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General Information
Name
SAGA COMPLEX
Species
D. melanogaster
Symbol
SAGA
FlyBase ID
FBgg0000305
Date last reviewed
2016-11-09
Number of members
21
Description
Description

The Spt-Ada-Gcn5 Acetyltransferase (SAGA) complex is a chromatin modifying complex. SAGA can acetylate and deubiquitinate histone residues. Also SAGA has been shown to regulate the transcriptional activation of a subset of genes. (Adapted from FBrf0228923, FBrf0219841 and FBrf0233349).

Notes on Group

SAGA has 3 subunits in common with the ATAC complex (Gcn5, Ada3, Sgf29).

Sf3b3 and Sf3b5 are spliceosomal components of the U2 small nuclear ribonucleoprotein particle (snRNP) and have been also identified as subunits of the Drosophila SAGA (FBrf0233349). Note that in human one U2 snRNP spliceosomal subunit was identified in a SAGA-like complex (PMID:11564863).

Source Material
The SAGA COMPLEX Gene Group has been compiled by FlyBase curators using the following publication(s): Stegeman et al., 2016, Spedale et al., 2012, Weake et al., 2011, Rodriguez-Navarro, 2009, and Weake et al., 2008 .
Key Gene Ontology (GO) terms
Cellular Component
Related Gene Groups
Protein Complex group(s)
Members (21)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
enhancer of yellow 2
ENY2, late boundary complex, LBC
Splicing factor 3b subunit 3
Splicing factor 3b subunit 5
TBP-associated factor 9
dTAFII40, e(y)1, dTAFII42, TFIID, TAFII40
TBP-associated factor 12
TBP-associated factor 30kD subunit α, Taf30α, dTAFII30α, TFIID, dTAFII30
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
SAGA
SAGA complex
SPT-ADA-GCN5 ACETYLTRANSFERASE
SAGA COMPLEX
Secondary FlyBase ID(s)
References (6)