Gene Group: NEUROPEPTIDES

General Information

Name

NEUROPEPTIDES

Species

D. melanogaster

Symbol

NPPH

FlyBase ID

FBgg0000179

Date last reviewed

2015-08-24

Number of members

Description

Neuropeptides are secreted into the extracellular space where they interact with cell surface receptors (usually G protein coupled receptors). They are extremely diverse, acting as neurotransmitters, neuromodulators, hormones or growth factors. (Adapted from FBrf0211443 and PMID:27813667).

Notes on Group

Source Material

The NEUROPEPTIDES Gene Group has been compiled by FlyBase curators using the following publication(s): Mele and Johnson, 2019, Jung et al., 2014, Veenstra and Ida, 2014, Andersen et al., 2012, Ida et al., 2011, Nässel and Winther, 2010, Veenstra, 2009, Wegener and Gorbashov, 2008, and Nassel, 2002 .

Key Gene Ontology (GO) terms

Molecular Function

neuropeptide hormone activity

hormone activity

signaling receptor binding

Biological Process

cell surface receptor signaling pathway

Cellular Component

extracellular space

Related Gene Groups

Parent group(s)

RECEPTOR LIGANDS

Other related group(s)

CLASS A GPCR NEUROPEPTIDE AND PROTEIN HORMONE RECEPTORS

CLASS B GPCRs, SUBFAMILY B1

INSULIN-LIKE PEPTIDES

Members (49)

For all members:

GO ribbon stack

	molecular function	biological process	cellular component

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Akh

Adipokinetic hormone

Drm-AKH, dAkh

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

amn

amnesiac

PACAP38, Drm-amn, PACAP, cheapdate

(Nässel and Winther, 2010, Nassel, 2002)

AstA

Allatostatin A

Ast, drostatin-A4, Ast-A, AstA-1, allatostatin

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

AstC

Allatostatin C

Ast-C, drostatin-C, flatline, Ast2, FLT

(Nässel and Winther, 2010, Veenstra, 2009, Wegener and Gorbashov, 2008, Nassel, 2002)

AstCC

Allatostatin double C

Ast-CC

(Veenstra, 2009)

Burs

Bursicon

bursicon α, bursα, burs α, bursicon α-subunit

(Nässel and Winther, 2010)

Capa

Capability

capa-1, CAP_2b, capa-2, capa-3, Drm-PK-1

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

CCAP

Crustacean cardioactive peptide

Cardioacceleratory peptide

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

CCHa1

CCHamide-1

(Veenstra and Ida, 2014, Nässel and Winther, 2010)

CCHa2

CCHamide-2

(Veenstra and Ida, 2014, Nässel and Winther, 2010)

CNMa

CNMamide

(Jung et al., 2014)

Crz

Corazonin

Drm-COR, Dm-Crz, COR

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

Dh31

Diuretic hormone 31

diuretic hormone, Drm-DH₃₁

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

Dh44

Diuretic hormone 44

Dh, DH₄₄, Diuretic hormone, CRF-like peptide, Drm-DH

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

Dsk

Drosulfakinin

sulfakinin, Drm-SK-2, DSK-2, DSK-1, DSK I

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

Eclosion hormone

DMEHAB, Drm-EH

(Nässel and Winther, 2010, Nassel, 2002)

ETH

Ecdysis triggering hormone

Drm-ETH-2, Drm-ETH-1, ETH1, ETH2, ecdysis triggering hormone-2

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

FMRFa

FMRFamide

Fmrf, dFMRFa, dFMRFamide, FMRFamide-related, DPKQDFMRFamide

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

Gpa2

Glycoprotein hormone alpha 2

(Nässel and Winther, 2010)

Gpb5

Glycoprotein hormone beta 5

β-glycoprotein-hormone-related

(Nässel and Winther, 2010)

Hug

Hugin

Drm-PK-2, pyrokinin-2, hug-γ, hug γ, hugγ

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

Ilp1

Insulin-like peptide 1

dilp1, DILP, insulin-like peptide, dilp-1, Dilp 1

(Nässel and Winther, 2010, Nassel, 2002)

