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General Information
Name
POLYCOMB REPRESSIVE COMPLEX 1 (CORE SUBUNITS)
Species
D. melanogaster
Symbol
PRC1
FlyBase ID
FBgg0000273
Date last reviewed
2016-07-19
Number of members
5
Description
Description
The Polycomb repressive complex 1 (PRC1) is a Polycomb group complex. It binds to histone H3K27me3 (histone H3 K27 methylation is catalyzed by PRC2) and monoubiquitinates H2A on K119. This leads to chromatin compaction, RNA polymerase II stalling and gene silencing. (Adapted from FBrf0179742 and FBrf0228921).
Notes on Group
This list does not include Scm which is less strongly associated with PRC1 (FBrf0228921). PRC1 may interact with various other factors, giving rise to multiple PRC1-like complexes with differing activities (FBrf0220020, FBrf0228971 and FBrf0232732).
Source Material
The POLYCOMB REPRESSIVE COMPLEX 1 (CORE SUBUNITS) Gene Group has been compiled by FlyBase curators using the following publication(s): Piunti and Shilatifard, 2016, Grossniklaus and Paro, 2014, and Lanzuolo and Orlando, 2012.
Key Gene Ontology (GO) terms
Cellular Component
Related Gene Groups
Members (5)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
polyhomeotic distal
ph, Polyhomeotic, EG:BACN25G24.3, DROZFP, PHD
polyhomeotic proximal
ph, Polyhomeotic, EG:87B1.5, PHP, ph-proximal
Sex combs extra
dRING, dRING1, Ring, Sex comb extra, RING1
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
PRC1
POLYCOMB REPRESSIVE COMPLEX 1 (CORE SUBUNITS)
PRC1 complex
Secondary FlyBase ID(s)
References (4)