Gene Group: OTHER CONVENTIONAL PROTEIN KINASE DOMAIN KINASES

General Information

Name

OTHER CONVENTIONAL PROTEIN KINASE DOMAIN KINASES

Species

D. melanogaster

Symbol

O-PK

FlyBase ID

FBgg0000248

Date last reviewed

2022-03-01

Number of members

Description

The group of 'other conventional protein kinase domain kinases' consists of kinases with a conventional eukaryotic protein kinase domain that do not fit into any of the other major groups. This grouping is described in FBrf0201870.

Notes on Group

Although Wee1 is functionally a tyrosine kinase, its sequence is more similar to serine/threonine kinases (PMID:15837193). It is therefore listed in both OTHER CONVENTIONAL PROTEIN KINASE DOMAIN KINASES and NON-RECEPTOR TYROSINE KINASES gene groups.

Madm, CG8726, CG4041 and PAN3 are predicted to be pseudokinases based on sequence analysis in FBrf0209106 and are therefore listed in the PUTATIVE PSEUDOKINASES gene group as well.

Slob was predicted to be a pseudokinase in FBrf0209106, but was shown to be active in FBrf0179534.

Wnk was predicted to be a pseudokinase in FBrf0209106, but was shown to be active in FBrf0222370.

Source Material

The OTHER CONVENTIONAL PROTEIN KINASE DOMAIN KINASES Gene Group has been compiled by FlyBase curators using the following publication(s): Braden and Neufeld, 2016, Sopko et al., 2014, Anamika et al., 2009, Manning et al., 2002, and Morrison et al., 2000 .

Key Gene Ontology (GO) terms

Molecular Function

protein serine/threonine kinase activity

Biological Process

protein phosphorylation

Cellular Component

Related Gene Groups

Parent group(s)

PROTEIN KINASES

Members (40)

For all members:

GO ribbon stack

	molecular function	biological process	cellular component

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Aduk

Another Drosophila Unc-51-like kinase

(Braden and Neufeld, 2016, Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Atg1

Autophagy-related 1

l(3)00305, Autophagy-specific gene 1, unc-51, DK-4, ULK1

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

aurA

aurora A

aur, aurora, Aur-A, Aurora A kinase, l(3)ck10

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

aurB

aurora B

ial, Aurora B kinase, DmAuroraB, ABK, IplI-aurora-like kinase

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

aux

auxilin

auxillin, dAux

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Bub1

Bub1 kinase

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

BubR1

Bub1-related kinase

bub1, l(2)k03113

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Cdc7

Cdc7 kinase

l(1)G0148, l(1)G0149, l(1)G0461

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

CG1227

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

CG4041

(Sopko et al., 2014, Anamika et al., 2009, Manning et al., 2002, Morrison et al., 2000)

CG4945

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

CG5790

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

CG8173

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

CG8726

(Sopko et al., 2014, Anamika et al., 2009, Manning et al., 2002, Morrison et al., 2000)

CG17698

CAMKIIB

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

fused

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Gcn2

dGCN2

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Haspin

(Sopko et al., 2014, Manning et al., 2002)

IKKβ

I-kappaB kinase β

ird5, DmIKKβ, IKK, IKK-β, immune response deficient 5

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

IKKε

I-kappaB kinase ε

ik2, DmIKKε, l(2)38Ea, 38D.31, IκB kinase-like 2

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Ire1

Inositol-requiring enzyme-1

ire-1, Ire

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Madm

MLF1-adaptor molecule

lincRNA.S6031

(Anamika et al., 2009)

meng

meng-po

PKN

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Mos

Mos oncogene

dmos

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Mps1

Monopolar spindle 1

ald, dMps1, altered disjunction

(Sopko et al., 2014, Manning et al., 2002)

Myt1

Dmyt1

(Sopko et al., 2014, Manning et al., 2002)

Nak

Numb-associated kinase

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Nek2

DmNek2, dNek2

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

niki

nimA-like kinase

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

PAN3

Poly(A) specific ribonuclease subunit PAN3

polyA-nuclease related

(Sopko et al., 2014, Anamika et al., 2009)

PEK

pancreatic eIF-2α kinase

PERK, dPerk

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Pink1

PTEN-induced putative kinase 1

dPINK1, Pink

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

png

pan gu

EG:8D8.5, fs(1)M2

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

polo

Polo kinase, l(3)01673, Plk1, l(3)77Aa

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

SAK

Sak kinase

Plk4

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Slob

Slowpoke binding protein

SLO-binding protein

(Sopko et al., 2014, Anamika et al., 2009, Manning et al., 2002)

Tcs5

Threonyl-carbamoyl synthesis 5

Prpk, p53-related protein kinase

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Tlk

Tousled-like kinase

l(1)G0054, BcDNA:GH07910, BEST:GH17330, EP1413

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

Vps15

Vacuolar protein sorting 15

ird1, immune response deficient 1, immune response-deficient 1

(Sopko et al., 2014, Manning et al., 2002)

Wnk

Wnk kinase

(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)

External Data

Equivalent Group(s)

Other resource(s)

Synonyms and Secondary IDs

Synonym(s)

O-PK

OTHER CONVENTIONAL PROTEIN KINASE DOMAIN KINASES

Secondary FlyBase ID(s)

References (6)

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