FB2025_01 , released February 20, 2025
Complex: SAGA COMPLEX
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General Information
Name
SAGA COMPLEX
Species
D. melanogaster
Symbol
SAGA
FlyBase ID
FBgg0000305
Date last reviewed
2023-08-08
Number of members
21
Description
Description
The Spt-Ada-Gcn5 Acetyltransferase (SAGA) complex is a chromatin modifying complex. SAGA can acetylate and deubiquitinate histone residues. Also SAGA has been shown to regulate the transcriptional activation of a subset of genes. (Adapted from FBrf0228923, FBrf0219841 and FBrf0233349).
Notes on Group

SAGA has 3 subunits in common with the ATAC complex (Gcn5, Ada3, Sgf29).

Sf3b3 and Sf3b5 are spliceosomal components of the U2 small nuclear ribonucleoprotein particle (snRNP) and have been also identified as subunits of the Drosophila SAGA (FBrf0233349). Note that in human one U2 snRNP spliceosomal subunit was identified in a SAGA-like complex (PMID:11564863).

Source Material
The SAGA COMPLEX Gene Group has been compiled using the following publication(s): Stegeman et al., 2016, Spedale et al., 2012, Weake et al., 2011, Rodriguez-Navarro, 2009, and Weake et al., 2008 .
Key Gene Ontology (GO) terms
Molecular Function
histone acetyltransferase activity
cysteine-type deubiquitinase activity
Biological Process
regulation of transcription by RNA polymerase II
Cellular Component
SAGA complex
Enzymatic activity
Enzyme name (EC)
histone acetyltransferase (2.3.1.48)
ubiquitinyl hydrolase 1 (3.4.19.12)
Related Gene Groups
Parent group(s)
GCN5-CONTAINING COMPLEXES
Protein Complex group(s)
ADA COMPLEX
ATAC COMPLEX
CHAT COMPLEX
Members (21)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Ada1-1
transcriptional Adaptor 1-1
Ada1
(Spedale et al., 2012, Weake et al., 2011, Rodriguez-Navarro, 2009)
Ada1-2
transcriptional Adaptor 1-2
Ada1
(Stegeman et al., 2016, Spedale et al., 2012, Weake et al., 2011, Rodriguez-Navarro, 2009, Weake et al., 2008)
Ada2b
transcriptional Adaptor 2b
dAda2b
(Stegeman et al., 2016, Spedale et al., 2012, Weake et al., 2011, Rodriguez-Navarro, 2009, Weake et al., 2008)
Ada3
transcriptional Adaptor 3
dAda3, dik, diskette
(Stegeman et al., 2016, Spedale et al., 2012, Weake et al., 2011, Rodriguez-Navarro, 2009)
Atxn7
Ataxin 7
(Stegeman et al., 2016, Spedale et al., 2012, Weake et al., 2011)
e(y)2
enhancer of yellow 2
ENY2, late boundary complex, LBC
(Stegeman et al., 2016, Spedale et al., 2012, Weake et al., 2011, Rodriguez-Navarro, 2009)
Gcn5
Gcn5 acetyltransferase
dGcn5, Pcaf, dmGCN5, dKAT2, KAT
(Stegeman et al., 2016, Spedale et al., 2012, Weake et al., 2011, Rodriguez-Navarro, 2009, Weake et al., 2008)
Nipped-A
Nipped-A
Tra1, TRRAP, dTra1, l(2)41Ah, dTRRAP
(Stegeman et al., 2016, Spedale et al., 2012, Weake et al., 2011, Rodriguez-Navarro, 2009)
not
non-stop
l(3)02069
(Stegeman et al., 2016, Spedale et al., 2012, Weake et al., 2011, Rodriguez-Navarro, 2009, Weake et al., 2008)
Saf6
SAGA factor-like TAF6
(Stegeman et al., 2016, Spedale et al., 2012, Weake et al., 2011)
Sf3b3
Splicing factor 3b subunit 3
(Stegeman et al., 2016)
Sf3b5
Splicing factor 3b subunit 5
(Stegeman et al., 2016)
Sgf11
SAGA associated factor 11kDa
dSgf11
(Stegeman et al., 2016, Spedale et al., 2012, Weake et al., 2011, Rodriguez-Navarro, 2009, Weake et al., 2008)
Sgf29
SAGA-associated factor 29kDa
dSgf29
(Stegeman et al., 2016, Spedale et al., 2012, Weake et al., 2011, Rodriguez-Navarro, 2009, Weake et al., 2008)
Spt3
Spt3
dSpt3
(Stegeman et al., 2016, Spedale et al., 2012, Weake et al., 2011, Rodriguez-Navarro, 2009, Weake et al., 2008)
Spt7
Spt7
dSpt7
(Stegeman et al., 2016, Spedale et al., 2012, Weake et al., 2011, Rodriguez-Navarro, 2009)
Spt20
Spt20
lincRNA.S5070
(Stegeman et al., 2016, Spedale et al., 2012, Weake et al., 2011)
Taf9
TBP-associated factor 9
dTAFII40, e(y)1, dTAFII42, TAFII40, TFIID
(Stegeman et al., 2016, Spedale et al., 2012, Weake et al., 2011, Rodriguez-Navarro, 2009)
Taf10b
TBP-associated factor 10b
TFIID, dTAFII16, TAFII16
(Stegeman et al., 2016, Spedale et al., 2012, Weake et al., 2011, Rodriguez-Navarro, 2009)
Taf12
TBP-associated factor 12
TBP-associated factor 30kD subunit α, Taf30α, dTAFII30α, TFIID, dTAFII30
(Stegeman et al., 2016, Spedale et al., 2012, Weake et al., 2011, Rodriguez-Navarro, 2009)
wda
will decrease acetylation
(Stegeman et al., 2016, Spedale et al., 2012, Weake et al., 2011, Rodriguez-Navarro, 2009, Weake et al., 2008)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
SAGA
SAGA complex
SPT-ADA-GCN5 ACETYLTRANSFERASE
SAGA COMPLEX
Secondary FlyBase ID(s)
References (6)