FB2025_02 , released April 17, 2025
Complex: TIP60 COMPLEX
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General Information
Name
TIP60 COMPLEX
Species
D. melanogaster
Symbol
TIP60
FlyBase ID
FBgg0000287
Date last reviewed
2023-08-08
Number of members
16
Description
Description
The Tip60 chromatin remodeling complex acetylates nucleosomal phospho-histone H2Av and exchanges it with unmodified H2Av. (Adapted from FBrf0185742).
Notes on Group

Different isoforms of the dom Snf2-like ATPase are present in the Tip60 histone acetyltransferase complex and the SWR1 chromatin remodeling complex. Isoform dom-PA is associated with Tip60 and dom-PB with SWR1 (FBrf0245697).

Source Material
The TIP60 COMPLEX Gene Group has been compiled using the following publication(s): Scacchetti et al., 2020, Clapier and Cairns, 2009, and Kusch et al., 2004 .
Key Gene Ontology (GO) terms
Molecular Function
histone acetyltransferase activity
Biological Process
chromatin remodeling
Cellular Component
NuA4 histone acetyltransferase complex
Enzymatic activity
Enzyme name (EC)
histone acetyltransferase (2.3.1.48)
Related Gene Groups
Parent group(s)
CHROMATIN MODIFYING COMPLEXES
CHROMATIN REMODELING COMPLEXES (ATP-DEPENDENT)
Members (16)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
TIP60
SWRI complex
Nu4A complex
SWRI
Nu4A
TIP60 COMPLEX
DOM-A complex
DOM-A.C
Secondary FlyBase ID(s)
References (4)