The majority of neuropeptide/protein hormone GPCR belong to the Class A family of GPCRs. The secreted ligands for this subfamily include neuropeptides, peptide hormones and protein hormones. (Adapted from FBrf0195077).
The CLASS A GPCR NEUROPEPTIDE AND PROTEIN HORMONE RECEPTORS gene group contains neuropeptide and protein hormone-activated Class A GPCRs for which endogenous ligands have been identified and orphan receptors.