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General Information
Name
RECEPTOR TYROSINE KINASES
Species
D. melanogaster
Symbol
RTK
FlyBase ID
FBgg0000220
Date last reviewed
2015-08-26
Number of members
20
Description
Description

Receptor tyrosine kinases (RTK) are single-pass transmembrane receptors expressed on the plasma membrane. Upon the binding of an extracellular signalling molecule (e.g. growth factors, hormones), RTKs dimerize leading to the activation of the intracellular tyrosine kinase domain and intermolecular phosphorylation. The phosphotyrosines function as specific sites for the assembly, phosphorylation and activation of downstream signaling molecules. (Adapted from PMID:20602996).

Notes on Group

Wsck is predicted to be a pseudokinase based on sequence analysis in FBrf0209106.

drl, Drl-2 and dnt are members of the Receptor related to tyrosine kinases (RYK) subfamily. Members of this family are catalytically inactive (pseudokinases) (FBrf0222811, FBrf0132248).

In other metazoans, otk orthologous kinases are inactive. otk deviates in some consensus kinase motifs, indicating that it may be a pseudokinase. However, FBrf0055961 have shown a kinase activity associated with immunoprecipitated otk.

Source Material
The RECEPTOR TYROSINE KINASES Gene Group has been compiled by FlyBase curators using the following publication(s): Mele and Johnson, 2019, Sopko et al., 2014, Petrova et al., 2013, Sopko and Perrimon, 2013, Vogel et al., 2013, Manning et al., 2002, Halford and Stacker, 2001, and Morrison et al., 2000 .
Key Gene Ontology (GO) terms
Biological Process
Related Gene Groups
Other related group(s)
Members (20)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Anaplastic lymphoma kinase
DAlk
breathless
dev, FGFR, DFR2, FGF receptor, DFGF-R1
Cadherin 96Ca
stit, Stitcher, HD-14, DmHD-14
Discoidin domain receptor
doughnut on 2
doughnut
derailed
lio, linotte
Derailed 2
dnl, doughnut-like
Epidermal growth factor receptor
DER, top, flb, Elp, torpedo
Eph receptor tyrosine kinase
dek, Deph, CT3831, Eph receptor, lincRNA.923
heartless
DFR1, FGFR, FGF receptor, fibroblast growth factor receptor, DmHD-38
Insulin-like receptor
dInR, insulin receptor, DIR, sprout, IR
Neurospecific receptor kinase
DmHD-434, Dnrk, nrtk_dros
off-track
Dtrk, Dtkr
PDGF- and VEGF-receptor related
PDGF/VEGF receptor, VEGFR, VEGF receptor, stai
Ret oncogene
dRet, DmHD-59
Ror
Dror, DmHD-2
sevenless
DROSEV1, DmHD-265
Tie-like receptor tyrosine kinase
DPR1, RTK
External Data
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
RTK
RECEPTOR TYROSINE KINASES
Receptor Y kinases
Secondary FlyBase ID(s)
References (9)