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General Information
Name
ATYPICAL PROTEIN KINASES
Species
D. melanogaster
Symbol
A-PK
FlyBase ID
FBgg0000233
Date last reviewed
2015-03-25
Number of members
17
Description
Description

Atypical kinases are protein kinases or putative protein kinases that do not share clear sequence similarity with conventional eukaryotic protein kinases, but they or their orthologs have been shown experimentally to have protein kinase activity. Atypical kinases are defined in FBrf0201870.

Notes on Group

RhoGAP1A is related to the human BCR kinase, and KinBase includes RhoGAP1A (as well as human BCR and ABR) in the "Atypical -> BCR" group of kinases (http://kinase.com/web/current/kinbase/genes/Family/BCR/). However, RhoGAP1A (and ABR) lacks sequence conservation in the N-terminal kinase domain defined in BCR (e.g. PMID:8349582), and so RhoGAP1A is not included in the FlyBase ATYPICAL PROTEIN KINASES group.

KinBase includes Nipped-A (along with TRRAP genes from other species) in the "Atypical -> PIKK (phosphatidylinositol 3-kinase related kinase) -> TRRAP" group of kinases (http://kinase.com/web/current/kinbase/genes/Subfamily/TRRAP/) and it is included here - however, all TRRAP proteins are characterized as pseudokinases (PMID:31769470).

Source Material
The ATYPICAL PROTEIN KINASES Gene Group has been compiled by FlyBase curators using the following publication(s): Sopko et al., 2014, Ishikawa et al., 2012, Ishikawa et al., 2008, Manning et al., 2002, and Morrison et al., 2000 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
Cellular Component
Related Gene Groups
Parent group(s)
Members (17)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
aarF domain containing kinase 1
Adck
aarF domain containing kinase 5
meiotic 41
mei41, ATR, mus104, mus103, mus(1)104
Nipped-A
Tra1, TRRAP, dTra1, l(2)41Ah, 41Ah
no-on-and-no-off transient C
Smg1, rst(1a)cyr, Smg
TBP-associated factor 1
dTAFII230, dTAFII250, TAFII250, Taf250, TFIID
telomere fusion
ATM, dATM, atm/tefu, ataxia telangiectasia mutated
Target of rapamycin
dTOR, mTOR, TORC1, l(2)k17004, FRAP/TOR
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
A-PK
ATYPICAL PROTEIN KINASES
Secondary FlyBase ID(s)
References (6)