FB2025_01 , released February 20, 2025
Gene Group: JMJC FAMILY HISTONE DEMETHYLASES
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General Information
Name
JMJC FAMILY HISTONE DEMETHYLASES
Species
D. melanogaster
Symbol
JMJC-KDM
FlyBase ID
FBgg0000308
Date last reviewed
2023-02-21
Number of members
10
Description
Description
The Jumonji C (JmjC) domain-containing demethlyases catalyze histone lysine or arginine demethylation through an oxidative reaction that requires iron Fe(II) and α-ketoglutarate as cofactors. (Adapted from FBrf0195283).
Notes on Group

Not all JmjC domain-containing proteins are histone demethylases (FBrf0195283) and therefore Jarid2, JMJD4, JMJD7 and HSPBAP1 have not been included in this group.

Source Material
The JMJC FAMILY HISTONE DEMETHYLASES Gene Group has been compiled using the following publication(s): Shalaby et al., 2017, Holowatyj et al., 2015, Greer and Shi, 2012, and Klose et al., 2006 .
Key Gene Ontology (GO) terms
Molecular Function
histone demethylase activity
2-oxoglutarate-dependent dioxygenase activity
Biological Process
post-translational protein modification
Cellular Component
nucleus
Enzymatic activity
Enzyme name (EC)
1.14.11.-
Related Gene Groups
Parent group(s)
2-OXOGLUTARATE-DEPENDENT DIOXYGENASES
HISTONE DEMETHYLASES
Members (10)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
CG10600
(FlyBase, 2017-)
JMJD5
Jumonji domain containing 5
(Shalaby et al., 2017, Holowatyj et al., 2015, Klose et al., 2006)
JMJD6
Jumonji domain containing 6
PSR, dPSR, phosphatidylserine receptor
(Shalaby et al., 2017, Holowatyj et al., 2015, Klose et al., 2006)
Kdm2
Lysine demethylase 2
dKDM2, JHDM1, Lysine (K)-specific demethylase 2
(Shalaby et al., 2017, Holowatyj et al., 2015, Klose et al., 2006)
Kdm3
Lysine demethylase 3
JHDM2
(Shalaby et al., 2017, Holowatyj et al., 2015, Klose et al., 2006)
Kdm4A
Lysine demethylase 4A
dKDM4A, Histone demethylase 4A
(Shalaby et al., 2017, Holowatyj et al., 2015, Greer and Shi, 2012, Klose et al., 2006)
Kdm4B
Lysine demethylase 4B
Histone demethylase 4B
(Shalaby et al., 2017, Holowatyj et al., 2015, Greer and Shi, 2012, Klose et al., 2006)
Kdm5
Lysine demethylase 5
lid, little imaginal discs, l(2)10424, dKDM5/LID
(Shalaby et al., 2017, Holowatyj et al., 2015, Greer and Shi, 2012, Klose et al., 2006)
NO66
Nucleolar protein 66
anon-4Bd
(Shalaby et al., 2017, Holowatyj et al., 2015, Klose et al., 2006)
Utx
Utx histone demethylase
dUTX, anon-31BCa
(Shalaby et al., 2017, Holowatyj et al., 2015, Klose et al., 2006)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
JMJC-KDM
Jumonji C-domain-containing histone demethylases
JHDM
JUMONJI C DOMAIN-CONTAINING LYSINE DEMETHYLASES
JMJC FAMILY HISTONE DEMETHYLASES
Secondary FlyBase ID(s)
References (6)