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General Information
Name
PROTEIN KINASES
Species
D. melanogaster
Symbol
PK
FlyBase ID
FBgg0000234
Date last reviewed
2015-03-25
Number of members
230
Description
Description
Protein kinases are enzymes that covalently modify proteins by the addition of a phosphate group to serine, threonine and tyrosine residues typically using ATP as the phosphate donor. (Adapted from FBrf0132098).
Notes on Group

The PROTEIN KINASE groups contain protein kinase catalytic subunits only.

The grouping of protein kinase sub-families has been guided by the associated publications, Kinase.com and practical considerations.

Owing to the problems associated with classification (PMID:21074407), putative pseudokinases have been included within their respective subfamilies and indicated in the Notes on Group section of the report. A separate PUTATIVE PSEUDOKINASES gene group containing these genes has also been made for guidance, but should not be regarded as a definitive or comprehensive list.

Key Gene Ontology (GO) terms
Molecular Function
Biological Process
Cellular Component
Related Gene Groups
Parent group(s)
Members (230)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Akt kinase
Akt1, dAkt, PKB, Dakt1, dPKB
genghis khan
l(2)09373, Genghis Kahn, dMRCK
G protein-coupled receptor kinase 1
rhodopsin kinase, RK, Gprk-1
G protein-coupled receptor kinase 2
nosh
JIL-1 kinase
JIL1, Su(var)3-1, Suppressor of variegation 3-1, MSK, Su-var(3)1
Phosphoinositide-dependent kinase 1
Pk61C, dPDK1, Dstpk61, PDK, Protein kinase 61C
Protein kinase N
l(2)06736, l(2)45Ca, Protein kinase related to protein kinase N, 3-2, Dpkn
Rho kinase
Drok, ROCK, Rho-associated kinase, DRho-kinase, DRhk
Ribosomal protein S6 kinase
dS6K, S6 kinase, p70S6K, fs(3)07084, RPS6-p70-protein kinase
Ribosomal protein S6 kinase II
RSK, ign, p90 ribosomal S6 kinase, rsk2, ignorant
S6 Kinase Like
Bin4, Pk17E, 3-10, Protein kinase-like 17E
sticky
Citron, citron kinase, dck, l(3)7m-62, cit
warts
lats, Warts/Lats, large tumor suppressor, miracle-gro, LATS1
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Extracellularly regulated kinase 7
ERK
nemo
adk, Nlk, adirondack, Nemo-like kinase
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
aarF domain containing kinase 1
Adck
aarF domain containing kinase 5
female sterile (1) homeotic
fsh, Fs(1)h-L, fs(1)M16, fs(1)1456, l(1)7Da
meiotic 41
mei41, ATR, mus104, mus103, fs(1)M37
Nipped-A
Tra1, TRRAP, dTra1, l(2)41Ah, dTRRAP
no-on-and-no-off transient C
Smg1, rst(1a)cyr, Smg
TBP-associated factor 1
dTAFII250, dTAFII230, TAFII250, Taf250, TAFII230
telomere fusion
ATM, dATM, ataxia telangiectasia mutated, atm/tefu
Target of rapamycin
dTOR, mTOR, TORC1, FRAP/TOR, l(2)k17004
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
AMP-activated protein kinase α subunit
AMPK, SNF1A, AMP-activated protein kinase, EG:132E8.2, dAMPKα
bent
projectin, l(4)23, twitchin, l(4)2, CT8086
Calcium/calmodulin-dependent protein kinase I
Calcium/calmodulin-dependent protein kinase II
dCaMKII, Ca2+/calmodulin-dependent protein kinase II, l(4)16, CaM kinase II, CaM kinase
CASK
Camguk, Caki, cmg, Calcium/calmodulin-dependent protein kinase, dCASK
Death-associated protein kinase related
grapes
Chk1, lemp, 1C, dChk1, last empress
loki
mnk, Chk2, DmChk2, maternal nuclear kinase, Checkpoint kinase 2
MAP kinase activated protein-kinase-2
MK2, dMK2
par-1
l(2)k06323, MARK, partitioning defective-1, dPAR-1, dMARK
Salt-inducible kinase 2
EG:22E5.8, Salt-induced kinase 2, SIK
Stretchin-Mlck
MLCK, myosin light chain kinase, A(225), Mlc-k, Stretchin
Unc-89
obscurin, BEST:HL01080, obs
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
casein kinase IIα
CK2, CKII, CK2α, Tik, casein kinase 2
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
basket
JNK, DJNK, c-Jun N-terminal kinase, Jun N-terminal kinase, pJNK
p38b MAP kinase
p38, D-p38b, p38β, p38 mitogen-activated protein kinase, BG:DS00797.3
rolled
MAPK, ERK, dpERK, MAP kinase, pERK
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Cyclin-dependent kinase 2
cdc2c, Dmcdc2c, Cyclin E
Cyclin-dependent kinase 4
Cdk4/6, l(2)05428, dCdk4, l(2)s4639, l(2)k06503
Cyclin-dependent kinase 9
P-TEFb, Positive transcription elongation factor b
Ecdysone-induced protein 63E
L63, PFTAIRE, cdc2-63E
