merops/cgi-bin/famsum?family=m67)

Synonyms and Secondary IDs
Synonym(s)
JAMM-DUB
JAMM family
JAB1/MPN/MOV34 family
JAMM domain proteases
JAMM/MPN+ family
JAMM
JAMM DOMAIN-CONTAINING PROTEASES (DEUBIQUITINASES)
JAMM DEUBIQUITINASES
Secondary FlyBase ID(s)
References (7)