FB2025_01 , released February 20, 2025
Complex: TRX COMPLEX
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General Information
Name
TRX COMPLEX
Species
D. melanogaster
Symbol
TRX-C
FlyBase ID
FBgg0000285
Date last reviewed
2023-08-08
Number of members
7
Description
Description
The Trithorax (Trx) complex is a COMPASS-like complex that mediates methylation of histone H3K4. (Adapted from FBrf0216343).
Notes on Group
Source Material
The TRX COMPLEX Gene Group has been compiled using the following publication(s): Piunti and Shilatifard, 2016, Shilatifard, 2012, Mohan et al., 2011, and Schuettengruber et al., 2011 .
Key Gene Ontology (GO) terms
Molecular Function
histone H3K4 methyltransferase activity
Biological Process
chromatin remodeling
Cellular Component
MLL1/2 complex
Related Gene Groups
Parent group(s)
COMPASS-TYPE COMPLEXES
Members (7)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
ash2
absent, small, or homeotic discs 2
ash-2
(Piunti and Shilatifard, 2016, Mohan et al., 2011, Schuettengruber et al., 2011)
Dpy-30L1
Dpy-30-like 1
Dpy30
(Piunti and Shilatifard, 2016, Mohan et al., 2011, Schuettengruber et al., 2011)
Hcf
Host cell factor
dHCF, Hcf1, dHcf1
(Piunti and Shilatifard, 2016, Mohan et al., 2011, Schuettengruber et al., 2011)
Mnn1
Menin 1
menin, MEN1
(Piunti and Shilatifard, 2016, Mohan et al., 2011, Schuettengruber et al., 2011)
Rbbp5
Retinoblastoma binding protein 5
dRbbp5
(Piunti and Shilatifard, 2016, Mohan et al., 2011, Schuettengruber et al., 2011)
trx
trithorax
trxG, l(3)j14A6, Rg-bx, Trx-C, DMTRXIII
(Piunti and Shilatifard, 2016, Mohan et al., 2011, Schuettengruber et al., 2011)
wds
will die slowly
zw8, l(1)zw8, zw-8, EG:BACR25B3.7, l(1)3Ad
(Piunti and Shilatifard, 2016, Mohan et al., 2011, Schuettengruber et al., 2011)
External Data
Synonyms and Secondary IDs
Synonym(s)
TRX COMPLEX
Trithorax complex proteins associated with Set1-LIKE
Myeloid/Lymphoid Leukemia1/2 Complex
Trx Methylase
COMPASS-like complex
MLL1/2 complex
MLL1/2
TRX
TRX-C
Secondary FlyBase ID(s)
References (5)