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General Information
Name
UBIQUITIN SPECIFIC PROTEASES (DEUBIQUITINASES)
Species
D. melanogaster
Symbol
USP-DUB
FlyBase ID
FBgg0000170
Date last reviewed
2015-08-25
Number of members
23
Description
Description
The Ubiquitin Specific Proteases (USP) is the largest sub-family of deubiquitinases. They are cysteine proteases and catalyze the removal of ubiquitin from ubiquitin chains and ubiquitinated proteins. (Adapted from PMID:19626045).
Notes on Group
In the human ortholog of PAN2, USP52, the catalytic cysteine has been replaced by alanine (PMID:14715245). It is classed as a non-peptidase homolog in MEROPS (http://merops.sanger.ac.uk/). Alignment of the D.mel PAN2 with human USP52 indicates that the catalytic cysteine has been replaced by serine.
Source Material
The UBIQUITIN SPECIFIC PROTEASES (DEUBIQUITINASES) Gene Group has been compiled by FlyBase curators using the following publication(s): Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, and Zhang et al., 2012.
Key Gene Ontology (GO) terms
Biological Process
Cellular Component
Related Gene Groups
Parent group(s)
Members (23)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Poly(A)-binding protein-dependent poly(A) ribonuclease 2
scrawny
Usp36, dUSP36, mule, ubiquitin-specific protease 36, l(3)02331
Ubiquitin specific protease 47
Ubp64E, Ubp64, E(var)3-64E, D-UBP-64E
External Data
Synonyms and Secondary IDs
Synonym(s)
USP-DUB
Ubiquitin-specific peptidases
USP
UBIQUITIN SPECIFIC PROTEASES (DEUBIQUITINASES)
UBIQUITIN SPECIFIC PROTEASES (DEUBIQUITINASES)
Secondary FlyBase ID(s)
References (6)