Gene Group: PROTEIN KINASES

General Information

Name

PROTEIN KINASES

Species

D. melanogaster

Symbol

FlyBase ID

FBgg0000234

Date last reviewed

2015-03-25

Number of members

219

Description

Protein kinases are enzymes that covalently modify proteins by the addition of a phosphate group to serine, threonine and tyrosine residues typically using ATP as the phosphate donor. (Adapted from FBrf0132098).

Notes on Group

The grouping of protein kinase sub-families has been guided by the associated publications, Kinase.com and practical considerations. Groups contain catalytic subunits only. Known/putative pseudokinases are indicated in the Notes on Group section of the relevant subfamily report but are not included in the Members table - they are instead included in the PSEUDOKINASES gene group.

Source Material

The PROTEIN KINASES Gene Group has been compiled using the following publication(s): Mele and Johnson, 2019, Braden and Neufeld, 2016, Chakrabarti et al., 2014, Sopko et al., 2014, Vogel et al., 2013, Ishikawa et al., 2012, Bartkowiak et al., 2010, Kinstrie et al., 2010, Anamika et al., 2009, Delpire, 2009, Ishikawa et al., 2008, Chang et al., 2007, Mentzel and Raabe, 2005, Manning et al., 2002, Manning et al., 2002, Shieh et al., 2002, Allemand et al., 2001, Dan et al., 2001, Liu and Kipreos, 2000, Morrison et al., 2000, Han et al., 1998, and Campbell et al., 1995 .

Key Gene Ontology (GO) terms

Molecular Function

protein kinase activity

Biological Process

protein phosphorylation

Cellular Component

Related Gene Groups

Parent group(s)

KINASES

Component group(s)

AGC-KINASES

ATYPICAL PROTEIN KINASES

CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASES

CK1 KINASES

CMGC KINASES

STE KINASES

TYROSINE KINASE-LIKE KINASES

TYROSINE KINASES

UNCLASSIFIED CONVENTIONAL PROTEIN KINASE DOMAIN KINASES

Other related group(s)

PROTEIN PHOSPHATASES

PSEUDOKINASES

Members (219)

For all members:

GO ribbon stack

	molecular function	biological process	cellular component

ATYPICAL MITOGEN ACTIVATED PROTEIN KINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Erk7

Extracellularly regulated kinase 7

ERK

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

nmo

nemo

adk, Nlk, Nemo-like kinase, adirondack

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

ATYPICAL PROTEIN KINASE C SUBFAMILY

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

aPKC

atypical protein kinase C

DaPKC, atypical PKC, l(2)k06403, aPKCζ, PKC

(Sopko et al., 2014, Manning et al., 2002, Shieh et al., 2002, Morrison et al., 2000)

ATYPICAL PROTEIN KINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Adck1

aarF domain containing kinase 1

Adck

(Sopko et al., 2014, Manning et al., 2002)

Adck5

aarF domain containing kinase 5

(Sopko et al., 2014, Manning et al., 2002)

bon

bonus

(Manning et al., 2002)

CG3008

(Sopko et al., 2014, Manning et al., 2002)

CG3631

(Ishikawa et al., 2012)

CG31145

(Ishikawa et al., 2012)

Coq8

Coenzyme Q8

(Sopko et al., 2014, Manning et al., 2002)

four-jointed

(Sopko et al., 2014, Ishikawa et al., 2012, Ishikawa et al., 2008)

fs(1)h

female sterile (1) homeotic

fsh, Fs(1)h-L, fs(1)1456, fs(1)M16, l(1)G0093

(Chang et al., 2007)

mei-41

meiotic 41

mei41, ATR, mus104, mus103, fs(1)M37

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

mTor

mechanistic Target of rapamycin

Tor, dTOR, target of rapamycin, TORC1, target-of-rapamycin

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

nonC

no-on-and-no-off transient C

Smg1, rst(1a)cyr, Smg

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Pdk

Pyruvate dehydrogenase kinase

DmPdk

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

RIOK1

RIO kinase 1

(Sopko et al., 2014, Manning et al., 2002)

