Kinesin superfamily proteins (KIFs) are microtubule motor proteins which use the hydrolysis of ATP to drive directional movement along microtubules. KIFs possess a well-conserved 360 residue globular head domain which binds and hydrolyses ATP and interacts with microtubules. Many KIFs homodimerize via coiled-coil interactions in the stalk region. KIFs bind cargo through their variable tail regions and are involved in transporting organelles, protein complexes, mRNAs and the movement of spindles and chromosomes during cell division. (Adapted from FBrf0219884).
The KINESIN gene group contains kinesins and kinesin-like proteins belonging to the kinesin superfamily. These are also referred to as kinesin heavy chains/motor subunits and do not include kinesin light chains. The PDF document associated with FBrf0220063 contains the most up-to-date list of KIF family members.