Gene Group: RECEPTOR TYROSINE KINASES

General Information

Name

RECEPTOR TYROSINE KINASES

Species

D. melanogaster

Symbol

RTK

FlyBase ID

FBgg0000220

Date last reviewed

2022-11-01

Number of members

Description

Receptor tyrosine kinases (RTK) are single-pass transmembrane receptors expressed on the plasma membrane. Upon the binding of an extracellular signalling molecule (e.g. growth factors, hormones), RTKs dimerize leading to the activation of the intracellular tyrosine kinase domain and intermolecular phosphorylation. The phosphotyrosines function as specific sites for the assembly, phosphorylation and activation of downstream signaling molecules. (Adapted from PMID:20602996).

Notes on Group

Wsck is predicted to be a pseudokinase based on sequence analysis in FBrf0209106.

In other metazoans, otk orthologous kinases are inactive. otk deviates in some consensus kinase motifs, indicating that it may be a pseudokinase. However, FBrf0055961 have shown a kinase activity associated with immunoprecipitated otk.

drl, Drl-2 and dnt are members of the catalytically inactive Receptor related to tyrosine kinases (RYK) subfamily (FBrf0222811, FBrf0132248) and are therefore omitted from this group.

Source Material

The RECEPTOR TYROSINE KINASES Gene Group has been compiled using the following publication(s): Mele and Johnson, 2019, Sopko et al., 2014, Petrova et al., 2013, Sopko and Perrimon, 2013, Vogel et al., 2013, Manning et al., 2002, Halford and Stacker, 2001, and Morrison et al., 2000 .

Key Gene Ontology (GO) terms

Molecular Function

transmembrane receptor protein tyrosine kinase activity

Biological Process

protein phosphorylation

Cellular Component

plasma membrane

Enzymatic activity

Enzyme name (EC)

receptor protein-tyrosine kinase (2.7.10.1)

Related Gene Groups

Parent group(s)