RIOK2

RIO kinase 2

(Sopko et al., 2014, Manning et al., 2002)

Taf1

TBP-associated factor 1

dTAF_II230, dTAF_II250, TAF_II250, Taf250, TAF_II230

(Sopko et al., 2014, Manning et al., 2002)

tbrd-1

testis-specifically expressed bromodomain containing protein-1

(FlyBase, 2017-)

tefu

telomere fusion

ATM, dATM, atm/tefu, ataxia telangiectasia mutated

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

AMPKα

AMP-activated protein kinase α subunit

AMPK, SNF1A, AMP-activated protein kinase, EG:132E8.2, dAMPKα

(Manning et al., 2002, Morrison et al., 2000)

bent

projectin, l(4)2, twitchin, l(4)23, CT8086

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

CaMKI

Calcium/calmodulin-dependent protein kinase I

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

CaMKII

Calcium/calmodulin-dependent protein kinase II

dCaMKII, Ca2+/calmodulin-dependent protein kinase II, l(4)16, CaM kinase II, CaM kinase

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

CASK

Camguk, Caki, cmg, CASK ortholog, Calcium/calmodulin-dependent protein kinase

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

CG4629

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

CG9222

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

CG10177

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

CG17528

zyg8

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Drak

Death-associated protein kinase related

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

grp

grapes

Chk1, lemp, dChk1, 1C, last empress

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

KP78a

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

KP78b

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Lk6

Lk6 kinase

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Lkb1

Lkb1 kinase

PAR-4, dlkb1, Par4, STK11

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

lok

loki

mnk, Chk2, DmChk2, Checkpoint kinase 2, maternal nuclear kinase

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

MAPk-Ak2

MAP kinase activated protein-kinase-2

MK2, dMK2

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Nuak

Nuak family kinase

Nuak1

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

par-1

l(2)k06323, MARK, partitioning defective-1, dMARK, dPAR-1

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Pask

PAS kinase

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

PhKγ

Phosphorylase kinase γ

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

PKD

Protein Kinase D

dPKD, PKCm

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

sff

sugar-free frosting

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Sik2

Salt-inducible kinase 2

EG:22E5.8, SIK, Salt-induced kinase 2

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Sik3

Salt-inducible kinase 3

SIK

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Snrk

SNF related kinase

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

sqa

spaghetti-squash activator

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Strn-Mlck

Stretchin-Mlck

MLCK, A(225), myosin light chain kinase, Mlc-k, Stretchin

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Tssk

Testis-specific serine/threonine kinase

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

CK1 KINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Asator

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

ball

ballchen

nhk-1, BcDNA:LD09009, NHK1, trip, nucleosomal histone kinase-1

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

bsd

back seat driver

BcDNA:LD23371

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

CG2577

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

CG7094

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

CG9962

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

CG12147

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

CkIα

Casein kinase Iα

CK1, CK1α, CKI, CK I, CK1alpha

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

dco

discs overgrown

dbt, doubletime, double-time, CKIε, CK1ε

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

gish

gilgamesh

Spider, ms(3)89B, Hrr25, CKIγ, CK1γ

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

CLASSICAL PROTEIN KINASE C SUBFAMILY

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

inaC

inactivation no afterpotential C

PKC, eye-PKC, protein kinase C, PKCi, dPKC53E(ey)

(Sopko et al., 2014, Manning et al., 2002, Shieh et al., 2002, Morrison et al., 2000)

Pkc53E

Protein C kinase 53E

PKC, protein kinase C, dPKC, dPKC53E(br), Pkc1

(Sopko et al., 2014, Manning et al., 2002, Shieh et al., 2002, Morrison et al., 2000)

