STE11 MAP kinase kinase kinases (MAPKKKs) belong to the STE11 subfamily and are serine/threonine kinases that phosphorylate MAP kinase kinases in MAPK signalling cascades. MAPKKKs are activated by MAP kinase kinase kinase kinases (MAP4Ks). (Adapted from FBrf0225276.)
Notes on Group
Other MAPKKKs are found in the NON-RECEPTOR TLK KINASES and GERMINAL CENTER KINASES groups.