The Haloacid Dehalogenase (HAD) family members are hydrolases characterised by a conserved α/β-domain Rossmann fold-like domain and three additional domains: squiggle, flap and cap domains, that contribute to substrate specificity. HADs are aspartate-nucleophile hydrolases, using a aspartate residue for nucleophilic attack. The HAD non-protein phosphatase group is a collection of HADs that belong to subgroups that dephosphorylate non-protein substrates such as nucleosides, lipids and sugars. (Adapted from FBrf0228712).
Notes on Group
Although included in the list of HAD phosphatases in FBrf0228712, CG5177 was shown to lack trehalose-phosphatase activity in FBrf0233011 and is therefore excluded from this group.