CONVENTIONAL MITOGEN ACTIVATED PROTEIN KINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

bsk

basket

JNK, DJNK, c-Jun N-terminal kinase, Jun N-terminal kinase, pJNK

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

p38a

p38a MAP kinase

p38, Mpk2, D-p38a, Dp38, p38 MAPK

(Chakrabarti et al., 2014, Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

p38b

p38b MAP kinase

p38, D-p38b, p38β, p38Kb, dp38b

(Chakrabarti et al., 2014, Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

p38c

p38c MAP kinase

p38, Mpk2B

(Chakrabarti et al., 2014, Sopko et al., 2014, Manning et al., 2002)

rolled

ERK, MAPK, dpERK, MAP kinase, pERK

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

CYCLIN DEPENDENT KINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Cdc2rk

Cdc2-related kinase

Dcdrk

(Sopko et al., 2014, Manning et al., 2002, Liu and Kipreos, 2000, Morrison et al., 2000)

Cdk1

Cyclin-dependent kinase 1

cdc2, Dmcdc2

(Sopko et al., 2014, Manning et al., 2002, Liu and Kipreos, 2000, Morrison et al., 2000)

Cdk2

Cyclin-dependent kinase 2

cdc2c, Dmcdc2c, Cyclin E

(Sopko et al., 2014, Manning et al., 2002, Liu and Kipreos, 2000, Morrison et al., 2000)

Cdk4

Cyclin-dependent kinase 4

Cdk4/6, l(2)05428, dCdk4, l(2)k06503, 8-6

(Sopko et al., 2014, Manning et al., 2002, Liu and Kipreos, 2000, Morrison et al., 2000)

Cdk5

Cyclin-dependent kinase 5

(Sopko et al., 2014, Manning et al., 2002, Liu and Kipreos, 2000, Morrison et al., 2000)

Cdk7

Cyclin-dependent kinase 7

Mo15, DmMO15, DmCdk7

(Sopko et al., 2014, Manning et al., 2002, Liu and Kipreos, 2000, Morrison et al., 2000)

Cdk8

Cyclin-dependent kinase 8

(Sopko et al., 2014, Manning et al., 2002, Liu and Kipreos, 2000, Morrison et al., 2000)

Cdk9

Cyclin-dependent kinase 9

P-TEFb, Positive transcription elongation factor b

(Sopko et al., 2014, Manning et al., 2002, Liu and Kipreos, 2000, Morrison et al., 2000)

Cdk12

Cyclin-dependent kinase 12

AC017581

(Sopko et al., 2014, Bartkowiak et al., 2010, Manning et al., 2002, Liu and Kipreos, 2000)

CG6800

AC014407

(Sopko et al., 2014, Manning et al., 2002, Liu and Kipreos, 2000, Morrison et al., 2000)

CG7236

AC018104

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Eip63E

Ecdysone-induced protein 63E

L63, PFTAIRE, cdc2-63E

(Sopko et al., 2014, Manning et al., 2002, Liu and Kipreos, 2000, Morrison et al., 2000)

Pitslre

group 3, cdk11, PitsIre

(Sopko et al., 2014, Manning et al., 2002, Liu and Kipreos, 2000, Morrison et al., 2000)

DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION REGULATED KINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Dyrk2

Dual-specificity tyrosine phosphorylation-regulated kinase 2

smi35A, dDYRK2, BG:DS01523.3, DYRK, smell impaired 35A

(Sopko et al., 2014, Kinstrie et al., 2010, Manning et al., 2002, Morrison et al., 2000)

Dyrk3

Dual-specificity tyrosine phosphorylation-regulated kinase 3

(Sopko et al., 2014, Kinstrie et al., 2010, Manning et al., 2002)

Hipk

Homeodomain interacting protein kinase

HIPK2

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

mnb

minibrain

DYRK1, ME-IV

(Sopko et al., 2014, Kinstrie et al., 2010, Manning et al., 2002, Morrison et al., 2000)

