FB2025_01 , released February 20, 2025
Complex: TRR COMPLEX
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General Information
Name
TRR COMPLEX
Species
D. melanogaster
Symbol
TRR
FlyBase ID
FBgg0000315
Date last reviewed
2023-08-08
Number of members
10
Description
Description
The Trithorax-related (Trr) complex is a COMPASS-like complex that mediates the methylation of histone H3K4 and demethylation of histone H3K27. (Adapted from FBrf0216343 and FBrf0218498).
Notes on Group
Source Material
The TRR COMPLEX Gene Group has been compiled using the following publication(s): Piunti and Shilatifard, 2016, Herz et al., 2012, Shilatifard, 2012, Mohan et al., 2011, and Schuettengruber et al., 2011 .
Key Gene Ontology (GO) terms
Molecular Function
histone H3K4 methyltransferase activity
histone H3K27me2/H3K27me3 demethylase activity
Biological Process
chromatin remodeling
Cellular Component
MLL3/4 complex
Enzymatic activity
Enzyme name (EC)
[histone H3]-trimethyl-L-lysine(27) demethylase (1.14.11.68)
Related Gene Groups
Parent group(s)
COMPASS-TYPE COMPLEXES
Members (10)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
ash2
absent, small, or homeotic discs 2
ash-2
(Piunti and Shilatifard, 2016, Herz et al., 2012, Shilatifard, 2012, Mohan et al., 2011, Schuettengruber et al., 2011)
Dpy-30L1
Dpy-30-like 1
Dpy30
(Piunti and Shilatifard, 2016, Herz et al., 2012, Shilatifard, 2012, Mohan et al., 2011, Schuettengruber et al., 2011)
Lpt
Lost PHDs of trr
cmi, cara mitad
(Herz et al., 2012, Mohan et al., 2011)
Ncoa6
Nuclear receptor coactivator 6
(Piunti and Shilatifard, 2016, Herz et al., 2012, Shilatifard, 2012, Mohan et al., 2011, Schuettengruber et al., 2011)
Pa1
PTIP associated 1
anon-10Ba
(Piunti and Shilatifard, 2016, Herz et al., 2012, Shilatifard, 2012, Mohan et al., 2011, Schuettengruber et al., 2011)
Ptip
PAX transcription activation domain interacting protein
(Piunti and Shilatifard, 2016, Herz et al., 2012, Shilatifard, 2012, Mohan et al., 2011, Schuettengruber et al., 2011)
Rbbp5
Retinoblastoma binding protein 5
dRbbp5
(Piunti and Shilatifard, 2016, Herz et al., 2012, Shilatifard, 2012, Mohan et al., 2011, Schuettengruber et al., 2011)
trr
trithorax-related
EG:63B12.3
(Piunti and Shilatifard, 2016, Herz et al., 2012, Shilatifard, 2012, Mohan et al., 2011, Schuettengruber et al., 2011)
Utx
Utx histone demethylase
dUTX, anon-31BCa
(Piunti and Shilatifard, 2016, Herz et al., 2012, Shilatifard, 2012, Mohan et al., 2011, Schuettengruber et al., 2011)
wds
will die slowly
zw8, l(1)zw8, zw-8, EG:BACR25B3.7, l(1)3Ad
(Piunti and Shilatifard, 2016, Herz et al., 2012, Shilatifard, 2012, Mohan et al., 2011, Schuettengruber et al., 2011)
External Data
Synonyms and Secondary IDs
Synonym(s)
TRR
TRR COMPLEX
Trithorax-related complex proteins associated with Set1-LIKE
Trr methylase
COMPASS-Like complex
MLL3/4 complex
MLL3/4
Secondary FlyBase ID(s)
References (6)