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Dual-specificity tyrosine phosphorylation-regulated kinase 2
smi35A, dDYRK2, smell impaired 35A, DYRK, BG:DS01523.3
Dual-specificity tyrosine phosphorylation-regulated kinase 3
Homeodomain interacting protein kinase
HIPK2
Pre-mRNA processing factor 4 kinase
BcDNA:GH04978, prp4
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
shaggy
zw3, GSK3, GSK3β, GSK-3β, GSK-3
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Abl tyrosine kinase
Abelson tyrosine kinase, Abelson, dAbl, D-abl, DROTKABL3
Activated Cdc42 kinase-like
PR2, DPR2, DmHD-11, dACK
Btk family kinase at 29A
Tec29, Dsrc28C, Tec29A, fic, dsrc29A
C-terminal Src kinase
dCsk, l(3)j1D8, l(3)S017909, flik
Focal adhesion kinase
Fak56D, Fak56, DFAK, DFak56, pFAK
FER tyrosine kinase
Fps85D, dfps85D, DmHD-179, FPS, Fps oncogene analog
hopscotch
JAK, l(1)hop, Tum, DmHD-160, Hopskotch
Src oncogene at 42A
Src, Src42, Dsrc41, Dsrc42A, dtk5
Src oncogene at 64B
Src64, Src, Src1, Dsrc64B, MRE5
Wee1 kinase
Dwee1, wee, Dwee
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Autophagy-related 1
l(3)00305, Autophagy-specific gene 1, unc-51, ULK1, DK-4
aurora A
aur, aurora, Aur-A, Aurora A kinase, ck10
aurora B
ial, Aurora B kinase, IplI-aurora-like kinase, DmAuroraB, ABK
Cdc7 kinase
l(1)G0148, l(1)G0149, l(1)G0461
I-kappaB kinase β
ird5, DmIKKβ, IKK, IKK-β, immune response deficient 5
I-kappaB kinase ε
ik2, DmIKKε, l(2)38Ea, 38D.31, IκB kinase-like 2
Inositol-requiring enzyme-1
ire-1, Ire
MLF1-adaptor molecule
lincRNA.S6031
Monopolar spindle 1
ald, dMps1, altered disjunction
Poly(A) specific ribonuclease subunit PAN3
polyA-nuclease related
pancreatic eIF-2α kinase
PERK, dPerk
PTEN-induced putative kinase 1
dPINK1, Pink
polo
Polo kinase, l(3)01673, Plk1, l(3)77Aa
Slowpoke binding protein
SLO-binding protein
Threonyl-carbamoyl synthesis 5
Prpk, p53-related protein kinase
Tousled-like kinase
l(1)G0054, BEST:GH17330, BcDNA:GH07910, EP1413
Vacuolar protein sorting 15
ird1, immune response deficient 1, immune response-deficient 1
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Protein kinase, cAMP-dependent, catalytic subunit 1
PKA, DC0, DCO, PKAc, protein kinase A
Protein kinase, cAMP-dependent, catalytic subunit 2
PKA, DC1, PKA C2
Protein kinase, cAMP-dependent, catalytic subunit 3
PKA, DC2, 5-23, cAMP-dependent protein kinase 3
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
atypical protein kinase C
DaPKC, atypical PKC, l(2)k06403, aPKCζ, PKC
inactivation no afterpotential C
PKC, eye-PKC, protein kinase C, dPKC53E(ey), PKCi
Protein C kinase 53E
PKC, protein kinase C, dPKC53E(br), dPKC, Pkc1
Protein C kinase 98E
PKC, dPKC98F, PKC 98F, protein kinase C, Pkc3
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
foraging
dg2, PKG, l(2)06860, FOR/PKG
Protein kinase, cGMP-dependent at 21D
DG1, PKG
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Anaplastic lymphoma kinase
DAlk
breathless
dev, FGFR, DFR2, DFGF-R1, FGF receptor
Cadherin 96Ca
stit, Stitcher, HD-14, DmHD-14
Discoidin domain receptor
doughnut on 2
doughnut
derailed
lio, linotte
Derailed 2
doughnut-like, dnl
Epidermal growth factor receptor
DER, top, flb, Elp, torpedo
Eph receptor tyrosine kinase
dek, lincRNA.923, Deph, CT3831, Eph receptor
heartless
DFR1, FGFR, FGF receptor, fibroblast growth factor receptor, DmHD-38
Insulin-like receptor
dInR, insulin receptor, DIR, sprout, IR
Neurospecific receptor kinase
Dnrk, DmHD-434, nrtk_dros
off-track
Dtrk, Dtkr
PDGF- and VEGF-receptor related
PDGF/VEGF receptor, VEGFR, VEGF receptor, stai
Ret oncogene
dRet, DmHD-59
Ror
Dror, DmHD-2
sevenless
DmHD-265, DROSEV1
Tie-like receptor tyrosine kinase
RTK, DPR1
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
SR Protein Kinase
dSRPK1, fs(2)abc, mat(2)synPL63
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Downstream of raf1
MEK, Dsor, MAPKK, D-mek, DRODSOR1
hemipterous
JNKK, MKK7, hp, Hemipterus, JNK kinase
MAP kinase kinase 4
dMKK4, D-MKK4, JNKK2, SEK1/MKK4
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Apoptotic signal-regulating kinase 1
Pk92B, DASK1
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
thickveins
str, Thickvein, Brk25D, l(2)04415, slater
External Data
Equivalent Group(s)
Other resource(s)

[Kinase.com](http://kinase.com/web/current/)

Synonyms and Secondary IDs
Synonym(s)
PK
PROTEIN KINASES
Secondary FlyBase ID(s)
References (23)