Prp4k

Pre-mRNA processing factor 4 kinase

BcDNA:GH04978, prp4

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

GERMINAL CENTER KINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

fray

frayed

l(3)07551, laggard, Ste20-like

(Sopko et al., 2014, Manning et al., 2002, Dan et al., 2001, Morrison et al., 2000)

GckIII

Germinal centre kinase III

wheezy, STLK3, dGCKIII

(Sopko et al., 2014, Manning et al., 2002, Dan et al., 2001, Morrison et al., 2000)

hpo

hippo

MST, dMST

(Sopko et al., 2014, Manning et al., 2002, Dan et al., 2001, Morrison et al., 2000)

hppy

happyhour

MAP4K3, EP-704

(Sopko et al., 2014, Manning et al., 2002, Dan et al., 2001, Morrison et al., 2000)

msn

misshapen

l(3)06946, l(3)j1E2, Mishappen, NIK

(Sopko et al., 2014, Manning et al., 2002, Dan et al., 2001, Morrison et al., 2000)

ninaC

neither inactivation nor afterpotential C

myosin III, DRONINAC, Nina C

(Sopko et al., 2014, Manning et al., 2002, Dan et al., 2001, Morrison et al., 2000)

Slik

Sterile20-like kinase

Plkk1

(Sopko et al., 2014, Manning et al., 2002, Dan et al., 2001, Morrison et al., 2000)

Tao

Tao-1, Tao1

(Sopko et al., 2014, Manning et al., 2002, Dan et al., 2001, Morrison et al., 2000)

GLYCOGEN SYNTHASE 3-LIKE KINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

gskt

gasket

mojoless, mjl

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Pk34A

Protein kinase at 34A

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

sgg

shaggy

zw3, GSK3, GSK3β, GSK-3β, GSK-3

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

NON-RECEPTOR TKL KINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

cdi

center divider

l(3)07013, 91F, B9.3, 91F gene

(Sopko et al., 2014, Manning et al., 2002, Manning et al., 2002, Morrison et al., 2000)

ksr

kinase suppressor of ras

l(3)j5E2, SR3-1

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

LIMK1

LIM domain kinase 1

LIMK, Dlimk, agn, agnostic, LIM kinase

(Sopko et al., 2014, Manning et al., 2002, Manning et al., 2002, Morrison et al., 2000)

Lrrk

Leucine-rich repeat kinase

LRRK2, dLRRK, dLrrk2

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

pll

pelle

(Sopko et al., 2014, Manning et al., 2002, Manning et al., 2002, Morrison et al., 2000)

Raf

Raf oncogene

D-raf, Draf, phl, pole hole, l(1)ph

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

slpr

slipper

dMLK, MLK2, MLK, JNKKK

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Tak1

TGF-β activated kinase 1

dTAK1, dTAK, TAK, dTAK-1, DmTak1

(Sopko et al., 2014, Manning et al., 2002, Manning et al., 2002, Morrison et al., 2000)

Takl1

Tak1-like 1

(Sopko et al., 2014, Manning et al., 2002, Manning et al., 2002, Morrison et al., 2000)

Takl2

Tak1-like 2

(Sopko et al., 2014, Manning et al., 2002, Manning et al., 2002, Morrison et al., 2000)

wnd

wallenda

DLK

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

NON-RECEPTOR TYROSINE KINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Abl

Abl tyrosine kinase

Abelson tyrosine kinase, Abelson, dAbl, D-abl, Abelson kinase

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Ack

Activated Cdc42 kinase

DACK, p145

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Ack-like

Activated Cdc42 kinase-like

PR2, DPR2, dACK, DmHD-11

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Btk

Bruton tyrosine kinase

Btk29A, Tec29, Dsrc28C, Tec29A, fic

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Csk

C-terminal Src kinase

dCsk, l(3)j1D8, flik, Src, l(3)S017909

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Fak

Focal adhesion kinase

Fak56D, Fak56, DFak56, DFAK, pFAK

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

FER

FER tyrosine kinase

Fps85D, dfps85D, DmHD-179, Fps oncogene analog, Dfer

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

hop

hopscotch

JAK, tu-Sz, Tum, DmHD-160, l(1)hop

(Morrison et al., 2000)

