FB2020_06, released Dec 22, 2020

Gene Group : OTHER CONVENTIONAL PROTEIN KINASE DOMAIN KINASES

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General Information
Name
OTHER CONVENTIONAL PROTEIN KINASE DOMAIN KINASES
Species
D. melanogaster
Symbol
O-PK
FlyBase ID
FBgg0000248
Date last reviewed
2015-03-25
Number of members
41
Description
Description

The group of 'other conventional protein kinase domain kinases' consists of kinases with a conventional eukaryotic protein kinase domain that do not fit into any of the other major groups. This grouping is described in FBrf0201870.

Notes on Group

Although Wee1 is functionally a tyrosine kinase, its sequence more similar to serine/threonine kinases (PMID:15837193). It is therefore listed in both OTHER CONVENTIONAL PROTEIN KINASE DOMAIN KINASES and NON-RECEPTOR TYROSINE KINASES gene groups.

Madm, Slob, CG8726, CG4041 and CG11486 are predicted to be pseudokinases based on sequence analysis in FBrf0209106. Wnk was predicted to be a pseudokinase in FBrf0209106, but was shown to be active in FBrf0222370.

Source Material
The OTHER CONVENTIONAL PROTEIN KINASE DOMAIN KINASES Gene Group has been compiled by FlyBase curators using the following publication(s): Braden and Neufeld, 2016, Sopko et al., 2014, Anamika et al., 2009, Manning et al., 2002, and Morrison et al., 2000 .
Key Gene Ontology (GO) terms
Molecular Function
protein serine/threonine kinase activity
Biological Process
protein phosphorylation
Cellular Component
Related Gene Groups
Parent group(s)
PROTEIN KINASES
Members (41)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Aduk
Another Drosophila Unc-51-like kinase
(Braden and Neufeld, 2016, Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
Atg1
Autophagy-related 1
l(3)00305, Autophagy-specific gene 1, unc-51, DK-4, unc51
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
aurA
aurora A
aur, aurora, Aur-A, Aurora A kinase, l(3)ck10
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
aurB
aurora B
ial, Aurora B kinase, ABK, IplI-aurora-like kinase, DmAuroraB
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
aux
auxilin
auxillin, dAux
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
Bub1
Bub1 kinase
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
BubR1
Bub1-related kinase
bub1, l(2)k03113
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
Cdc7
Cdc7 kinase
l(1)G0148, l(1)G0149, l(1)G0461
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
CG1227
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
CG4041
(Sopko et al., 2014, Anamika et al., 2009, Manning et al., 2002, Morrison et al., 2000)
CG4945
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
CG5790
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
CG8173
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
CG8726
(Sopko et al., 2014, Anamika et al., 2009, Manning et al., 2002, Morrison et al., 2000)
CG17698
CAMKIIB
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
fu
fused
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
Gcn2
Gcn2
dGCN2
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
Haspin
Haspin
(Sopko et al., 2014, Manning et al., 2002)
IKKβ
I-kappaB kinase β
ird5, DmIKKβ, IKK, IKK-β, immune response deficient 5
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
IKKε
I-kappaB kinase ε
ik2, DmIKKε, l(2)38Ea, 38D.31, IκB kinase-like 2
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
Ire1
Inositol-requiring enzyme-1
ire-1, Ire
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
Madm
MLF1-adaptor molecule
lincRNA.S6031
(Anamika et al., 2009)
meng
meng-po
PKN
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
Mos
Mos oncogene
dmos
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
Mps1
Monopolar spindle 1
ald, dMps1, altered disjunction
(Sopko et al., 2014, Manning et al., 2002)
Myt1
Myt1
Dmyt1
(Sopko et al., 2014, Manning et al., 2002)
Nak
Numb-associated kinase
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
Nek2
Nek2
dNek2, DmNek2
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
niki
nimA-like kinase
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
PAN3
Poly(A) specific ribonuclease subunit PAN3
polyA-nuclease related
(Sopko et al., 2014, Anamika et al., 2009)
PEK
pancreatic eIF-2α kinase
PERK, dPerk
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
Pink1
PTEN-induced putative kinase 1
dPINK1, Pink
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
png
pan gu
fs(1)M2, EG:8D8.5
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
polo
polo
Polo kinase, l(3)01673, l(3)77Aa, Plk1
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
SAK
Sak kinase
Plk4
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
Slob
Slowpoke binding protein
SLO-binding protein
(Sopko et al., 2014, Anamika et al., 2009, Manning et al., 2002)
Tcs5
Threonyl-carbamoyl synthesis 5
Prpk, p53-related protein kinase
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
Tlk
Tousled-like kinase
l(1)G0054, BEST:GH17330, BcDNA:GH07910, EP1413
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
Vps15
Vacuolar protein sorting 15
ird1, immune response deficient 1, immune response-deficient 1
(Sopko et al., 2014, Manning et al., 2002)
Wee1
Wee1 kinase
Dwee1, wee, Dwee
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
Wnk
Wnk kinase
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
O-PK
OTHER CONVENTIONAL PROTEIN KINASE DOMAIN KINASES
Secondary FlyBase ID(s)
References (6)