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General Information
Name
USP DEUBIQUITINASES
Species
D. melanogaster
Symbol
USP-DUB
FlyBase ID
FBgg0000170
Date last reviewed
2020-06-08
Number of members
20
Description
Description
The Ubiquitin Specific Proteases (USP) is the largest sub-family of deubiquitinases. They are cysteine proteases and catalyze the removal of ubiquitin from ubiquitin chains and ubiquitinated proteins. USP deubiquitinases belong to MEROPS family C19. (Adapted from PMID:19626045).
Notes on Group

Although included in lists of deubiquitinases in several publications, ec, PAN2 and Usp39 lack key catalytic residues and are classed as non-peptidase homologs of the C19 family in MEROPS (http://merops.sanger.ac.uk/). Moreover, all isoforms of ec and the human ortholog of Usp39 have been shown experimentally to lack deubiquitinase activity (FBrf0200872 and PMID:18728397, respectively). Thus, all three genes are omitted from this gene group and are instead listed in the 'C19 NON-PEPTIDASE HOMOLOGS' gene group.

Source Material
The USP DEUBIQUITINASES Gene Group has been compiled by FlyBase curators using the following publication(s): Badmos et al., 2021, Engel et al., 2014, Clague et al., 2013, Tsou et al., 2012, Zhang et al., 2012, and Rawlings and Barrett, 1996- .
Key Gene Ontology (GO) terms
Biological Process
Cellular Component
Enzymatic activity
Enzyme name (EC)
Ubiquitinyl hydrolase 1 (3.4.19.12)
Related Gene Groups
Members (20)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
External Data
Other resource(s)

[MEROPS Family C19](https://www.ebi.ac.uk/merops/cgi-bin/famsum?family=c19)

Synonyms and Secondary IDs
Synonym(s)
USP-DUB
Ubiquitin-specific peptidases
USP
UBIQUITIN SPECIFIC PROTEASES (DEUBIQUITINASES)
UBIQUITIN SPECIFIC PROTEASES (DEUBIQUITINASES)
USP DEUBIQUITINASES
Secondary FlyBase ID(s)
References (8)