Shark

SH2 ankyrin repeat kinase

dtk7

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Src42A

Src oncogene at 42A

Src, Src42, Dsrc41, Dsrc42A, DmHD-29

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Src64B

Src oncogene at 64B

Src64, Src, Dsrc64B, Src1, Dsrc

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Wee1

Wee1 kinase

Dwee1, wee, Dwee

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000, Campbell et al., 1995)

NOVEL PROTEIN KINASE C SUBFAMILY

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Pkc98E

Protein C kinase 98E

PKC, dPKC98F, PKC 98F, protein kinase C, Pkc3

(Sopko et al., 2014, Manning et al., 2002, Shieh et al., 2002, Morrison et al., 2000)

Pkcδ

Protein kinase C δ

PKCd

(Sopko et al., 2014, Manning et al., 2002, Shieh et al., 2002, Morrison et al., 2000)

P21-ACTIVATED KINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

mbt

mushroom bodies tiny

Pak2, Ste20, dPAK2

(Sopko et al., 2014, Mentzel and Raabe, 2005, Manning et al., 2002, Dan et al., 2001, Morrison et al., 2000)

Pak

p21-activated kinase

DPAK, Pak1, dPAK1, p65^PAK, PAK-kinase

(Sopko et al., 2014, Delpire, 2009, Mentzel and Raabe, 2005, Manning et al., 2002, Dan et al., 2001, Morrison et al., 2000)

Pak3

dpak3, DmPAK3

(Sopko et al., 2014, Mentzel and Raabe, 2005, Manning et al., 2002, Dan et al., 2001, Morrison et al., 2000)

PROTEIN KINASE A FAMILY

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG12069

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Pka-C1

Protein kinase, cAMP-dependent, catalytic subunit 1

PKA, DC0, DCO, PKAc, protein kinase A

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Pka-C2

Protein kinase, cAMP-dependent, catalytic subunit 2

PKA, DC1, PKA C2

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Pka-C3

Protein kinase, cAMP-dependent, catalytic subunit 3

PKA, DC2, cAMP-dependent protein kinase 3, 5-23

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

PROTEIN KINASE G FAMILY

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG4839

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

for

foraging

dg2, PKG, l(2)06860, FOR/PKG

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Pkg21D

Protein kinase, cGMP-dependent at 21D

DG1, PKG

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

RECEPTOR TYROSINE KINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Alk

Anaplastic lymphoma kinase

DAlk

(Mele and Johnson, 2019)

btl

breathless

dev, FGFR, DFR2, DFGF-R1, FGF receptor

(Mele and Johnson, 2019)

Cad96Ca

Cadherin 96Ca

stit, Stitcher, HD-14, DmHD-14

(Mele and Johnson, 2019)

CG3277

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Ddr

Discoidin domain receptor

(Mele and Johnson, 2019)

Egfr

Epidermal growth factor receptor

DER, top, flb, Elp, torpedo

(Mele and Johnson, 2019)

Eph

Eph receptor tyrosine kinase

dek, Deph, lincRNA.923, Eph receptor, CT3831

(Mele and Johnson, 2019)

htl

heartless

DFR1, FGFR, FGF receptor, fibroblast growth factor receptor, DmHD-38

(Mele and Johnson, 2019)

InR

Insulin-like receptor

dInR, insulin receptor, DIR, sprout, InsR

(Mele and Johnson, 2019)

Nrk

Neurospecific receptor kinase

DmHD-434, Dnrk, nrtk_dros

(Mele and Johnson, 2019)

otk

off-track

Dtrk, Dtkr

(Mele and Johnson, 2019)

Pvr

PDGF- and VEGF-receptor related

PDGF/VEGF receptor, VEGFR, VEGF receptor, stai

(Mele and Johnson, 2019)

