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General Information
Name
PUTATIVE PSEUDOKINASES
Species
D. melanogaster
Symbol
PSEU-PK
FlyBase ID
FBgg0000223
Date last reviewed
2015-03-25
Number of members
25
Description
Description

Pseudokinases have a kinase domain but lack key residue(s) classically required for phosphotransfer. Although potentially lacking catalytic activity, pseudokinases may still have roles in signalling cascades and complexes. (Adapted from FBrf0209106, PMID:21074407 and PMID:23863165).

Notes on Group

The PSEUDOKINASE gene group is a collection kinase domain containing proteins which lack or have been predicted to lack phosphotransferase activity. The list has been compiled from publications and is not a comprehensive list of pseudokinases in D.mel. Pseudokinase classification by primary sequence may be unreliable - a good summary of the problems associated is provided by PMID:21074407.

p38c was thought to be a pseudokinase due to divergence in kinase motifs (FBrf0182691), but has shown to have kinase activity experimentally by FBrf0226357.

The Gyc76C and CG42637 transcription units are completely duplicated in the iso-1 reference strain genome. The duplication is a polymorphic variant that is present in the sequenced strain, but does not exist in other D.melanogaster strains (FBrf0211329).

CASK is thought to be a pseudokinase as it lacks the canonical DFG-motif required for Mg2+-binding in its CaM-kinase domain. In the absence of Mg2+ human CASK was shown to autophosphorylate and to phosphorylate bound neurexin-1 at very low catalytic rate (PMID:18423203). Its inhibition by divalent cations suggests that the kinase is inactive in vivo.

Nipped-A (aka TRRAP) encodes a pseudokinase within the phosphatidylinositol 3-kinase related kinase (PIKK) family (PMID:31769470).

Source Material
The PUTATIVE PSEUDOKINASES Gene Group has been compiled by FlyBase curators using the following publication(s): Elías-Villalobos et al., 2019, Masoner et al., 2013, Petrova et al., 2013, Cooper et al., 2010, Anamika et al., 2009, Biswas et al., 2009, Caruana, 2002, Manning et al., 2002, and Halford and Stacker, 2001 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
Cellular Component
Related Gene Groups
Members (25)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
CASK
Camguk, Caki, cmg, dCASK, CASK ortholog
Derailed 2
dnl, doughnut-like
Guanylyl cyclase at 32E
GC, Guanyl cyclase at 32E
Guanylyl cyclase at 76C
l(3)76BDl, DrGC-1, gimli, drgc
Integrin linked kinase
l(3)78Ca
MLF1-adaptor molecule
lincRNA.S6031
Nipped-A
Tra1, TRRAP, dTra1, l(2)41Ah, dTRRAP
Poly(A) specific ribonuclease subunit PAN3
polyA-nuclease related
Slowpoke binding protein
SLO-binding protein
Ste20-like kinase
Unc-89
obscurin, BEST:HL01080, obs
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
PSEU-PK
Protein Kinase-Like Non-kinases
Pseudokinases
PKLNKs
PUTATIVE PSEUDOKINASES
PROTEIN PSEUDOKINASES (KNOWN AND PUTATIVE PSEUDOKINASES)
Secondary FlyBase ID(s)
References (10)