Ilp2

Insulin-like peptide 2

dilp2, Dilp 2, DILP, dilp-2, Ilp-2

(Nässel and Winther, 2010, Nassel, 2002)

Ilp3

Insulin-like peptide 3

dilp3, DILP-3, Dilp 3, Ilp, DILPs

(Nässel and Winther, 2010, Nassel, 2002)

Ilp4

Insulin-like peptide 4

dilp4, mes3, DILPs, dilp-4, Dilp

(Nässel and Winther, 2010, Nassel, 2002)

Ilp5

Insulin-like peptide 5

dilp5, DILP, Dilp 5, dilp-5, DILPs

(Nässel and Winther, 2010)

Ilp6

Insulin-like peptide 6

dilp6, dilp-6, DILP, Dilp 6, DILPs

(Nässel and Winther, 2010, Nassel, 2002)

Ilp7

Insulin-like peptide 7

dilp7, DILP, DILP 7, DILPs, dilp-7

(Nässel and Winther, 2010, Nassel, 2002)

Ilp8

Insulin-like peptide 8

dilp8, Drosophila insulin-like peptide 8, DILPs, DILP 8

(Andersen et al., 2012)

ITP

Ion transport peptide

DrmITP, DrmITPL1, DrmITPL2

(Nässel and Winther, 2010, Nassel, 2002)

Leucokinin

DLK, drosokinin, Kinin, pp, LCK

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

Mip

Myoinhibiting peptide precursor

drostatin-B2, AstB, Allatostatin B, AstB-1, myoinhibitory peptide

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

Myosuppressin

DMS, Dromyosuppressin, Drm-MS, Nems, TDVDHVFLRFamide

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

NPF

neuropeptide F

dNPF, Drm-NPF, Dm-NPF

(Veenstra and Ida, 2014, Ida et al., 2011, Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

Nplp1

Neuropeptide-like precursor 1

IPNamide, IPNa, APK, Neuropeptide like precursor protein 1, MTYa

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008)

Nplp2

Neuropeptide-like precursor 2

(Nässel and Winther, 2010)

Nplp3

Neuropeptide-like precursor 3

(Nässel and Winther, 2010)

Nplp4

Neuropeptide-like precursor 4

(Nässel and Winther, 2010)

Orcokinin

OK-B

(Veenstra and Ida, 2014)

Pburs

Partner of Bursicon

bursicon β, pu, bursβ, burs β, bursicon

(Nässel and Winther, 2010)

Pdf

Pigment-dispersing factor

PDH, PAP, Drm-PDF, cPDH, pigment dispersing hormone

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

Proc

Proctolin

Proct

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

Ptth

Prothoracicotropic hormone

(Mele and Johnson, 2019, Nässel and Winther, 2010)

RYa

RYamide

(Ida et al., 2011)

SIFa

SIFamide

IFa, Neb-LFamide, Drm-IFa

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

sNPF

short neuropeptide F precursor

short neuropeptide F, short NPF, Drm-sNPF-1, Drm-sNPF-4, sNPF-2

(Ida et al., 2011, Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

Sex Peptide

Acp70A, ACP, DrmSP, Accessory gland protein 70A

(Nässel and Winther, 2010)

spab

space blanket

(Nässel and Winther, 2010)

Tachykinin

DTK, tachykinin-3, DTK-5, DTK-4, DTK-6

(Veenstra and Ida, 2014, Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

External Data

Equivalent Group(s)

Human Neuropeptides (HGNC)

Nematode Insulin-Related Genes (WormBase)

Nematode Neuropeptide-Like Proteins (WormBase)

Other resource(s)

Synonyms and Secondary IDs

Synonym(s)

NPPH

Extracellular ligands

Hormones

Secreted ligands

NEUROPEPTIDES

NEUROPEPTIDES, PEPTIDE AND PROTEIN HORMONES

Secondary FlyBase ID(s)

References (10)

Report Sections

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