Ret

Ret oncogene

dRet, DmHD-59

(Mele and Johnson, 2019)

Ror

RTK-like orphan receptor

Dror, DmHD-2

(Mele and Johnson, 2019)

sev

sevenless

DmHD-265, DROSEV1

(Mele and Johnson, 2019)

Tie

Tie-like receptor tyrosine kinase

RTK, DPR1

(Mele and Johnson, 2019)

tor

torso

splc

(Mele and Johnson, 2019)

SERINE-ARGININE PROTEIN KINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG8565

(Sopko et al., 2014, Manning et al., 2002, Allemand et al., 2001, Morrison et al., 2000)

SRPK

SR Protein Kinase

fs(2)abc, mat(2)synPL63, dSRPK1

(Sopko et al., 2014, Manning et al., 2002, Allemand et al., 2001)

Srpk79D

Serine-arginine protein kinase at 79D

BEST:CK01209

(Sopko et al., 2014, Manning et al., 2002, Allemand et al., 2001, Morrison et al., 2000)

STE7 MAP KINASE KINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Dsor1

Downstream of raf1

MEK, Dsor, MAPKK, DRODSOR1, D-mek

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000, Han et al., 1998)

hep

hemipterous

JNKK, MKK7, hp, l(1)G0107, JNK kinase

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000, Han et al., 1998)

lic

licorne

MKK3, DMEK3, D-MKK3, DMKK3, p38

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000, Han et al., 1998)

Mkk4

MAP kinase kinase 4

dMKK4, D-MKK4, JNKK2, SEK1/MKK4

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000, Han et al., 1998)

STE11 MAP KINASE KINASE KINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Ask1

Apoptotic signal-regulating kinase 1

Pk92B, DASK1

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Mekk1

dMEKK1, D-MEKK1, MEKK4

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

TGF-BETA TYPE II RECEPTORS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

put

punt

Atr-II, l(3)10460, TGF-β

(Sopko et al., 2014, Vogel et al., 2013, Manning et al., 2002, Morrison et al., 2000)

wit

wishful thinking

l(3)64Aa, STK-D, SE20

(Sopko et al., 2014, Vogel et al., 2013, Manning et al., 2002, Morrison et al., 2000)

TGF-BETA TYPE I RECEPTORS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

babo

baboon

Atr-I, Atr-1, AtrI, Activin A receptor 45A, Atr45A

(Sopko et al., 2014, Vogel et al., 2013, Manning et al., 2002, Morrison et al., 2000)

sax

saxophone

Brk43E

(Sopko et al., 2014, Vogel et al., 2013, Manning et al., 2002, Morrison et al., 2000)

tkv

thickveins

str, Thickvein, l(2)04415, Brk25D, slater

(Sopko et al., 2014, Vogel et al., 2013, Manning et al., 2002, Morrison et al., 2000)

