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General Information
Name
KINESINS
Species
D. melanogaster
Symbol
KIF
FlyBase ID
FBgg0000190
Date last reviewed
2015-09-28
Number of members
26
Description
Description

Kinesin superfamily proteins (KIFs) are microtubule motor proteins which use the hydrolysis of ATP to drive directional movement along microtubules. KIFs possess a well-conserved 360 residue globular head domain which binds and hydrolyses ATP and interacts with microtubules. Many KIFs homodimerize via coiled-coil interactions in the stalk region. KIFs bind cargo through their variable tail regions and are involved in transporting organelles, protein complexes, mRNAs and the movement of spindles and chromosomes during cell division. (Adapted from FBrf0219884).

Notes on Group

The KINESIN gene group contains kinesins and kinesin-like proteins belonging to the kinesin superfamily. These are also referred to as kinesin heavy chains/motor subunits and do not include kinesin light chains. The PDF document associated with FBrf0220063 contains the most up-to-date list of KIF family members.

The product of CG14535 may not have microtubule motor activity because a mouse ortholog, Kif26a, has been characterized as an unconventional/atypical kinesin lacking ATPase activity (PMID:19914172).

Source Material
Key Gene Ontology (GO) terms
Biological Process
Cellular Component
Related Gene Groups
Parent group(s)
Members (26)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
External Data
Synonyms and Secondary IDs
Synonym(s)
KIF
KINESINS
Kinesin-like proteins
Kinesin heavy chain
Kinesin motor subunits
KLP
KHC
Secondary FlyBase ID(s)
References (10)