Wsck is predicted to be a pseudokinase based on sequence analysis in FBrf0209106.
drl, Drl-2 and dnt are members of the Receptor related to tyrosine kinases (RYK) subfamily. Members of this family are catalytically inactive (pseudokinases) (FBrf0222811, FBrf0132248).
In other metazoans, otk orthologous kinases are inactive. otk deviates in some consensus kinase motifs, indicating that it may be a pseudokinase. However, FBrf0055961 have shown a kinase activity associated with immunoprecipitated otk.