UNCLASSIFIED AGC KINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Akt

Akt kinase

Akt1, dAkt, PKB, Dakt1, dPKB

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

CG7156

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

CG32944

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

dop

drop out

MAST205

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

gek

genghis khan

l(2)09373, Genghis Kahn, dMRCK

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Gprk1

G protein-coupled receptor kinase 1

rhodopsin kinase, RK, Gprk-1

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Gprk2

G protein-coupled receptor kinase 2

nosh

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

gwl

greatwall

Pk91C, 1J

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

JIL-1

JIL-1 kinase

JIL1, Su(var)3-1, Suppressor of variegation 3-1, Su-var(3)1, MSK

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Pdk1

Phosphoinositide-dependent kinase 1

Pk61C, dPDK1, Dstpk61, PDK, PDK-1

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Pkn

Protein kinase N

l(2)06736, l(2)45Ca, Protein kinase related to protein kinase N, Dpkn, 3-2

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Rok

Rho kinase

Drok, ROCK, Rho-associated kinase, DRho-kinase, ROCK1

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

S6k

Ribosomal protein S6 kinase

dS6K, S6 kinase, p70S6K, fs(3)07084, RPS6-p70-protein kinase

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

S6kII

Ribosomal protein S6 kinase II

RSK, ign, ignorant, rsk2, p90 ribosomal S6 kinase

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

S6KL

S6 Kinase Like

Bin4, Pk17E, 3-10, Protein kinase-like 17E

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

sti

sticky

Citron, citron kinase, dck, cit, l(3)7m-62

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

trc

tricornered

Ndr, tricorner

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

wts

warts

lats, large tumor suppressor, Warts/Lats, miracle-gro, Lats/Warts

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

UNCLASSIFIED CMGC KINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG42366

MAK

(Morrison et al., 2000)

CkIIα

casein kinase IIα

CK2, CKII, CK2α, Tik, Timekeeper

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Doa

Darkener of apricot

Msu

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

UNCLASSIFIED CONVENTIONAL PROTEIN KINASE DOMAIN KINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Aduk

Another Drosophila Unc-51-like kinase

(Braden and Neufeld, 2016, Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Atg1

Autophagy-related 1

l(3)00305, Autophagy-specific gene 1, unc-51, ULK1, dAtg1

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

aurA

aurora A

aur, aurora, Aur-A, Aurora A kinase, aurka

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

aurB

aurora B

ial, Aurora B kinase, ABK, IplI-aurora-like kinase, DmAuroraB

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

aux

auxilin

auxillin, dAux

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Bub1

Bub1 kinase

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

BubR1

Bub1-related kinase

bub1, l(2)k03113

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Cdc7

Cdc7 kinase

l(1)G0148, l(1)G0461, l(1)G0149

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

CG1227

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

CG4945

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

CG5790

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

CG8173

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

CG17698

CAMKIIB

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

fused

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Gcn2

dGCN2

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Haspin

(Sopko et al., 2014, Manning et al., 2002)

IKKβ

I-kappaB kinase β

ird5, DmIKKβ, IKK, IKK-β, immune response deficient 5

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

IKKε

I-kappaB kinase ε

ik2, DmIKKε, l(2)38Ea, 38D.31, IκB kinase-like 2

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Ire1

Inositol-requiring enzyme-1

ire-1, Ire1α, Ire

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

meng

meng-po

PKN

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Mos

Mos oncogene

dmos

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Mps1

Monopolar spindle 1

ald, altered disjunction, dMps1

(Sopko et al., 2014, Manning et al., 2002)

Myt1

Dmyt1

(Sopko et al., 2014, Manning et al., 2002)

Nak

Numb-associated kinase

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Nek2

DmNek2, dNek2

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

niki

nimA-like kinase

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

PEK

pancreatic eIF-2α kinase

PERK, dpERK

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Pink1

PTEN-induced putative kinase 1

dPINK1

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

png

pan gu

EG:8D8.5, fs(1)M2

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

polo

Polo kinase, l(3)01673, Plk1, l(3)77Aa

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

SAK

Sak kinase

Plk4

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Slob

Slowpoke binding protein

SLO-binding protein

(Sopko et al., 2014, Anamika et al., 2009, Manning et al., 2002)

Tcs5

Threonyl-carbamoyl synthesis 5

Prpk, p53-related protein kinase

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Tlk

Tousled-like kinase

l(1)G0054, BcDNA:GH07910, EP1413, BEST:GH17330

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Vps15

Vacuolar protein sorting 15

ird1, immune response deficient 1, immune response-deficient 1

(Sopko et al., 2014, Manning et al., 2002)

Wnk

Wnk kinase

DmWNK

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

External Data

Equivalent Group(s)

Other resource(s)

[Kinase.com](http://kinase.com/web/current/)

Synonyms and Secondary IDs

Synonym(s)

PROTEIN KINASES

Secondary FlyBase ID(s)

References (24)

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