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General Information
Name
RECEPTOR GUANYLATE CYCLASES
Species
D. melanogaster
Symbol
RGC
FlyBase ID
FBgg0000224
Date last reviewed
2015-08-26
Number of members
8
Description
Description

Receptor guanylate cyclases are single-pass transmembrane receptors with an extracellular ligand-binding domain and intracellular guanylate cyclase and pseudokinase kinase domains. Ligand binding results in the activation of the intracellular guanylyl cyclase domain and the production of cyclic GMP from GTP. The kinase domain may have a regulatory role and may bind ATP. (Adapted from FBrf0228387).

Notes on Group

The Gyc76C and CG42637 transcription units are completely duplicated in the iso-1 reference strain genome. The duplication is a polymorphic variant that is present in the sequenced strain, but does not exist in other D.melanogaster strains (FBrf0211329).

Source Material
The RECEPTOR GUANYLATE CYCLASES Gene Group has been compiled by FlyBase curators using the following publication(s): Sopko et al., 2014, Vogel et al., 2013, Cooper et al., 2010, Anamika et al., 2009, Biswas et al., 2009, and Manning et al., 2002 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
Related Gene Groups
Members (8)
For all members:
External Data
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
RGC
RECEPTOR GUANYLATE CYCLASES
Receptor GC
Guanylyl cyclase-coupled receptors
Type 1 guanylyl cyclases
Secondary FlyBase ID(s)
References (7)